Found 51 clinical trials
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Multi-country trial
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Phase 3 trial
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Accepting Seniors
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Accepting adults
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100s of participants
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An interventional trial
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For all genders
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Currently Recruiting
Ropeginterferon Alfa-2b (P1101) vs. Anagrelide in Essential Thrombocythemia Patients With Hydroxyurea Resistance or Intolerance
This is a Phase 3 open-label, multicenter, randomized, active-controlled study designed to compare the efficacy and safety and tolerability of P1101 compared with ANA after 12 months of treatment as second-line therapy for subjects with ET who have had a suboptimal or failed response to HU.
- 0 views
- 20 Mar, 2021
- 51 locations
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Phase 3 trial
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Accepting pediatric ages
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Accepting adults
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100s of participants
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An interventional trial
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For all genders
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Currently Recruiting
Hydroxyurea Therapy for Neurological and Cognitive Protection in Pediatric Sickle Cell Anemia in Uganda ( BRAINSAFE-II )
that hydroxyurea therapy will prevent, stabilize or improve SCV and its effects. The study is an open label, single arm clinical trial to test the impact of hydroxyurea treatment in 270
- 0 views
- 06 Apr, 2021
- 1 location
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Phase 2 trial
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Accepting adults
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10s of participants
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An interventional trial
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For all genders
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Currently Recruiting
Allograft for Sickle Cell Disease and Thalassemia
The design of the study incorporates the following features: This is a phase II study to determine the safety and therapeutic potential of a new transplant approach (disease-free survival, graft versus myeloma effect) and to evaluate its toxicity profile (immediate toxicity, graft-versus-host disease, graft rejection, mortality) in a patient population …
- 28 views
- 18 Feb, 2021
- 1 location
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Multi-country trial
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Phase 2 trial
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Accepting Seniors
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Accepting adults
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100s of participants
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An interventional trial
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For all genders
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Oncology
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Currently Recruiting
Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia
RATIONALE: Monoclonal antibodies such as gemtuzumab ozogamicin can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. It is not yet known whether gemtuzumab ozogamicin is more effective than standard supportive care in treating older patients who have acute myeloid leukemia. PURPOSE: …
- 30 views
- 07 Nov, 2020
- 2 locations
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Phase 2 trial
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Accepting pediatric ages
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Accepting Seniors
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100s of participants
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An interventional trial
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For all genders
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Oncology
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Currently Recruiting
Treatment Modification Based on Early Assessment of CML Patients
The investigators will check the feasibility of using early molecular response for making treatment decisions. Patients diagnosed with chronic myeloid leukemia will commence imatinib treatment. After 3 months of treatment their response will be assessed. If molecular response would be less the 10% (BCR-ABL1/ABL ISI >10%)imatinib therapy will be stopped …
- 5 views
- 08 Nov, 2020
- 1 location
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Phase 3 trial
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Accepting Seniors
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Accepting adults
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1000s of participants
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An interventional trial
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For all genders
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Currently Recruiting
Hydroxyurea Versus Aspirin and Hydroxyurea in Essential Thrombocythemia
ratio of aspirin maintenance in high risk Essential thrombocythemia (ET) patients, in hematological response (modified by amendment 1/03/2017) on Hydroxyurea.
- 1 views
- 21 Jan, 2021
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Multi-country trial
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Phase 3 trial
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Accepting Seniors
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Accepting adults
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100s of participants
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An interventional trial
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For all genders
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Hematology
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Currently Recruiting
A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis Post Polycythemia Vera Myelofibrosis or Post-Essential Thrombocythemia Myelofibrosis
This study (study ID PAC203 North America; PAC303 ex-North America) is evaluating 200 mg BID of pacritinib compared to physician's choice (P/C) therapy in patients with MF and severe thrombocytopenia (platelet count <50,000/L). Approximately 348 patients in total will be enrolled, randomized 2:1 to either pacritinib (approximately 232 patients) or …
- 506 views
- 10 Apr, 2021
- 176 locations
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Accepting pediatric ages
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Accepting adults
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100s of participants
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An interventional trial
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For all genders
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Family Medicine
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Currently Recruiting
Shared-Decision Making for Hydroxyurea
The goal of the study is to understand how best to help parents of young children with sickle cell disease and their clinicians have a shared discussion about hydroxyurea (one that takes into
- 59 views
- 27 Jan, 2021
- 8 locations
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Phase 3 trial
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Accepting pediatric ages
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Accepting adults
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100s of participants
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An interventional trial
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For all genders
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Family Medicine
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Currently Recruiting
Hydroxyurea Optimization Through Precision Study
Hydroxyurea Optimization through Precision Study (HOPS) is a prospective, multi-center, randomized trial that will directly compare a novel, individualized dosing strategy of hydroxyurea to
- 82 views
- 07 Apr, 2021
- 14 locations
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Multi-country trial
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Phase 2 trial
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Accepting pediatric ages
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Accepting adults
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10s of participants
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An interventional trial
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For all genders
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Family Medicine
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Currently Recruiting
Pharmacokinetics of Oral Hydroxyurea Solution
An open label, safety and pharmacokinetic study of oral hydroxyurea solution administered to children from 6 months to 17.99 years (i.e. to the day before 18th birthday), with a 12 15 month
- 7 views
- 10 Mar, 2021
- 6 locations