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Found 61 clinical trials
Efficacy of Spinal Oxytocin in Healthy Volunteers

The purpose of this study is to determine the effect of intrathecal oxytocin on areas and intensity of hyperalgesia and allodynia induced by topical capsaicin.

Accepts healthy volunteers
  • 143 views
  • 02 Dec, 2021
  • 1 location
ACD440 Gel in Peripheral Neuropathic Pain

This is a double-blind, randomized, placebo-controlled crossover outpatient study in patients with peripheral neuropathic pain with allodynia or hyperalgesia to cold, heat, brush and/ or

  • 0 views
  • 08 Jul, 2022
  • 1 location
A Comparative Study Between Analgesic Effect of Opioid Free and Opioid Based Anesthesia in Radical Nephrectomy Surgery

hyperalgesia. Epidurals have been associated with hypotension, post dural puncture headaches, changes in management of anticoagulation Opioid free anesthesia (OFA) is a technique in which no intraoperative

Accepts healthy volunteers
  • 0 views
  • 30 May, 2022
  • 1 location
Opioid Free Anesthesia in Total Hip Arthroplasty (OFATHA)

analgesia in THA remains controversial. Opioid free anesthesia could limit the episodes of hyperalgesia as well as tolerance and addiction to opioids. The hypothesis of this study is that an opioid

  • 3 views
  • 26 Mar, 2022
  • 1 location
POSTOPERATIVE OPIOID-SPARING EFFECT OF INTRAOPERATIVE PAIN MONITORING USING THE ANALGESIA NOCICEPTIVE INDEX (ANI) DURING IDIOPATHIC SCOLIOSIS CORRECTION IN CHILDREN.

opioid agents. This has been hypothesized to cause postoperative hyperalgesia related to both intraoperative pain (in case of under dosage) or to opioid agents (in case of over dosage). The main

  • 0 views
  • 10 Oct, 2021
Study to Evaluate the Efficacy of a Polyamine-deficient Diet for Treating Postoperative Pain After Abdominal Surgery (POLYAMAL)

The aim of this study is to evaluate if a polyamine deficient diet started 7 days prior to a major abdominal surgery (eventration cure and digestive continuity) and followed 7 days post-surgery reduces the area under the curve of the numerical pain rating scale in the 72 hours post-surgery.

  • 2 views
  • 28 Feb, 2022
  • 3 locations
Persistent Pain Induced by Uniportal Video-assisted Thoracic Surgery

The investigators investigate the prevalence of PTPS in patients receiving with uniportal video-assisted thoracic surgery (VATS), and early identify neuropathic pain as well as treated with neural protective strategy to target intercostal nerve.

  • 0 views
  • 03 Jun, 2022
  • 1 location
Evaluation of a Patient-Centred, Multidisciplinary Opioid Tapering Program for Individuals With Chronic Non-Cancer Pain on Long Term Opioid Therapy

Chronic pain management is complex, with healthcare providers historically relying on prescribing opioid medications such as morphine. Although opioids may partially improve pain, there are risks associated with them as well, including pain worsening, side effects, addiction and overdose. It is now understood that the management of chronic pain is …

chronic pain management
morphine
cancer
opioid
cancer pain
  • 6 views
  • 27 May, 2022
  • 3 locations
Comparison of Postoperative Nociception Between NOL-guided and Standard Intraoperative Analgesia Based on Fentanyl (NOLFentanyl)

sensitization expresses as hyperalgesia and allodynia, which increase postoperative pain and morbidity, but also induce permanent modifications in the nociceptive system. These effects may be ameliorated by

chronic pain
body mass index
abdominal operation
hyperalgesia
postoperative pain
  • 6 views
  • 05 Feb, 2022
  • 1 location
Effect of High-dose Naloxone Following Third Molar Extraction (TME)

. In the present study, the investigators hypothesize that a high-dose target-controlled naloxone infusion (total dose: 3.25 mg/kg) can reinstate pain and hyperalgesia 6-8 weeks after a unilateral

Accepts healthy volunteers
chronic pain
ketobemidone
codeine
oxycodone
  • 38 views
  • 25 Mar, 2022
  • 1 location