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Found 140 clinical trials
A Clinicobiological Database in Metastatic Digestive Cancers (BCB-CBIO-DIG)

Creation of a collection of blood samples that will be collected before and then under treatment in patients with digestive adenocarcinoma during the 1st and 2nd metastatic line and which, depending on scientific progress, can be used for research projects aimed at developing tailored patient management strategies.

adenocarcinoma
adenocarcinoma of the colon
cancer
gastrointestinal cancer
  • 0 views
  • 09 Feb, 2022
  • 1 location
Gedatolisib Plus Talazoparib in Advanced Triple Negative or BRCA1/2 Positive, HER2 Negative Breast Cancers

This study is designed to determine the RP2D of gedatolisib in combination with talazoparib and to evaluate the efficacy of this combination in advanced HER2 negative breast cancer that is triple negative or BRCA1/2 positive (deficient).

brain metastases
measurable disease
cancer
parp inhibitor
metastasis
  • 5 views
  • 26 Mar, 2022
  • 5 locations
The PROMISE Study: Duavee in Women With DCIS

The main purpose of this study is to determine if taking the study drug, conjugated estrogens/bazedoxifene (Duavee) causes any changes in the proliferation markers within the breast tissue of the study subjects. The study drug is approved by the US Food and Drug Administration in healthy postmenopausal women to treat …

hysterectomy
biomarker analysis
core needle biopsy
estrogen
breast cancer
  • 264 views
  • 26 Jan, 2022
  • 10 locations
Albumin-bound Paclitaxel and Carboplatin Versus Epirubicin and Docetaxel for Triple-negative Breast Cancer

To investigate the efficacy of albumin-bound paclitaxel combined with carboplatin versus epirubicin combined with docetaxel as neoadjuvant therapy for triple-negative breast cancer.

docetaxel
estrogen
epirubicin
erbb2
progesterone receptor
  • 0 views
  • 31 Jul, 2021
  • 7 locations
Imaging Versus Cardiac Biomarker Monitored HER2 Directed Therapy in Patients With Breast Cancer (HER2BIC)

Due to a risk of heart failure during HER2 directed therapy in breast cancer, treatment is monitored with imaging of myocardial function, which is resource demanding for both patients and the health care system. The purpose of this study is to evaluate, if biomarkers can replace imaging based examinations of …

  • 0 views
  • 14 Jun, 2022
  • 1 location
Vaccine Therapy in Treating Patients With Metastatic Solid Tumors

This phase I trial studies the side effects and best dose of vaccine therapy in treating patients with metastatic solid tumors. Vaccines made from antibodies and peptides combined with tumor cells may help the body build an effective immune response to kill tumor cells.

serum bilirubin
solid tumour
endocrine therapy
platelet count
metastasis
  • 37 views
  • 03 Nov, 2021
  • 1 location
Albumin-Bound Paclitaxel Combined With Antiangiogenic Agents in First-line Treatment of Relapsed or Metastatic TNBC

This is a prospective, randomized, open-label clinical study. 128 patients with relapsed or metastatic triple-negative breast cancer (TNBC) who had not been systematically treated are going to be enrolled and randomly assigned to 3 groups. Group A: albumin-bound paclitaxel (260mg/m2, intravenous infusion, once every 3 weeks). Group B: albumin-bound paclitaxel …

growth factor
measurable disease
paclitaxel
mammogram
metastasis
  • 0 views
  • 07 Apr, 2022
  • 1 location
Pembrolizumab, Endocrine Therapy, and Palbociclib in Treating Postmenopausal Patients With Newly Diagnosed Metastatic Stage IV Estrogen Receptor Positive Breast Cancer

This phase II trial studies how well pembrolizumab works when given together with endocrine therapy and palbociclib in treating postmenopausal patients with newly diagnosed stage IV estrogen receptor positive breast cancer that has spread to other parts of the body (metastatic). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help …

alopecia
thromboplastin
biomarker analysis
monoclonal antibody therapy
liver metastasis
  • 99 views
  • 13 Apr, 2022
  • 7 locations
Improving Uptake of Genetic Cancer Risk Assessment in African American Women- Video

Genetic counseling and testing (GCT) provides invaluable information for women who are at-risk of hereditary breast and/or ovarian cancer (HBOC). Black women underutilize GCT compared to White women. This study will conduct a RCT to test the efficacy of a culturally-tailored theory-based video intervention aimed to address key psychosocial factors …

  • 0 views
  • 08 Dec, 2021
  • 1 location
Nadunolimab in Combination With Gemcitabine Plus Carboplatin in Patients With Advanced Triple Negative Breast Cancer. (TRIFOUR)

Triple negative breast cancer (TNBC) represents approximately 15% of all breast cancers (BC) worldwide. The term triple negative means that tumor growth is not stimulated by the hormones estrogen and progesterone, nor by the HER2 protein, so unlike other types of BC, TNBC, which is an aggressive form of BC, …

HER2
progesterone
carboplatin
estrogen
erbb2
  • 0 views
  • 16 Mar, 2022
  • 8 locations