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Found 18 clinical trials
A Study of Non-Steroidal or Opioid Analgesia Use for Children With Musculoskeletal Injuries: The No OUCH Trials (No OUCH)

children with acute MSK limb injuries. The pain medicines the investigators are studying are ibuprofen (Advil/Motrin), acetaminophen (Tylenol/Tempra), and hydromorphone (Dilaudid). This study will

  • 20 views
  • 28 Oct, 2022
  • 13 locations
Evaluating Buprenorphine/Naloxone Microdosing vs. Standard Dosing in Emergency Departments

This is a multi-centre, open-label RCT at four Emergency Departments (EDs) in British Columbia and Alberta. The purpose of the current study is to compare the effectiveness of buprenorphine/naloxone microdosing and standard dosing take-home induction regimens at enabling patients to successfully complete the induction regimen, and at retaining patients on …

  • 14 views
  • 10 Aug, 2021
  • 4 locations
The Effect of General Anesthesia on Pharmacokinetics of Oxycodone in Pediatric

Oxycodone is an oral opioid analgesic that is most commonly prescribed for the management of pain in post-operative patients at Boston Children's Hospital. Oxycodone has been widely used in adults and children to relieve post-operative pain. However, its pharmacokinetics (what it does in the body) and pharmacodynamics (how it works) …

  • 0 views
  • 04 Oct, 2022
  • 1 location
Improving Tissue Oxygenation in Breast Reconstruction Surgery

Breast reconstruction is an integral part of breast cancer care. There are two main types of breast reconstruction: alloplastic (using implants), and autologous (using patient's tissue). The latter creates a more natural breast mound, and avoids long-term concerns requiring surgical re-intervention associated with implant-based surgery. The deep inferior epigastric perforator …

  • 15 views
  • 21 Apr, 2022
  • 2 locations
Pediatric Pain Optimization After Tonsillectomy

The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery.

Accepts healthy volunteers
adenoidectomy
  • 0 views
  • 08 Apr, 2023
  • 1 location
Intrathecal Opioids for Colorectal Resection

This research study is being done to determine the optimal dose of spinal morphine and hydromorphone in patients undergoing minimally-invasive (i.e., surgery performed through small entry sites

  • 0 views
  • 04 Oct, 2022
  • 1 location
Opioid Reduction in Orthopaedic Surgery (OREOS) - Knees (OREOS)

. Doctors often prescribe opioid medications for pain after surgery (e.g. Percocet, hydromorphone, codeine). These medications can be helpful for some people, but they can also be dangerous, particularly

total knee replacement
codeine
joint reconstruction
opioid
knee arthritis
  • 0 views
  • 23 Apr, 2022
  • 1 location
Ketamine for Pain Control After Severe Traumatic Injury

This study evaluates if the early utilization of ketamine infusion therapy among acutely injured adult trauma hospital inpatients with an ISS >15 will decrease the amount of opioid pain medication used as compared with placebo group. Ketamine infusion therapy initiated within 12 hours of hospital arrival will lead to decreased …

pain relieving
oral morphine
ketamine
opioid
morphine
  • 28 views
  • 22 Dec, 2021
  • 1 location
Thoracic Epidural Analgesia or Four-Quadrant Transversus Abdominus Plane Block in Reducing Pain in Patients Undergoing Liver Surgery

This phase III trial studies how well thoracic epidural analgesia or four-quadrant transversus abdominus plane block works in reducing pain in patients undergoing liver surgery. It is not yet known whether thoracic epidural analgesia or four-quadrant transversus abdominus plane block may help people to recover more completely and more quickly …

liver surgery
hepatectomy
cancer
analgesia
bowel resection
  • 17 views
  • 14 Aug, 2021
  • 2 locations
A Prospective Pilot Study of a Non-Narcotic Post-Operative Course After Colectomy

With this pilot investigation, the investigators aim to challenge the reliance on opiate analgesia following colon and rectal surgery. Narcotic misuse and abuse is a pressing public health concern, and reduction in prescription rates could help to mitigate this issue. The goal of this pilot study is to establish feasibility …

pain relieving
Accepts healthy volunteers
analgesia
analgesics
  • 0 views
  • 24 Oct, 2022
  • 1 location