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Found 19 clinical trials
Relative Contributions of Predictors of Hyperandrogenism in Older vs. Young Women With PCOS (SHK001)

The objective of the study is to determine the relative contributions of four established predictors of hyperandrogenism (luteinizing hormone [LH] secretion, ovarian response to recombinant

luteinizing hormone
gonadotropin
Accepts healthy volunteers
hyperinsulinemia
testosterone level
  • 335 views
  • 09 Jul, 2022
  • 1 location
Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?

The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism (HA), androgen-receptor blockade (spironolactone) alone normalizes sleep-wake luteinizing

  • 8 views
  • 04 Oct, 2022
  • 1 location
Acute Progesterone Suppression of Wake vs. Sleep Luteinizing Hormone Pulse Frequency in Pubertal Girls With and Without Hyperandrogenism (CRM003)

The purpose of this study is two-fold. (1) We will determine if in mid- to late pubertal girls without hyperandrogenism (HA), progesterone (P4) acutely reduces waking luteinizing hormone (LH

Accepts healthy volunteers
  • 10 views
  • 26 May, 2022
  • 1 location
Hyperandrogenemia and Altered Day-night LH Pulse Patterns (CRM008)

The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism, androgen-receptor blockade (spironolactone) improves the ability of progesterone to acutely

hirsutism
luteinizing hormone
Accepts healthy volunteers
testosterone level
progesterone
  • 68 views
  • 29 May, 2022
  • 1 location
Acupuncture or Metformin for Insulin Resistance in Women With PCOS (PIAII)

hyperandrogenism, as well as health related quality of life (HRQoL) and symptoms of anxiety and depression. Although equally effective (acupuncture and metformin), the investigators hypothesize that acupuncture is

acne
transvaginal ultrasound
congenital adrenal hyperplasia
hydroxyprogesterone
acarbose
  • 717 views
  • 02 Jul, 2022
  • 2 locations
Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by Progesterone

During childhood, the levels of certain hormones: gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estrogen, and progesterone are very low. However, when puberty starts, GnRH and LH pulses begin to increase, but they initially do so at night only. It is unknown why GnRH and LH pulses increase …

estrogen
luteinizing hormone
gonadorelin
gonadotropin
Accepts healthy volunteers
  • 61 views
  • 24 May, 2022
  • 1 location
Inositol Supplementation to Treat Polycystic Ovary Syndrome: A Double Blind Dose Ranging RCT (INSUPP-PCOS) (INSUPP-PCOS)

To determine if Inositol, a dietary supplement, will improve ovarian and adrenal androgen excess in women with Polycystic Ovarian Syndrome(PCOS).

inositol
anovulation
free androgen index
polycystic ovary syndrome
testosterone level
  • 847 views
  • 23 Oct, 2022
  • 1 location
Effects of Fasting Mimicking Diet (FMD) in Women With Polycystic Ovary Syndrome (PCOS)

is characterized by hyperandrogenism and/or chronic anovulation which can manifest with a range of symptoms (e.g., hirsutism, acne, oligomenorrhea, and infertility) and is associated with increased

acne
metabolic syndrome
insulin
infertility
oligomenorrhea
  • 48 views
  • 22 Mar, 2022
Treating Inflammation in Polycystic Ovary Syndrome to Ameliorate Ovarian Dysfunction (TIN-PCOS-AOD)

Polycystic Ovary Syndrome (PCOS) is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovaries. Insulin resistance (IR) is a common feature of PCOS, and the resultant

acne
withdrawal bleeding
dehydroepiandrosterone
hyperinsulinemia
insulin
  • 516 views
  • 09 Jun, 2022
  • 1 location
MYPP-trial: Myo-inositol Supplementation to Prevent Pregnancy Complications in Women With Polycystic Ovary Syndrome. (MYPP)

resistance and hyperandrogenism. Pregnancies in women with PCOS have an increased risk of gestational diabetes mellitus, preeclampsia and preterm birth, and their offspring have an increased risk of aberrant

inositol
pcos
polycystic ovary syndrome
endocrine disorder
folic acid
  • 0 views
  • 07 Oct, 2022
  • 1 location