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Found 137 clinical trials
Moderately Carbohydrate-restricted Diet to Treat NAFLD in Adolescents

This will be a 6-month randomized clinical trial with two arms: moderately carbohydrate-restricted diet and a fat-restricted control diet. This 6-month study will have 2 phases: a 12-week controlled feeding phase and a 12-week "free living" phase. During the controlled feeding phase, all food will be provided to the families …

hemoglobin a1c
sugars
a 12
fatty liver
insulin
  • 0 views
  • 26 May, 2022
  • 1 location
A Single-center, Randomized, Open-label, Controlled, Dose-escalating, Parallel-group Study to Assess the Anti-platelet Effect of Berberine in Patients Receiving Aspirin and Clopidogrel After Percutaneous Coronary Intervention (APLABE-PCI)

The APLABE-PCI is a single-center, randomized, open-label, controlled, dose-escalating, parallel-group study, which is designed to assess the anti-platelet effect of berberine in approximately 64 patients receiving aspirin and clopidogrel who are at > 8 but ≤ 40 weeks after percutaneous coronary intervention.

percutaneous coronary intervention
clopidogrel
plato
thrombosis
myocardial infarction
  • 23 views
  • 23 Oct, 2022
  • 1 location
Effect of PCSK9 Inhibition on Cardiovascular Risk in Treated HIV Infection (EPIC-HIV Study) (EPIC-HIV)

Atherosclerosis in the setting of HIV infection is distinct and includes increased vascular inflammation, worsened endothelial function, and a predominance of non-calcified plaque. These outcomes can be assessed using specialized noninvasive imaging which strongly predict future CV events in the general population. PCSK9 has emerged as an important pharmacologic target …

hmg-coa reductase inhibitors
hepatitis
peripheral artery disease
cholesterol level
glycosylated hemoglobin
  • 17 views
  • 09 May, 2022
  • 1 location
Lokelma for RAAS Maximisation in CKD & Heart Failure. (LIFT)

Background: CKD in patients with heart failure (HF) is common and associated with poor prognosis. Despite evidence of benefit with Renin-Angiotensin-Aldosterone-System inhibitor (RAASi) agents, they are avoided due to fear of hyperkalaemia. New potassium binders, e.g. Sodium Zirconium Cyclosilicate (SZC), reduce incidence of hyperkalaemia in CKD-HF patients and hence may …

aldosterone
heart failure
  • 0 views
  • 14 Mar, 2022
ABM/P-15 Bone Graft vs Traditional Bone Graft in Adult Spinal Deformity Surgery

The purpose of this prospective trial is to investigate ABM/P-15 bone graft versus traditional bone graft in patients undergoing surgery for Adult Spinal Deformity (ASD) in order to provide better clinical results through faster bone healing, no additional surgeries, fewer complications and thereby increase health-related quality of life. Main hypotheses: …

  • 0 views
  • 22 Mar, 2022
A High-PRotein Mediterranean Diet and Resistance Exercise for Cardiac Rehabilitation: a Pilot Randomised Controlled Trial (PRiMER)

Cardiovascular disease is responsible for a quarter of all deaths in the UK and risk seems to be higher in cardiac rehabilitation (CR) with lower body weight which may be due to sarcopenci obesity (SO) or low muscle mass with high fat mass. The investigators aim to investigate the effect …

cardiac rehabilitation
  • 0 views
  • 04 Oct, 2022
  • 1 location
A Study to Evaluate the Pharmacokinetic Interaction and Safety Between BR1018-1 and BR1018-2 in Healthy Adult Subjects

The purpose of this study is to evaluate the pharmacokinetic characteristics and compare the safety and tolerability after repeated separate or combined administrations of BR1018-1 and BR1018-2 in healthy adults.

Accepts healthy volunteers
body mass index
electrocardiogram
  • 0 views
  • 04 Oct, 2022
  • 1 location
Russian Familial Hypercholesterolemia Registry (RuFH)

Cardiology Research and Production Center, including patient demographics, past medical history, family history of hypercholesterolemia, physical findings, current lipid-lowering therapies, blood tests

atherosclerosis
low density lipoprotein
cholesterol level
pcsk9
genetic analysis
  • 11 views
  • 24 Jan, 2022
  • 1 location
EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

Familial hypercholesterolaemia (FH) is a common genetic disorder resulting in marked elevations in low-density lipoprotein cholesterol (LDL-C). If untreated, lifelong exposure to elevated LDL-C

early identification
lipoprotein cholesterol
cholesterol level
cardiovascular disease
premature
  • 76 views
  • 27 Feb, 2022
  • 1 location
HoFH, the International Clinical Collaborators - A Global HoFH Data-sharing Platform (HICC)

Homozygous familial hypercholesterolemia (HoFH), a rare inherited disorder caused by bi-allelic mutations in the LDL Receptor pathway, is characterized by extremely elevated levels of low

  • 0 views
  • 13 Oct, 2022
  • 4 locations