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Found 152 clinical trials
The Use of Mobile Health Technology and Behavioral Economics to Encourage Adherence in Adolescents

Familial hypercholesterolemia (FH) affects over one million Americans and increases the risk of cardiovascular disease (CVD) by as much as 20-fold. Although the use of statins can substantially reduce this risk, adherence to statins in adults and adolescence is poor. In adults, lower rates of adherence are associated with an …

genetic analysis
cardiovascular disease
statin
  • 0 views
  • 04 Oct, 2022
  • 1 location
Study of ARO-APOC3 in Adults With Familial Chylomicronemia Syndrome (FCS) (PALISADE)

The purpose or AROAPOC3-3001 is to evaluate the efficacy and safety of ARO-APOC3 in adult participants with familial chylomicronemia syndrome (FCS). Participants who have met all protocol eligibility criteria will be randomized to receive 4 total doses of ARO-APOC3 or matching placebo administered subcutaneously.

  • 0 views
  • 07 Oct, 2022
  • 25 locations
Genetic Testing and Motivational Counseling for FH (GENMOTIV-FH)

To date, there are highly effective lipid-lowering drugs, the combination of which makes it possible to achieve the target level of LDL-C in most patients with familial hypercholesterolemia (FH). However, the effectiveness of treatment of FH patients strongly depends on adherence to lipid-lowering therapy and to the healthy lifestyle, as …

genetic analysis
evolocumab
cholesterol level
statin
atorvastatin
  • 0 views
  • 04 Oct, 2022
  • 1 location
Left Ventricular Hypertrophy Reduction With Statins in Hypertensive Patients

Experimental studies have showed that statins reduce left ventricular hypertrophy. The main objective is to observe the reduction of left ventricular hypertrophy with statins in hypertensive patients. The hypothesis is that patients treated with statins will have a reduction of at least 10% compared with patients treated only with antihypertensive …

valsartan
left ventricular hypertrophy
  • 4 views
  • 07 Nov, 2020
  • 1 location
Pediatric Reporting of Adult-Onset Genomic Results

The Investigators will conduct a longitudinal, mixed-methods cohort study to assess primary and secondary psychosocial outcomes among 705 MyCode pediatric participants and their parents, and health behaviors of parents whose children receive an adult- or pediatric-onset genomic result. Data will be gathered via quantitative surveys using validated measures of distress, …

genetic counseling
cancer
Accepts healthy volunteers
heart disease
  • 4 views
  • 09 Mar, 2022
  • 1 location
Polygenic Risk Score to Predict Weight Loss Intervention in Children With Obesity

Children with obesity are prone to suffering from metabolic diseases, which undoubtedly increases the burden of public health. Since obesity is a multiple gene disease, a comprehensive approach using polygenic risk scores (PRS), rather than individual genetic variant, may be a more appropriate method. The aim of the study was …

  • 0 views
  • 04 Oct, 2022
  • 1 location
Long Term Effects of Weight Loss on Post-prandial Gut Hormone Responses and Meal Induced Thermogenesis

A study to examine post-prandial gut-hormone secretion, meal-induced thermogenesis, fasting plasma metabolomic/lipidomic and cardiovascular indices among surgically managed obese individuals in the long term compared to conservatively managed obese patients.

  • 4 views
  • 18 Feb, 2022
  • 1 location
The FOrMe Registry (The German Focal Segmental Glomerulosclerosis and Minimal Change Disease Registry) (FOrMe)

In a monocentric, later multicentric prospective approach the FOrMe registry (The German Focal Segmental Glomerulosclerosis and Minimal Change Disease Registry) aims to generate a longitudinal cohort of 150 pediatric cases of idiopathic nephrotic syndrome and 350 adult cases of biopsy-proven Minimal Change Disease (MCD) or Focal and Segmental Glomerular Sclerosis …

nephrotic syndrome
minimal change disease
kidney transplant
  • 10 views
  • 07 Feb, 2022
  • 1 location
Bezafibrate in Patients With Primary Biliary Cholangitis (PBC)

Up to 40% of patients with PBC have an inadequate response to standard treatment with UDCA, hence bezafibrate, a PPAR-agonist is being introduced as add-on therapy in these patients. sCD163, fibrosis markers and bile acid composition are of special interest in PBC. In this study, the investigators will investigate how …

  • 0 views
  • 04 Oct, 2022
  • 2 locations
Structural Stability of Carotid Plaque and Symptomatology

The purpose of the research is to understand structural plaque abnormalities that make a carotid plaque unstable and brake off (embolize) which would help to predict and treat individuals who are likely to suffer not only classic episodic major strokes but also cognitive impairment.

endarterectomy
stroke
atherosclerosis
  • 29 views
  • 11 Nov, 2021
  • 1 location