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Found 43 clinical trials
Hydrocortisone and Fludrocortisone for Critical Illness-related Corticosteroid Insufficiency (HORNbILL)

The study aims at assessing the efficacy and the safety of hydrocortisone combined with fludrocortisone compared to placebo in ICU adults with critical illness related corticosteroid

  • 0 views
  • 21 Mar, 2022
Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment (CareOnTIME)

This is a controlled, open study designed to compare the effects of dual-release hydrocortisone preparations versus conventional glucocorticoid therapy on clinical, anthropometric parameters

adrenal insufficiency
metabolic syndrome
prednisolone
21-ohd
deficiency
  • 56 views
  • 14 Apr, 2022
  • 1 location
HYdrocortisone and VAsopressin in Post-RESuscitation Syndrome

The primary objective is to demonstrate the superiority of arginine-vasopressin (AVP) and hydrocortisone compared with norepinephrine regarding day-30 survival and neurological recovery in post

  • 0 views
  • 23 Jun, 2021
  • 1 location
Low Dose of Hydrocortisone and Fludrocortisone in Adult Cardiogenic Shock. (COCCA)

The purpose of this randomized controlled trial is to evaluate the hemodynamic effect of low dose corticosteroid therapy (hydrocortisone and fludrocortisone) in the treatment of adult

ejection fraction
systolic blood pressure
oliguria
pulmonary congestion
congestion
  • 24 views
  • 30 Jun, 2022
  • 12 locations
Comparison of Chronocort Versus Standard Hydrocortisone Replacement Therapy in Participants Aged 16 Years and Over With Congenital Adrenal Hyperplasia (CONnECT)

This study is a randomized, double-blind, active-controlled, phase III study of Chronocort® compared with immediate-release hydrocortisone replacement therapy in participants aged 16 years and

fludrocortisone
prednisolone
deficiency
glucocorticoid therapy
replacement therapy
  • 0 views
  • 27 Jul, 2022
Imaging CRF X NOP Interactions in CUD

This study uses [11C]NOP-1A positron emission tomography (PET) and a hydrocortisone challenge to image the interaction between nociceptive opioid peptide (NOP) receptors and cortisol

Accepts healthy volunteers
  • 4 views
  • 14 Jul, 2022
  • 1 location
Acute Consequences Of Food-induced Glucocorticoid Secretion In Healthy Individuals (Gluco-Feed)

In a randomized, cross-over study, 20 healthy volunteers will receive a block and replace therapy that mimics physiological GC rhythm (metyrapone plus hydrocortisone) or placebo. Participants

Accepts healthy volunteers
  • 0 views
  • 21 Apr, 2022
  • 1 location
[C-11]NPA PET-amphetamine in Cocaine Use Disorders

This study uses [11C]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in subjects with cocaine use disorders (CUD). Amphetamine-induced dopamine release data from this study will be correlated with [11C]NOP-1A VT measured at baseline in the midbrain. [11C]NOP-1A PET data …

  • 0 views
  • 08 Jul, 2022
  • 1 location
The WWRD Study: AVM0703 for Treatment of Leukemia or Lymphoma

This is an open-label, Phase 1/2 study designed to characterize the safety, tolerability, Pharmacokinetics(PK), and preliminary antitumor activity of AVM0703 administered as a single intravenous (IV) infusion to patients with lymphoid malignancies.

  • 7 views
  • 15 Mar, 2022
  • 5 locations
Treatment of Acute Lymphoblastic Leukemia Ph '(BCR / ABL) Positive Patients Aged > 55 Years

This study proposes to provide adequate treatment and is based on current scientific evidence for elderly patients with ALL Bcr / Abl positive. To determine whether low-dose chemotherapy associated with imatinib or dasatinib has acceptable tolerability in elderly patients. To determine whether this association can increase the rate and quality …

  • 1 views
  • 28 Jun, 2022
  • 1 location