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Found 89 clinical trials
Hydroxychloroquine in Individuals At-risk for Type 1 Diabetes Mellitus (TN-22)

The study is a 2-arm, double blinded, multicenter, 2:1 randomized, placebo controlled clinical trial. Subjects will receive hydroxychloroquine or placebo and close monitoring for progression of

  • 13 Feb, 2022
  • 51 locations
Hydroxychloroquine and Indapamide in SPMS

The purpose of this clinical trial is to determine if HCQ in a dose of 400mg daily and indapamide in a dose of 2.5mg daily can help in reducing the progression of disability in people with secondary progressive multiple sclerosis. The number of participants in this study will be 35. …

  • 25 May, 2022
  • 1 location
Hydroxychloroquine and Cognitive Function After Surgery

The purpose of this study is to determine whether hydroxychloroquine decreases the relative leakage of the brain barrier after surgery.

  • 22 Mar, 2022
  • 1 location
Hydroxychloroquine (HCQ) for Recurrent Pregnancy Loss

treatment to improve the chance of a live birth. Exciting indications for using Hydroxychloroquine (HCQ) include: Malaria profylaxis and treatment, systemic and discoid lupus erythematosus (SLE) and

discoid lupus erythematosus
  • 01 Mar, 2022
  • 1 location
Oral Hydroxychloroquine (HCQ) for Retinitis Pigmentosa Caused by P23H- Rhodopsin (RHO)

This research study is being done to learn what effect 12 months of treatment with oral hydroxychloroquine (HCQ) will have on the retina in people with retinitis pigmentosa (RP). The hypothesis

corrected visual acuity
pupil dilation
genetic analysis
retinal degeneration
  • 21 Mar, 2022
  • 1 location
Study of Hydroxychloroquine in Patients With X-linked Alport Syndrome in China (CHXLAS)

This Phase 2 randomized controlled trial will study the safety, tolerability, and efficacy of Hydroxychloroquine in qualified patients with Alport syndrome. The trial will be open-label

  • 24 Sep, 2021
  • 1 location
CLEVER Pilot Trial: A Phase II Pilot Trial of HydroxyChLoroquine, EVErolimus or the Combination for Prevention of Recurrent Breast Cancer

To evaluate the feasibility of administering HCQ, EVE or the combination in patients who have completed primary therapy for breast cancer and harbor bone marrow disseminated tumor cells.

tumor cells
triple-negative breast cancer
invasive breast cancer
primary tumor
  • 14 Jun, 2022
  • 1 location
To Evaluate Maximally Tolerated Dose (MTD), Safety and Efficacy of CPI-613® (Devimistat) Plus Hydroxychloroquine in Patients With Relapsed or Refractory Clear Cell Sarcoma of Soft Tissue

The goal of this trial in Phase I is to determine the maximally tolerated dose (MTD) of hydroxychloroquine in combination with devimistat in patients with relapsed or refractory Clear Cell

  • 26 Jul, 2022
  • 8 locations
PHL Treatment in Pancreatic Cancer

This proposal will investigate the effect of paricalcitol, hydroxychloroquine, and losartan (PHL) combination of 3 stroma-modifying drugs on pancreatic adenocarcinoma and its stroma.

  • 25 Jul, 2022
  • 1 location
Hydroxychloroquin (HCQ) in chILD of Genetic Defect

The purpose of this proposed research is to investigate the efficacy and safety of hydroxychloroquine sulfate (HCQ, Quensyl) for pediatric ILD(chILD) caused by pulmonary surfactant-associated

  • 27 Feb, 2022
  • 1 location