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Found 19 clinical trials
Pomalidomide Ixazomib and Dexamethasone With or Without Intensification by Cyclophosphamide in Relapsed or Refractory Multiple Myeloma

The study is designed as a multicenter, non-randomized, Phase II trial with one treatment arm. A total of 82 patients of both genders and older than 18 years with relapsed/refractory multiple myeloma are planned to be included in the study. After the first 6 patients will have finished the first …

alkylating agents
dexamethasone
platelet count
neutrophil count
cyclophosphamide
  • 2 views
  • 18 Sep, 2021
  • 18 locations
A Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma

The purpose of this study is to evaluate the efficacy of talquetamab in participants with relapsed or refractory multiple myeloma at the recommended Phase 2 dose(s) (RP2Ds) (Part 3).

measurable disease
multiple myeloma
  • 0 views
  • 29 Jun, 2022
  • 61 locations
A Study of Subcutaneous Daratumumab Regimens in Combination With Bispecific T Cell Redirection Antibodies for the Treatment of Participants With Multiple Myeloma

The purpose of this study is to identify recommended Phase 2 doses (RP2Ds) for each treatment combination (between daratumumab plus talquetamab and teclistamab plus daratumumab with or without pomalidomide) and to characterize the safety of each RP2D for selected treatment combinations.

proteasome inhibitor
human chorionic gonadotropin
immunoglobulins
measurable disease
daratumumab
  • 114 views
  • 29 May, 2022
  • 22 locations
Rapid Normalization of Vitamin D Deficiency in PICU (VITdALIZE-KIDS)

Vitamin D plays an important role in calcium balance, heart and lung health, inflammation, infection prevention, and muscle strength. Due to these roles, it has been suggested that critically ill patients with low vitamin D levels might have higher rates of death and worse long-term health. We believe that identifying …

calcium
cholecalciferol
malnutrition
vitamins
  • 51 views
  • 16 Jun, 2022
  • 10 locations
Rifampin in CYP24A1-related Hypercalcemia and Hypercalciuria (RICHH)

This study evaluates the efficacy of rifampin in the treatment of hypercalcemia and/or hypercalciuria in participants with biallelic inactivating mutations of the CYP24A1 gene. Eligible subjects

rifampin
calcium
  • 57 views
  • 10 Mar, 2022
  • 1 location
Surgery for Primary Hyperparathyroidism (pHPT) in Patients Older Than 65 Years Compared With Follow-up

General consensus and contemporary guidelines, recommend surgery for primary hyperparathyroidism (pHPT)for all patients below the age of 50, for patients with pronounced hypercalcemia and for

hypercalcemia
renal function
parathyroid
primary hyperparathyroidism
parathyroid surgery
  • 276 views
  • 12 Mar, 2022
  • 1 location
Testing the Addition of KRT-232 (AMG 232) to Usual Chemotherapy for Relapsed Multiple Myeloma

This phase I trial studies the side effects and best dose of MDM2 Inhibitor KRT-232 when given together with carfilzomib, lenalidomide, and dexamethasone in treating patient with multiple myeloma that has come back (relapsed) or has not responded to previous treatment (refractory). KRT-232 (AMG 232) may stop the growth of …

cancer
hypercalcemia
carfilzomib
growth factor
amg 232
  • 27 views
  • 16 Jun, 2022
  • 4 locations
Evaluating Impact of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Parathyroidectomy

This study will see if the use of near infrared autofluorescence (NIRAF) detection with an FDA-cleared device 'Parathyroid Eye (PTeye)' for identifying parathyroid glands (PGs) during parathyroidectomy (PTx) procedures is better than a surgeon's detection alone. It compares risk-benefits and outcomes in PTx patients where NIRAF detection with PTeye for …

parathyroid hormones
hyperparathyroidism
parathyroid surgery
parathyroidectomy
parathyroid
  • 0 views
  • 21 Mar, 2022
  • 1 location
Evaluating Impact of NIRAF Detection for Identifying Parathyroid Glands During Parathyroidectomy (NIRAF)

This study describes a single center, randomized, single-blinded clinical trial to assess the clinical benefits of the use of near infrared autofluorescence (NIRAF) detection with an FDA-cleared device 'Parathyroid Eye (PTeye)' for identifying parathyroid glands (PGs) during parathyroidectomy (PTx) procedures. It compares risk-benefits and outcomes in PTx patients where NIRAF …

parathyroid hormones
hyperparathyroidism
parathyroidectomy
parathyroid
primary hyperparathyroidism
  • 50 views
  • 19 Apr, 2022
  • 1 location
Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Parathyroidectomy

The goal of this study is to assess whether using PTeye (AiBiomed, Santa Barbara, CA) - a NIRAF detection modality - can improve patient outcomes and reduce healthcare associated costs after parathyroid surgeries. By being able to quickly and definitively locate parathyroid glands while in the operating room, the duration …

parathyroid hormones
hyperparathyroidism
parathyroid surgery
parathyroidectomy
parathyroid
  • 0 views
  • 14 Mar, 2022
  • 1 location