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Found 52 clinical trials
Ropeginterferon Alfa-2b (P1101) vs. Anagrelide in Essential Thrombocythemia Patients With Hydroxyurea Resistance or Intolerance

This is a Phase 3 open-label, multicenter, randomized, active-controlled study designed to compare the efficacy and safety and tolerability of P1101 compared with ANA after 12 months of treatment as second-line therapy for subjects with ET who have had a suboptimal or failed response to HU.

platelet count
thrombocytosis
ropeginterferon alfa-2b
interferon
hydroxyurea
  • 0 views
  • 20 Mar, 2021
  • 51 locations
Hydroxyurea Therapy for Neurological and Cognitive Protection in Pediatric Sickle Cell Anemia in Uganda ( BRAINSAFE-II )

that hydroxyurea therapy will prevent, stabilize or improve SCV and its effects. The study is an open label, single arm clinical trial to test the impact of hydroxyurea treatment in 270

  • 0 views
  • 06 Apr, 2021
  • 1 location
Allograft for Sickle Cell Disease and Thalassemia

The design of the study incorporates the following features: This is a phase II study to determine the safety and therapeutic potential of a new transplant approach (disease-free survival, graft versus myeloma effect) and to evaluate its toxicity profile (immediate toxicity, graft-versus-host disease, graft rejection, mortality) in a patient population …

  • 28 views
  • 18 Feb, 2021
  • 1 location
Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia

RATIONALE: Monoclonal antibodies such as gemtuzumab ozogamicin can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. It is not yet known whether gemtuzumab ozogamicin is more effective than standard supportive care in treating older patients who have acute myeloid leukemia. PURPOSE: …

monoclonal antibodies
gemtuzumab ozogamicin
myeloid leukemia
monoclonal antibody therapy
cancer
  • 30 views
  • 07 Nov, 2020
  • 2 locations
Treatment Modification Based on Early Assessment of CML Patients

The investigators will check the feasibility of using early molecular response for making treatment decisions. Patients diagnosed with chronic myeloid leukemia will commence imatinib treatment. After 3 months of treatment their response will be assessed. If molecular response would be less the 10% (BCR-ABL1/ABL ISI >10%)imatinib therapy will be stopped …

philadelphia chromosome positive chronic myelogenous leukemia
leukemia
kinase inhibitor
nilotinib
tyrosine
  • 5 views
  • 08 Nov, 2020
  • 1 location
Hydroxyurea Versus Aspirin and Hydroxyurea in Essential Thrombocythemia

ratio of aspirin maintenance in high risk Essential thrombocythemia (ET) patients, in hematological response (modified by amendment 1/03/2017) on Hydroxyurea.

essential thrombocythemia
thrombocytosis
thrombosis
aspirin
hydroxyurea
  • 1 views
  • 21 Jan, 2021
An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions

The purpose of this Phase 3 study is to evaluate the efficacy and safety of Luspatercept compared with placebo in subjects with myeloproliferative neoplasm (MPN)-associated Myelofibrosis (MF) and anemia on concomitant Janus kinase 2 (JAK2) inhibitor therapy and who require red blood cell count (RBC) transfusions. The study is divided …

anemia
bilateral oophorectomy
cancer
vasectomy
  • 0 views
  • 22 Jun, 2021
  • 158 locations
A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis Post Polycythemia Vera Myelofibrosis or Post-Essential Thrombocythemia Myelofibrosis

This study (study ID PAC203 North America; PAC303 ex-North America) is evaluating 200 mg BID of pacritinib compared to physician's choice (P/C) therapy in patients with MF and severe thrombocytopenia (platelet count <50,000/L). Approximately 348 patients in total will be enrolled, randomized 2:1 to either pacritinib (approximately 232 patients) or …

pacritinib
platelet count
thrombocythemia
left upper quadrant pain
conjugated bilirubin
  • 506 views
  • 15 Jun, 2021
  • 176 locations
Hydroxyurea Optimization Through Precision Study

Hydroxyurea Optimization through Precision Study (HOPS) is a prospective, multi-center, randomized trial that will directly compare a novel, individualized dosing strategy of hydroxyurea to

sickle hemoglobin
hemoglobin f
anemia
thalassemia
hydroxyurea
  • 82 views
  • 07 Apr, 2021
  • 14 locations
Pharmacokinetics of Oral Hydroxyurea Solution

An open label, safety and pharmacokinetic study of oral hydroxyurea solution administered to children from 6 months to 17.99 years (i.e. to the day before 18th birthday), with a 12 15 month

anemia
hydroxyurea
  • 7 views
  • 10 Mar, 2021
  • 6 locations