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Found 5 clinical trials
ALlogeneic Cardiosphere-derived Stem Cells (CDCs) for Pulmonary Hypertension therApy

Pulmonary Arterial Hypertension or PAH is a progressive condition for which there is no cure. Even with substantial pharmacologic advances in the modern treatment era, survival still remains unacceptably poor, as reported in large PAH registries. Preclinical studies suggest that the administration of allogeneic CDCs have the potential to reduce …

  • 97 views
  • 25 Mar, 2021
  • 1 location
A Study of Ralinepag to Evaluate Effects on Exercise Capacity by CPET in Subjects With WHO Group 1 PH

Study ROR-PH-302, ADVANCE CAPACITY, is designed to evaluate the effects of ralinepag therapy on exercise capacity as assessed by change in peak oxygen consumption (VO2) derived from cardiopulmonary exercise testing (CPET) after 28 weeks of treatment

stress test
endothelin
ralinepag
exercise stress test
endothelin receptor antagonist
  • 0 views
  • 22 Sep, 2021
  • 32 locations
A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients

Study ROR-PH-301, ADVANCE OUTCOMES, is designed to assess the efficacy and safety of ralinepag when added to pulmonary arterial hypertension (PAH) standard of care or PAH-specific background therapy in subjects with World Health Organization (WHO) Group 1 PAH.

endothelin
digoxin
endothelin receptor antagonist
diuretics
calcium channel blockers
  • 5463 views
  • 24 Sep, 2021
  • 308 locations
Tamoxifen Therapy to Treat Pulmonary Arterial Hypertension

The main purpose of this clinical trial is to examine the feasibility and effects of tamoxifen in subjects with pulmonary arterial hypertension (PAH). The study will evaluate how well the drug is tolerated, and its impact on functional condition and selected biomarkers. Changes in tricuspid annular plane systolic excursion (TAPSE) …

walk tests
tapse
hypertension
connective tissue disease
  • 58 views
  • 24 Feb, 2021
  • 1 location
Hormonal Metabolic and Signaling Interactions in PAH

Our hypothesis is that optimal treatment of the dysfunctional metabolic pathways which underlie PAH will improve pulmonary vascular function and consequences of the disease.

  • 51 views
  • 04 Jul, 2021
  • 1 location