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Found 31 clinical trials
Non-Steroidal or Opioid Analgesia Use for Children With Musculoskeletal Injuries (No OUCH)

children with acute MSK limb injuries. The pain medicines the investigators are studying are ibuprofen (Advil/Motrin), acetaminophen (Tylenol/Tempra), and hydromorphone (Dilaudid). This study will

  • 8 views
  • 08 Jun, 2022
  • 13 locations
Evaluating Buprenorphine/Naloxone Microdosing vs. Standard Dosing in Emergency Departments

This is a multi-centre, open-label RCT at four Emergency Departments (EDs) in British Columbia and Alberta. The purpose of the current study is to compare the effectiveness of buprenorphine/naloxone microdosing and standard dosing take-home induction regimens at enabling patients to successfully complete the induction regimen, and at retaining patients on …

  • 14 views
  • 10 Aug, 2021
  • 4 locations
Epidural Versus Paravertebral Block Analgesia After Hepatectomy

The best mode of analgesia delivery after hepatectomy is currently unknown. Many institutions routinely use continuous epidural analgesia (CEA) for pain control in this patient population. A functioning CEA provides adequate analgesia, but is associated with high failure rates (20-30%) and sometimes significant hemodynamic disturbances (hypotension) requiring an increased amount …

  • 1 views
  • 05 May, 2022
  • 1 location
Improving Tissue Oxygenation in Breast Reconstruction Surgery

Breast reconstruction is an integral part of breast cancer care. There are two main types of breast reconstruction: alloplastic (using implants), and autologous (using patient's tissue). The latter creates a more natural breast mound, and avoids long-term concerns requiring surgical re-intervention associated with implant-based surgery. The deep inferior epigastric perforator …

  • 10 views
  • 21 Apr, 2022
  • 2 locations
Hydromorphone for ICU-analgesia in Patients With Non-mechanical Ventilation

Hydromorphone has a clear analgesic effect, and has few advantages in respiratory depression and gastrointestinal motility. The study will further explore the continuous pumping-dose of

hydromorphone
  • 0 views
  • 23 Mar, 2022
  • 1 location
Hydromorphone vs Fentanyl in Children Undergoing Tonsillectomy Surgery

A RCT to compare hydromorphone versus fentanyl for pain control following tonsillectomy or adenotonsillectomy surgery.

hydromorphone
analgesia
tonsillectomy
adenoidectomy
Accepts healthy volunteers
  • 3 views
  • 11 Mar, 2022
  • 1 location
Spinal Hydromorphone Versus Morphine for Post-Cesarean Delivery Analgesia

. Hydromorphone, another drug from the same class, might be used alternatively, but we need to prove that it is not inferior to morphine.

bupivacaine
hydromorphone
analgesia
pain relief
pain relieving
  • 0 views
  • 11 Jun, 2021
  • 1 location
Effect of Opioid Infusion Rate on Abuse Liability Potential of Intravenous Hydromorphone for Cancer Pain

phase IV trial will determine the AL potential of a slow IV hydromorphone (SH) bolus administration compared with a fast IV hydromorphone (FH) bolus administration among inpatients with cancer pain. It

hydromorphone
opioid
analgesics
cancer
cancer pain
  • 0 views
  • 24 Mar, 2022
  • 1 location
Pediatric Pain Optimization After Tonsillectomy

The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery.

adenoidectomy
Accepts healthy volunteers
  • 0 views
  • 02 May, 2022
  • 1 location
A Study to Evaluate the Abuse Potential of Oxymorphone Compared to Other Mu Opioid Agonists.

other mu opioid analgesics. The present study is designed to examine the abuse liability of intravenous oxymorphone compared to other mu opioid agonists (oxycodone, morphine, and hydromorphone) among

morphine
opioid use disorder
drug abuse
opioid
urine drug screen
  • 100 views
  • 12 Feb, 2022