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Found 93 clinical trials
A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration

This phase I/II trial is designed to study the side effects, best dose and efficacy of adding hydroxychloroquine to dabrafenib and/or trametinib in children with low grade or high grade brain

  • 4 views
  • 29 May, 2022
  • 9 locations
Combination of Trametinib (MEK Inhibitor) and Hydroxychloroquine (HCQ) (Autophagy Inhibitor) in Patients With KRAS Mutation Refractory Bile Tract Carcinoma (BTC).

combination of trametinib and hydroxychloroquine (HCQ) increases the period of time it takes for a person s bile tract carcinoma (BTC) to get worse. Eligibility Adults

cancer
EGFR
measurable disease
hydroxychloroquine
KRAS
  • 0 views
  • 16 Jun, 2022
  • 1 location
LY3214996 +/- HCQ in Pancreatic Cancer

This study is evaluating the safety and efficacy of combining the study drug LY3214996 with hydroxychloroquine sulfate (HCQ) in patients with advanced pancreatic cancer.

cancer chemotherapy
platelet count
carcinoma
antineoplastic
adenocarcinoma
  • 0 views
  • 22 Apr, 2022
  • 1 location
Study of Combination Therapy With the MEK Inhibitor Cobimetinib Immune Checkpoint Blockade Atezolizumab and the AUTOphagy Inhibitor Hydroxychloroquine in KRAS-mutated Advanced Malignancies

, cobimetinib, and hydroxychloroquine is safe, and if it will decrease the size of the tumor and prolong life in patients whose tumors contain this mutation. Cobimetinib and atezolizumab are both approved by

absolute neutrophil count
platelet count
capecitabine
KRAS
fluorouracil
  • 0 views
  • 02 Nov, 2021
  • 1 location
COAST Therapy in Advanced Solid Tumors and Prostate Cancer (COAST)

The purpose of this Phase I/II study is to determine the safety and effectiveness of up to 5 study drugs used together for the treatment of solid tumor cancers. The drugs are hydroxychloroquine

  • 0 views
  • 22 Apr, 2022
  • 1 location
Study of Anti-Malarials in Incomplete Lupus Erythematosus

hydroxychloroquine can slow accumulation of disease features. Effects on clinical progression of symptoms, patient-reported outcomes and changes in the immune markers of response will be measured and toxicity of the

antinuclear antibody
antimalarials
arthritis
hydroxychloroquine
lupus
  • 118 views
  • 09 Nov, 2021
  • 7 locations
Immunosuppressant Regimens for Living Fetuses Study

evaluate the effect of hydroxychloroquine with or without prednisone combined with anticoagulation on pregnancy outcomes in recurrent pregnancy loss patients with UCTD.

heparin
immunosuppressant
connective tissue diseases
aspirin
  • 11 views
  • 15 Feb, 2022
  • 1 location
Immune-Mediated Pathophysiology And Clinical Triage Program

known if this is the best or safest treatment. Hydroxychloroquine is a medication that is often used to treat inflammatory joint pain, such as rheumatoid arthritis, has relatively few side

drug test
renal function
cancer
stiffness
total bilirubin
  • 0 views
  • 28 Oct, 2021
  • 1 location
Management of Cardiovascular Disease in Kidney Disease (MaCK) Study (MaCK)

related deaths in CKD. This study assesses a novel therapy (hydroxychloroquine, HCQ) for the treatment of CVD in patients with CKD. This is the first human proof-of-concept study and is planned to be

nephropathy
diabetes
albumin/creatinine ratio
MRI
chronic disease
  • 3 views
  • 07 Apr, 2022
  • 1 location
Povidone Iodine Nasal Irrigation and Gargling to Reduce Viral Load in Asymptomatic Patients With COVID-19 (SMART-CORE)

The emergence of a novel coronavirus(SARS-CoV-2) in late 2019 has resulted in a global epidemic of the infectious condition COVID-19. Since March 2022, the Omicron mutant has caused widespread transmission in Shanghai, China, and is characterized by the majority of asymptomatic patients. Although showing no obvious symptoms, the asymptomatic patients …

  • 0 views
  • 03 Jun, 2022
  • 1 location