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Found 122 clinical trials
Lokelma for RAAS Maximisation in CKD & Heart Failure. (LIFT)

Background: CKD in patients with heart failure (HF) is common and associated with poor prognosis. Despite evidence of benefit with Renin-Angiotensin-Aldosterone-System inhibitor (RAASi) agents, they are avoided due to fear of hyperkalaemia. New potassium binders, e.g. Sodium Zirconium Cyclosilicate (SZC), reduce incidence of hyperkalaemia in CKD-HF patients and hence may …

aldosterone
heart failure
  • 0 views
  • 14 Mar, 2022
ABM/P-15 Bone Graft vs Traditional Bone Graft in Adult Spinal Deformity Surgery

The purpose of this prospective trial is to investigate ABM/P-15 bone graft versus traditional bone graft in patients undergoing surgery for Adult Spinal Deformity (ASD) in order to provide better clinical results through faster bone healing, no additional surgeries, fewer complications and thereby increase health-related quality of life. Main hypotheses: …

  • 0 views
  • 22 Mar, 2022
A Study to Evaluate the Pharmacokinetic Interaction and Safety Between BR1018-1 and BR1018-2 in Healthy Adult Subjects

The purpose of this study is to evaluate the pharmacokinetic characteristics and compare the safety and tolerability after repeated separate or combined administrations of BR1018-1 and BR1018-2 in healthy adults.

Accepts healthy volunteers
electrocardiogram
body mass index
  • 0 views
  • 04 Oct, 2022
  • 1 location
Russian Familial Hypercholesterolemia Registry (RuFH)

Cardiology Research and Production Center, including patient demographics, past medical history, family history of hypercholesterolemia, physical findings, current lipid-lowering therapies, blood tests

atherosclerosis
pcsk9
cholesterol level
low density lipoprotein
genetic analysis
  • 11 views
  • 24 Jan, 2022
  • 1 location
EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

Familial hypercholesterolaemia (FH) is a common genetic disorder resulting in marked elevations in low-density lipoprotein cholesterol (LDL-C). If untreated, lifelong exposure to elevated LDL-C

Accepts healthy volunteers
genetic disorder
premature
low density lipoprotein
cardiovascular disease
  • 76 views
  • 27 Feb, 2022
  • 1 location
HoFH, the International Clinical Collaborators - A Global HoFH Data-sharing Platform (HICC)

Homozygous familial hypercholesterolemia (HoFH), a rare inherited disorder caused by bi-allelic mutations in the LDL Receptor pathway, is characterized by extremely elevated levels of low

  • 0 views
  • 13 Oct, 2022
  • 4 locations
The Rogosin Institute Homozygous Familial Hypercholesterolemia Repository

with homozygous familial hypercholesterolemia (hoFH). Patients with this very rare disorder have very high blood levels of cholesterol from birth due to the inheritance of an abnormal gene from each

  • 16 views
  • 15 Oct, 2022
  • 1 location
Subclinical Atherosclerosis in Patients With Familial Hypercholesterolemia Treated With Evolocumab®

changes in lipid profile, oxidation markers and subclinical atherosclerosis in patients with familial hypercholesterolemia (FH) during 12 weeks of treatment with a PCSK-9 inhibitor, Evolocumab.

atherosclerosis
cholesterol level
evolocumab
  • 0 views
  • 01 Mar, 2022
  • 1 location
Effect of Breastfeeding on Lipid Profile and Cardiovascular Risk Markers in Women With Familial Hypercholesterolemia (FH-FEMINA) (FH-FEMINA)

The study aims to investigate the effects of breastfeeding on lipid profile and cardiovascular risk markers in women with familial hypercholesterolemia (FH). Women with FH who are pregnant or

statin
  • 0 views
  • 24 Oct, 2022
  • 1 location
LOWER: Lomitapide Observational Worldwide Evaluation Registry

This global product exposure registry is a multicentre, long-term, prospective, observational cohort study (exposure registry), designed to evaluate the long term safety and effectiveness of lomitapide.

  • 0 views
  • 27 Jan, 2021
  • 47 locations