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Found 19 clinical trials
The Effect of Selective Adrenal Artery Embolization and Spironolactone on Ventricular Remodeling in Nondominant Lateral Secretory Primary Aldosteronism: A Randomized Controlled Clinical Study

The study aims to assess the effect of superselective adrenal arterial embolization on ventricular remodeling in primary aldosteronism without lateralized aldosterone secretion by comparing it with spironolactone therapy.

  • 0 views
  • 11 Oct, 2022
  • 1 location
A Study of CIN-107 in Adults With Primary Aldosteronism

This is a multicenter, open-label study in adult patients with PA to evaluate the effectiveness and safety of CIN-107 after up to 12 weeks of treatment, at doses from 2 to 8 mg per day, for the management of blood pressure in patients with primary aldosteronism (PA).

  • 2 views
  • 07 Oct, 2022
  • 2 locations
Calcium Channel Blockade in Primary Aldosteronism

Primary aldosteronism is a common cause of hypertension. Recent evidence suggests that many patients with bilateral idiopathic hyperaldosteronism harbor gain-of-function somatic mutations in

calcium channel
hypertension
renin
amlodipine
hyperaldosteronism
  • 0 views
  • 16 Dec, 2021
  • 1 location
Effects of Adrenal Artery Ablation and Spironolactone in Patients With Primary Aldosteronism

partial removal of adrenals can reduce aldosterone level, lower blood pressure and restore potassium metabolism balance. In patients with primary hyperaldosteronism, the level of aldosterone

chemical ablation
hypertension
heart failure
potassium
bilateral adrenal hyperplasia
  • 0 views
  • 24 Jan, 2021
  • 1 location
MR Antagonist and LSD1

Lysine specific demethylase-1 (LSD1) is an epigenetic regulator of gene transcription involved in the pathophysiology of elevated blood pressure and likely renal damage in Blacks. This project investigates whether a genetically driven anti-hypertensive approach proves superior in controlling blood pressure and mitigating renal injury in Blacks who carry the risk …

hypertension
amlodipine
antihypertensive drugs
eplerenone
raised blood pressure
  • 0 views
  • 04 Oct, 2022
  • 1 location
Application of 68Ga-Pentixafor PET/CT in Primary Aldosteronism and Pre-postoperative of SAAE

Primary aldosteronism is the most common cause of secondary hypertension. The two main types of primary aldosteronism are aldosteronoma(30%) and adrenal hyperplasia(60%). The gold standard that determines the diagnosis and treatment strategy of primary aldosteronism is adrenal vein sampling(AVS), but the success rate is only about 80%. Using CXCR4 as …

  • 0 views
  • 04 Oct, 2022
  • 1 location
Renal Nerve Stimulation in Uncontrolled Hypertensive Patients Undergoing Renal Denervation (RND)

Study design: Investigator initiated, single center The study is aimed To investigate the blood pressure (BP) change to renal nerve stimulation(RNS), and subsequently perform a renal denervation(RDN) procedure to verify the cutoff value (RNS-induced systolic BP change <20 mmHg in post-RDN patients) could be a useful clinical endpoint in RDN …

hypertension
  • 0 views
  • 27 Jun, 2022
  • 1 location
Primary Aldosteronism in Western Norway

In this study the investigators aim to identify and include consecutively patients with primary aldosteronism (PA) diagnosed in the Western and Mid-parts of Norway, to describe the characteristics of these patients, to explore the cardiac effects of PA before and after specific treatment, and to identify long-term outcomes after treatment. …

Accepts healthy volunteers
  • 5 views
  • 11 May, 2022
  • 1 location
Establishment of Aldosterone and Renin Reference Range (ARR)

Elevated aldosterone levels were also shown to contribute to the excess morbidity and mortality. Literature shows aldosterone and renin levels differ between ethnicity and gender. There is no established reference intervals for these two hormone levels in Asian community. We aim to establish reference intervals for plasma aldosterone and direct …

Accepts healthy volunteers
  • 0 views
  • 24 Mar, 2022
  • 1 location
Chongqing Primary Aldosteronism Study

We intends to conduct a series of original clinical research about PA, and establish a large cohort of PA and essential hypertension patients with long-term follow-up of cardiovascular events, renal end points etc. We will establish a large sample of blood, urine, adrenal tissue of the subjects, and the genomics,metabonomics, …

hyperaldosteronism
hypertension
  • 0 views
  • 25 Feb, 2022
  • 1 location