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Found 5 clinical trials
Featured trial
Eltrombopag Added to Standard Immunosuppression in Treatment-Naive Severe Aplastic Anemia

Background: Severe aplastic anemia is a rare and serious blood disorder. It happens when the immune system starts to attack the bone marrow cells. This causes the bone marrow to stop making red blood cells, platelets, and white blood cells. Standard treatment for this disease is horse-ATG and cyclosporine, which …

anemia
anemia studies
aplastic anemia
myelodysplastic syndrome (mds)
myelodysplastic syndromes
  • 132 views
  • 22 Dec, 2020
  • 1 location
None
Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)

SSA is a combination of 3 drugs (Cyclosporine [CsA], Eltrombopag [EPAG], and horse anti-thymocyte globulin [h-ATG]). Researchers want to see if starting people at a lower dose of CsA with EPAG before

blood disorder
antithymocyte globulin
horse anti-thymocyte globulin
reticulocyte count
eltrombopag
  • 2 views
  • 08 Nov, 2021
  • 1 location
None
Eltrombopag+hATG+CsA vs. hATG+CsA in Children With Severe AA

The analysis of our own clinical data suggests that majority of the hematologic responses observed after the course of h-ATG/CsA is partial, and about 10% tend to have cyclosporine dependence. The aim of the current study is to improve the rate and the quality of hematologic response as well as …

  • 39 views
  • 21 Mar, 2021
  • 1 location
None
Methylprednisolone Horse Anti-Thymocyte Globulin Cyclosporine Filgrastim and/or Pegfilgrastim or Pegfilgrastim Biosimilar in Treating Patients With Aplastic Anemia or Low or Intermediate-Risk Myelodysplastic Syndrome

This phase II trial studies methylprednisolone, horse anti-thymocyte globulin, cyclosporine, filgrastim, and/or pegfilgrastim or pegfilgrastim biosimilar in treating patients with aplastic

white blood cell count
filgrastim
cytopenia
antithymocyte globulin
horse anti-thymocyte globulin
  • 34 views
  • 27 Jan, 2021
  • 2 locations
None
Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia

Background Severe aplastic anemia is a rare and serious blood disorder. It happens when the immune system starts to attack the bone marrow cells. This causes the bone marrow to stop making red blood cells, platelets, and white blood cells. Standard treatment for this disease is horse-ATG and cyclosporine, which …

white blood cells
blood disorder
horse anti-thymocyte globulin
reticulocyte count
eltrombopag
  • 114 views
  • 18 Jul, 2021
  • 1 location