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Found 90 clinical trials
Hydroxychloroquine Abemaciclib and Endocrine Therapy in Hormone Receptor Positive (HR+)/Her 2 Negative Breast Cancer

The hypothesis is that abemaciclib synergizes with autophagy inhibitor hydroxychloroquine (HCQ/ Plaquenil), inducing apoptosis leading to tumor regression.

  • 0 views
  • 03 Nov, 2021
  • 1 location
Hydroxychloroquine and Chlorphenesin Carbamate in Combination With mFOLFIRINOX in Pancreatic Cancer

targeting unbalanced gene) developed by Oncocross, Chlorphenesin carbamate, and Hydroxychloroquine were discovered as candidate drugs having anti-metastatic effects. This study aimed to evaluate the

cancer chemotherapy
metastatic pancreatic cancer
folfirinox
metastasis
  • 0 views
  • 24 Mar, 2022
  • 1 location
ABemacicliB or Abemaciclib and HydroxYchloroquine to Target Minimal Residual Disease in Breast Cancer

This is a Phase II randomized, controlled, open label breast cancer clinical trial. 66 patients will be enrolled. The drugs being studied are hydroxychloroquine (Plaquenil) and abemaciclib (also

erbb2
progesterone
tamoxifen
adjuvant chemotherapy
progesterone receptor
  • 0 views
  • 22 Dec, 2021
  • 1 location
Binimetinib and Hydroxychloroquine in Patients With Advanced KRAS Mutant Non-Small Cell Lung Cancer

This study will evaluate using hydroxychloroquine (HCQ) along with binimetinib as an effective method for treating cancer. All patients will receive binimetinib at a standard dose approved for

Accepts healthy volunteers
KRAS
systemic therapy
lung carcinoma
  • 0 views
  • 06 Apr, 2022
  • 1 location
Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer

This clinical trial will assess the safety and early efficacy of Hydroxychloroquine or Avelumab, with or without Palbociclib, in early-stage ER+ breast cancer patients who are found to harbor

erbb2
tamoxifen
bisphosphonate
mammogram
palbociclib
  • 0 views
  • 10 Aug, 2021
  • 1 location
Phase I/II Study of Hydroxychloroquine With Itraconazole With Biochemically Recurrent Prostate Cancer (HITMAN-PC)

Recent pre-clinical work has suggested that Itraconazole has an anti-cancer effect that works synergistically with hydroxychloroquine. This may delay the need for androgen deprivation therapy

recurrent prostate cancer
prostatectomy
androgen suppression
androgens
serum testosterone
  • 15 views
  • 09 May, 2022
  • 1 location
Paricalcitol and Hydroxychloroquine in Combination With Gemcitabine and Nab-Paclitaxel for the Treatment of Advanced or Metastatic Pancreatic Cancer

This phase II trial investigates how well paricalcitol and hydroxychloroquine work when combined with gemcitabine and nab-paclitaxel in treating patients with pancreatic cancer that has spread

aptt
neutrophil count
thromboplastin
MRI
metastatic adenocarcinoma
  • 0 views
  • 05 Mar, 2021
  • 3 locations
A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration

This phase I/II trial is designed to study the side effects, best dose and efficacy of adding hydroxychloroquine to dabrafenib and/or trametinib in children with low grade or high grade brain

  • 4 views
  • 29 May, 2022
  • 9 locations
Combination of Trametinib (MEK Inhibitor) and Hydroxychloroquine (HCQ) (Autophagy Inhibitor) in Patients With KRAS Mutation Refractory Bile Tract Carcinoma (BTC).

combination of trametinib and hydroxychloroquine (HCQ) increases the period of time it takes for a person s bile tract carcinoma (BTC) to get worse. Eligibility Adults

KRAS
hydroxychloroquine
EGFR
measurable disease
cancer
  • 0 views
  • 01 Jul, 2022
  • 1 location
LY3214996 +/- HCQ in Pancreatic Cancer

This study is evaluating the safety and efficacy of combining the study drug LY3214996 with hydroxychloroquine sulfate (HCQ) in patients with advanced pancreatic cancer.

neutrophil count
metastatic pancreatic cancer
adenocarcinoma
carcinoma
ct scan
  • 0 views
  • 22 Apr, 2022
  • 1 location