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Found 52 clinical trials
HLA Haploidentical Bone Marrow Transplant in Patients With Severe Sickle Cell Disease

multicentric interventional biomedical research phase II, prospective, non-randomized evaluating a haploidentical marrow transplants after reduced-intensity conditioning and prevention of GvHD based on cyclophosphamide administration post transplantation in patients with severe sickle cell disease.

bone marrow transplant
blood transfusion
cyclophosphamide
acute chest syndrome
chest syndrome
  • 0 views
  • 24 Jan, 2021
  • 4 locations
Frontline Oral Arsenic Trioxide for APL

The investigators have formulated an oral preparation of As2O3 (oral-As2O3), and shown that it is efficacious for APL in R1, inducing CR2 in more than 90% of patients [8,9]. Furthermore, in an effort to prevent relapse, the investigators have moved oral-As2O3 forward to the maintenance of CR1. This strategy results …

  • 0 views
  • 27 Jan, 2021
  • 1 location
An mHealth Strategy to Improve Medication Adherence in Adolescents With Sickle Cell Disease

The primary objective of this study is to evaluate a potential behavioral intervention (MED-Go app). To meet this objective, the researchers will conduct a pilot randomized controlled trial to test the feasibility and acceptability of MED-Go app in adolescents and young adults (AYA) with sickle cell disease (SCD). The long-term …

  • 0 views
  • 24 Feb, 2021
  • 1 location
The BENeFiTS Trial in Beta Thalassemia Intermedia

Beta-thalassemias and hemoglobinopathies are serious inherited blood diseases caused by abnormal or deficiency of beta A chains of hemoglobin, the protein in red blood cells which delivers oxygen throughout the body.The diseases are characterized by hemolytic anemia, organ damage, and early mortality without treatment. Increases in another type of (normal) …

  • 0 views
  • 27 Mar, 2021
  • 4 locations
KISS Study: Kinase Inhibition With Sprycel Start up

Chronic myeloid leukaemia (CML) is due to a chromosomal abnormality in white blood cells which results in abnormal multiplication. CML in its earlier, slower growing chronic phase (CP) is well controlled by the tyrosine kinase inhibitor (TKI) drug imatinib, which targets the consequences of the chromosomal abnormality, inducing a response …

basophils
imatinib
tyrosine
chronic phase chronic myeloid leukemia
kinase inhibitor
  • 636 views
  • 20 Mar, 2021
  • 9 locations
Inhaled Mometasone to Promote Reduction in Vasoocclusive Events 2

The study team proposes a triple-blind, placebo-controlled, phase II clinical trial of once-daily inhaled mometasone for 48 weeks (with 4-week washout at study completion) in individuals with Sickle Cell Disease (SCD) who report episodic cough or wheeze (ECW) but do not have asthma. Patients will be recruited from and followed …

cough
hydroxyurea
asthma
hemoglobin s
  • 0 views
  • 27 Jan, 2021
  • 2 locations
GPS Compared With BAT in AML CR2/CR2p

To assess the safety and efficacy of galinpepimut-S compared with investigator's choice of best available therapy (BAT) on overall survival (OS) in subjects with acute myeloid leukemia (AML) who are in second complete remission 2 (CR2)/second complete remission with incomplete platelet recovery (CR2p).

blast cells
cancer
refractory acute myeloid leukemia (aml)
venetoclax
gilbert's syndrome
  • 1 views
  • 24 Jan, 2021
  • 2 locations
Tyrosine Kinase Inhibition to Treat Myeloid Hypereosinophilic Syndrome

The purpose of this study is to evaluate the safety and efficacy of the tyrosine kinase inhibitor, imatinib mesylate (Gleevec ) in reducing peripheral blood eosinophilia in patients with the myeloid form of hypereosinophilic syndrome (HES). Patients with the hypereosinophilic syndrome who meet a set of criteria designed to select …

  • 4 views
  • 20 Apr, 2021
  • 1 location
Safety Tolerability Pharmacokinetics and Pharmacodynamics of Escalating Multiple Oral Doses of AG-348 in Subjects With Stable Sickle Cell Disease

Background Sickle Cell Disease (SCD) is an inherited blood disorder. People with SCD have abnormal hemoglobin in their red blood cells. Researchers are investigating the safety and efficacy of an investigational medicine called AG-348 (mitapivat sulfate) to determine if it will help people with SCD. Objective To test the tolerability …

blood transfusion
abnormal hemoglobin
blood disorder
absolute neutrophil count
electrophoresis
  • 17 views
  • 09 May, 2021
  • 1 location
Blinatumomab and Tyrosine Kinase Inhibitor Therapy in People With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

: The purpose of this study is to test whether blinatumomab in combination with TKI therapy (such as dasatinib) is an effective treatment for people with Ph+ ALL. Researchers want to improve the response to standard-of-care treatment of corticosteroids + TKI therapy by adding the study drug, blinatumomab.

flow cytometry
lymphoid leukemia
tyrosine
kinase inhibitor
blinatumomab
  • 2 views
  • 15 Mar, 2021
  • 2 locations