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Found 22 clinical trials
Letrozole in Clomiphene Resistant Infertile Women With Polycystic Ovarian Syndrome

Polycystic ovary syndrome accounts for the vast majority of anovulatory symptoms and hyperandrogenism in women. The diagnosis of Polycystic ovary syndrome has life-long implications, with

metformin
clomiphene
polycystic ovary syndrome
letrozole
cardiovascular disease
  • 271 views
  • 26 May, 2022
  • 1 location
Relative Contributions of Predictors of Hyperandrogenism in Older vs. Young Women With PCOS (SHK001)

The objective of the study is to determine the relative contributions of four established predictors of hyperandrogenism (luteinizing hormone [LH] secretion, ovarian response to recombinant

Accepts healthy volunteers
gonadotropin
luteinizing hormone
testosterone
hyperinsulinemia
  • 335 views
  • 09 Jul, 2022
  • 1 location
Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?

The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism (HA), androgen-receptor blockade (spironolactone) alone normalizes sleep-wake luteinizing

  • 8 views
  • 04 Oct, 2022
  • 1 location
Acute Progesterone Suppression of Wake vs. Sleep Luteinizing Hormone Pulse Frequency in Pubertal Girls With and Without Hyperandrogenism (CRM003)

The purpose of this study is two-fold. (1) We will determine if in mid- to late pubertal girls without hyperandrogenism (HA), progesterone (P4) acutely reduces waking luteinizing hormone (LH

Accepts healthy volunteers
  • 10 views
  • 26 May, 2022
  • 1 location
Hyperandrogenemia and Altered Day-night LH Pulse Patterns (CRM008)

The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism, androgen-receptor blockade (spironolactone) improves the ability of progesterone to acutely

Accepts healthy volunteers
spironolactone
luteinizing hormone
androgens
testosterone
  • 68 views
  • 29 May, 2022
  • 1 location
Acupuncture or Metformin for Insulin Resistance in Women With PCOS (PIAII)

hyperandrogenism, as well as health related quality of life (HRQoL) and symptoms of anxiety and depression. Although equally effective (acupuncture and metformin), the investigators hypothesize that acupuncture is

type 2 diabetes mellitus
Accepts healthy volunteers
transvaginal ultrasound
diabetes
insulin
  • 717 views
  • 02 Jul, 2022
  • 2 locations
Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by Progesterone

During childhood, the levels of certain hormones: gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estrogen, and progesterone are very low. However, when puberty starts, GnRH and LH pulses begin to increase, but they initially do so at night only. It is unknown why GnRH and LH pulses increase …

estrogen
Accepts healthy volunteers
follicle stimulating hormone
gonadotropin
luteinizing hormone
  • 61 views
  • 24 May, 2022
  • 1 location
Inositol Supplementation to Treat Polycystic Ovary Syndrome: A Double Blind Dose Ranging RCT (INSUPP-PCOS) (INSUPP-PCOS)

To determine if Inositol, a dietary supplement, will improve ovarian and adrenal androgen excess in women with Polycystic Ovarian Syndrome(PCOS).

anovulatory
androgens
testosterone
inositol
anovulation
  • 847 views
  • 23 Oct, 2022
  • 1 location
Effects of Fasting Mimicking Diet (FMD) in Women With Polycystic Ovary Syndrome (PCOS)

is characterized by hyperandrogenism and/or chronic anovulation which can manifest with a range of symptoms (e.g., hirsutism, acne, oligomenorrhea, and infertility) and is associated with increased

type 2 diabetes mellitus
Accepts healthy volunteers
diabetes
anovulatory
insulin
  • 48 views
  • 22 Mar, 2022
Treating Inflammation in Polycystic Ovary Syndrome to Ameliorate Ovarian Dysfunction (TIN-PCOS-AOD)

Polycystic Ovary Syndrome (PCOS) is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovaries. Insulin resistance (IR) is a common feature of PCOS, and the resultant

withdrawal bleeding
Accepts healthy volunteers
gonadotropin
androstenedione
insulin
  • 516 views
  • 09 Jun, 2022
  • 1 location