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Found 35 clinical trials
Letrozole in Clomiphene Resistant Infertile Women With Polycystic Ovarian Syndrome

Polycystic ovary syndrome accounts for the vast majority of anovulatory symptoms and hyperandrogenism in women. The diagnosis of Polycystic ovary syndrome has life-long implications, with

endometrial carcinoma
cardiovascular disease
metformin
letrozole
clomiphene
  • 33 views
  • 30 Apr, 2021
  • 1 location
Acute Progesterone Suppression of Wake vs. Sleep Luteinizing Hormone Pulse Frequency in Pubertal Girls With and Without Hyperandrogenism

The purpose of this study is two-fold. (1) We will determine if in mid- to late pubertal girls without hyperandrogenism (HA), progesterone (P4) acutely reduces waking luteinizing hormone (LH

  • 10 views
  • 26 Jan, 2021
  • 1 location
Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?

The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism (HA), androgen-receptor blockade (spironolactone) alone normalizes sleep-wake luteinizing

  • 8 views
  • 28 Jan, 2021
  • 1 location
Hyperandrogenemia and Altered Day-night LH Pulse Patterns

The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism, androgen-receptor blockade (spironolactone) improves the ability of progesterone to acutely

hirsutism
hyperandrogenism
luteinizing hormone
spironolactone
testosterone level
  • 58 views
  • 26 Jan, 2021
  • 1 location
Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by Progesterone

During childhood, the levels of certain hormones: gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estrogen, and progesterone are very low. However, when puberty starts, GnRH and LH pulses begin to increase, but they initially do so at night only. It is unknown why GnRH and LH pulses increase …

estrogen
luteinizing hormone
gonadorelin
testosterone level
progesterone
  • 61 views
  • 25 Jan, 2021
  • 1 location
Acupuncture or Metformin for Insulin Resistance in Women With PCOS

hyperandrogenism, as well as health related quality of life (HRQoL) and symptoms of anxiety and depression. Although equally effective (acupuncture and metformin), the investigators hypothesize that acupuncture is

hirsutism
metformin
acarbose
hydroxyprogesterone
cushing's syndrome
  • 519 views
  • 26 Jan, 2021
  • 2 locations
Treatment of Obesity With Topiramate in Patients With Polycystic Ovary Syndrome

Treatment of obesity related to Polycystic Ovary Syndrome with topiramate or placebo to assess improvement of clinical and laboratory parameters after 6 months of follow-up

dyslipidemia
topiramate
type 2 diabetes mellitus
diabetes
polycystic ovary syndrome
  • 124 views
  • 24 Jan, 2021
  • 1 location
Ovarian Contribution to Androgen Production in Adolescent Girls

Women with polycystic ovary syndrome (PCOS) can have unwanted facial or male-patterned body hair, irregular menstrual periods, or no menstrual periods excess body weight, and infertility. It also results in elevated androgen levels such as testosterone. In women with PCOS, the majority of excess androgens are produced by the ovaries. …

dexamethasone
luteinizing hormone
testosterone level
polycystic ovary syndrome
testosterone
  • 37 views
  • 27 Jan, 2021
  • 1 location
Inositol Supplementation to Treat PCOS (INSUPP-PCOS)

To determine if Inositol, a dietary supplement, will improve ovarian and adrenal androgen excess in women with Polycystic Ovarian Syndrome(PCOS).

anovulatory
hyperandrogenism
oligomenorrhea
testosterone level
polycystic ovary syndrome
  • 339 views
  • 30 Jul, 2021
  • 1 location
Relative Contributions of Predictors of Hyperandrogenism in Older vs. Young Women With PCOS

The objective of the study is to determine the relative contributions of four established predictors of hyperandrogenism (luteinizing hormone [LH] secretion, ovarian response to recombinant

hyperinsulinemia
hyperandrogenism
oligomenorrhea
luteinizing hormone
gonadotropin
  • 335 views
  • 03 May, 2021
  • 1 location