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Found 141 clinical trials
Neratinib and Everolimus, Palbociclib, or Trametinib in Treating Participants With Refractory and Advanced or Metastatic Solid Tumors With EGFR Mutation/Amplification, HER2 Mutation/Amplification, or HER3/4 Mutation or KRAS Mutation

This phase I trial studies the side effects and best dose of neratinib in combination with everolimus, palbociclib, or trametinib in participants with solid tumors with EGFR mutation/amplification, HER2 mutation/amplification, HER3/4 mutation, or KRAS mutation that do not respond to treatment (refractory) and have spread to other parts of the …

erbb2
tumor cells
measurable disease
KRAS
epidermal growth factor receptor
  • 36 views
  • 31 Jan, 2022
  • 1 location
Determinants of Resistance to Endocrine Therapy and a Cyclin-dependent Kinases 4 and 6 (CDK4/6) Inhibitor for HR+ MBC

The goal of this research study is to determine if the investigators can predict which participants will respond to endocrine therapy and a cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor for metastatic breast cancer and which participants will not. Investigators will use information from the tumor tissue and serial blood …

erbb2
estrogen receptor
stage iv breast cancer
aromatase inhibitor
palbociclib
  • 14 views
  • 26 Feb, 2022
  • 1 location
M7824 in Treating Patients With Stage II-III HER2 Positive Breast Cancer

This phase I trial studies how well anti-PD-L1/TGFbetaRII fusion protein M7824 (M7824) works in treating patients with stage II-III HER2 positive breast cancer. Immunotherapy with M7824 may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

erbb2
tubal ligation
targeted therapy
human epidermal growth factor
oophorectomy
  • 16 views
  • 12 Feb, 2022
  • 1 location
Screening Magnetic Resonance Imaging of the Brain in Patients With Breast Cancer

This research study is studying the usefulness of magnetic resonance imaging (MRI) to screen for brain metastases (spread of the breast cancer to the brain).

erbb2
inflammatory breast cancer
human epidermal growth factor
brain metastases
her1
  • 2 views
  • 18 Feb, 2022
  • 1 location
Pyrotinib, Dalpiciclib(SHR6390) and Endocrine Therapy in Subjects With Dual-receptor Positive(ER+/HER2+) Advanced Breast Cancer (PLEASURABLE)

This is a single-center Ib / II study of triple targeted drug combination (endocrine therapy,novel HER2-targeted small molecule inhibitor pyrotinib and CDK4/6 inhibitor dalpiciclib(SHR6390) ) as a first or second line of therapy in patients with relapsed/metastatic hormone receptor positive and HER2-positive breast cancer.

erbb2
aromatase inhibitor
advanced breast cancer
measurable disease
HER2
  • 21 views
  • 25 Mar, 2022
  • 1 location
A Pilot Study of Tomographic Optical Breast Imaging (DBT-TOBI) to Monitor Response to Neoadjuvant Therapy

This research study is evaluating whether the use of digital breast tomosynthesis and near-infrared tomographic optical breast imaging (DBT-TOBI) scans can predict the response of triple negative or HER2+ breast cancer to neoadjuvant chemotherapy. The study radiologic scan involved in this study is digital breast tomosynthesis (also called 3 Dimensional …

  • 0 views
  • 16 May, 2021
  • 1 location
Niraparib Plus Aromatase Inhibitors for Luminal-like(HER2- ER+) and gBRCA or HDR+ Metastatic Breast Cancer (LUZERN)

This study evalues the efficacy -as determined by the clinical benefit rate (CBR)- of niraparib in combination with AIs in unresectable locally advanced or metastatic HR-positive/HER2-negative breast cancer patients harboring either gBRCAms or gBRCAwt and HRD. The planned number of patients is 23. Investigational product is Niraparib 100 mg and …

her2-negative breast cancer
bisphosphonate
aromatase inhibitor
BRCA1/2
tumor cells
  • 0 views
  • 27 Jan, 2021
  • 9 locations
Genetic Analysis-Guided Irinotecan Hydrochloride Dosing of mFOLFIRINOX in Treating Patients With Locally Advanced Gastroesophageal or Stomach Cancer

This pilot clinical trial studies genetic analysis-guided irontecan hydrochloride dosing of modified fluorouracil, irinotecan hydrochloride, leucovorin calcium, oxaliplatin (mFOLFIRINOX) in treating patients with gastroesophageal or stomach cancer that has spread from where it started to nearby tissue or lymph nodes. Drugs used in chemotherapy, such as fluorouracil, irinotecan hydrochloride, leucovorin …

irinotecan
calcium
metastasis
gastric cancer
adenocarcinoma
  • 67 views
  • 23 May, 2021
  • 3 locations
Multi-4SCAR-T Therapy Targeting Breast Cancer

The purpose of this study is to assess the feasibility, safety and efficacy of multiple 4th generation CAR-T cells targeting Her2, GD2, and CD44v6 surface antigen in breast cancer. Another goal of the study is to learn more about the activities of the multi-CAR T cells and their persistency in …

erbb2
HER2
  • 0 views
  • 24 Jan, 2021
  • 1 location
The Trial Comparing Dose-dense AC-T With TP as Adjuvant Therapy for TNBC With Homologous Recombination Repair Deficiency

The purpose of this trial is to compare the 3-year disease-free survival of dose-dense epirubicin and cyclophosphamide followed by paclitaxel with paclitaxel plus carboplatin as adjuvant therapy for triple-negative breast cancer with homologous recombination repair deficiency. The other purpose of this trial is to observe the patient's tolerance.

  • 0 views
  • 22 Jan, 2021
  • 1 location