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Found 7 clinical trials
Adding Colchicine to Tocilizumab in Patients With Severe COVID-19 Pneumonia.

Colchicine acts upstream in the cytokines cascade by inhibiting the NLRP3 inflammasome while IL-6 receptor antagonists (tocilizumab) block the end result of the cytokines cascade. Hence, adding colchicine to tocilizumab with the aim of blocking the early and end products of the cytokines cascade, might reduce the risk of developing …

  • 0 views
  • 10 Dec, 2021
  • 1 location
Treatment of Severe COVID-19 Patients Using Secretome of Hypoxia-Mesenchymal Stem Cells in Indonesia

In this randomized controlled trial (RCT), severe cases of COVID-19 infection will be treated with secretome of hypoxia-mesenchymal stem cells. The improvement in clinical, laboratory, and radiological manifestations will be evaluated in treated patients compared with the control group.

  • 0 views
  • 03 Jun, 2021
  • 9 locations
Prospective Study for the Application of Cytosorb in Critically Ill Patients

The mortality of critically ill patients is persistently high and requires targeted therapy of pathophysiological disorders. One approach to optimize therapy is the use of the cytokine adsorber Cytosorb, which has a CE certification for the indications hyperinflammation, rhabdomyolysis and liver failure and is therefore frequently used in patients with …

  • 0 views
  • 15 Jun, 2021
  • 1 location
CLinical Efficacy of Hemoperfusion With a Cytokine Adsorber in Norepinephrine-Resistant SEptic Shock

Sepsis and septic shock are major causes of ICU admission worldwide. Despite recent advances in treatment, including targeted resuscitation and timely use of antimicrobial agents, mortality of ICU patients with septic shock remains steadily high. Especially in those requiring high dosage of vasopressors, whose 28-day mortality rate could reach 60%. …

  • 0 views
  • 08 Dec, 2021
  • 1 location
Non-invasive Nervus Vagus Stimulation in Patients With COVID-19 and ARDS

Critical ill COVID-19 patients often develop respiratory, hemodynamic and neuropsychiatric complications. An imbalance of sympatho-parasympathetic nervous system is discussed as one of the reasons. The nervus vagus is essential for controlling the sympatho-parasympathetic nervous system and the inflammatory processes. Aim of this study is to evaluate whether Nervus vagus stimulation …

SARS
FIO2
covid-19
assisted breathing
respiratory failure
  • 0 views
  • 17 Oct, 2021
  • 1 location
Safety and Efficacy of Hyperbaric Oxygen for ARDS in Patients With COVID-19

COVID-19 may cause severe pneumonitis that require ventilatory support in some patients, the ICU mortality is as high as 62%. Hospitals do not have enough ICU beds to handle the demand and to date there is no effective cure. We explore a treatment administered in a randomized clinical trial that …

SARS
d-dimer
FIO2
acute respiratory distress syndrome
pulmonary disease
  • 146 views
  • 18 Nov, 2021
  • 6 locations
Immune Modulation by Exosomes in COVID-19

Following whole blood stimulation with mesenchymal stem cell derived exosomes, immune phenotype, cytokine release and mRNA expression patterns from critically ill patients with COVID-19 will be determined.

Accepts healthy volunteers
  • 0 views
  • 21 Jan, 2022
  • 1 location