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Found 76 clinical trials
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Effect of Ultra-low Dose Naloxone on Remifentanil-Induced Hyperalgesia

The purpose of this study is to evaluate whether using ultra-low dose naloxone, an opioid antagonist, has the potential to block remifentanil-induced hyperalgesia and tolerance following surgery

remifentanil
opioid
spinal fusions
opioid antagonist
  • 8 views
  • 25 Nov, 2021
  • 1 location
None
The Effect of Remifentanil on Established Capsaicin-Induced Hyperalgesia in Human Volunteers

the nervous system that make the skin more sensitive at and near the injury; this is termed hyperalgesia and occurs through long term depotentiation (LTP), i.e., a change in the synaptic

chronic pain
opioid
midazolam
capsaicin
body mass index
  • 0 views
  • 07 Nov, 2020
None
The Effect of Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers

the nervous system that make the skin more sensitive at and near the injury; this is termed hyperalgesia and occurs through long term depotentiation (LTP), i.e., a change in the synaptic

chronic pain
opioid
midazolam
body mass index
remifentanil
  • 0 views
  • 07 Nov, 2020
None
The Effect of High-dose Remifentanil on Established Capsaicin-induced Hyperalgesia in Human Volunteers

the nervous system that make the skin more sensitive at and near the injury; this is termed hyperalgesia and occurs through long term depotentiation (LTP), i.e., a change in the synaptic

chronic pain
opioid
midazolam
capsaicin
body mass index
  • 0 views
  • 07 Nov, 2020
None
Effects of Pregabalin on Mechanical Hyperalgesia

The aim of this randomized placebo-controlled study is to evaluate the effects of analgetics for neuropathic pain on mechanical hyperalgesia as a kind of evoked pain. Therefore the number

polyneuropathy
pregabalin
hyperalgesia
  • 14 views
  • 07 Nov, 2020
  • 17 locations
None
Intraoperative S-ketamine to Prevent Postoperative Hyperalgesia in Patients Undergoing Video-assisted Thoracic Surgery

Postoperative hyperalgesia (POH) is a paradoxical clinical state of increased sensation of pain or increased sensitivity to non-painful stimuli at the site of surgery or at a surrounding area

  • 0 views
  • 08 Oct, 2021
None
Efficacy of Spinal Oxytocin in Healthy Volunteers

The purpose of this study is to determine the effect of intrathecal oxytocin on areas and intensity of hyperalgesia and allodynia induced by topical capsaicin.

Accepts healthy volunteers
  • 69 views
  • 02 Dec, 2021
  • 1 location
None
Cannabinoids for Taxane Induced Peripheral Neuropathy

receive the full benefit of chemotherapy as a result. Rodent studies have shown that the cannabinoids may significantly improve hyperalgesia and allodynia induced by paclitaxel. The goal of this study is

paclitaxel
cancer
breast cancer
peripheral neuropathy
docetaxel
  • 0 views
  • 15 Aug, 2021
None
POSTOPERATIVE OPIOID-SPARING EFFECT OF INTRAOPERATIVE PAIN MONITORING USING THE ANALGESIA NOCICEPTIVE INDEX (ANI) DURING IDIOPATHIC SCOLIOSIS CORRECTION IN CHILDREN.

opioid agents. This has been hypothesized to cause postoperative hyperalgesia related to both intraoperative pain (in case of under dosage) or to opioid agents (in case of over dosage). The main

  • 0 views
  • 10 Oct, 2021
None
Study to Evaluate the Efficacy of a Polyamine-deficient Diet for Treating Postoperative Pain After Abdominal Surgery

The aim of this study is to evaluate if a polyamine deficient diet started 7 days prior to a major abdominal surgery (eventration cure and digestive continuity) and followed 7 days post-surgery reduces the area under the curve of the numerical pain rating scale in the 72 hours post-surgery.

  • 2 views
  • 04 Feb, 2021
  • 7 locations