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Found 79 clinical trials
Craniofacial Microsomia: Accelerating Understanding of the Significance and Etiology (CAUSE)

The CAUSE study is a multicenter study, with domestic (n=4) and international (n=6) study sites. Children and young adults (ages 0-18) who have microtia and/or craniofacial microsomia and their parents are invited to participate. Children and parents are asked to provide a DNA sample (blood or saliva) and are asked …

  • 05 Mar, 2022
  • 9 locations
Environmental Factors and Embryonic Development Project (EFED)

The Environmental Factors and Embryonic Development Project was set up to investigate environmental exposures and behavioral factors responsible for embryonic dysplasia and gestational complications in pregnant women.

Accepts healthy volunteers
  • 20 Feb, 2022
B-vitamin Levels and Adverse Pregnancy Outcomes

This prospective case-control study aims to examine the effects of blood vitamin B levels in first-trimester pregnant women on the pregnancy outcomes

Accepts healthy volunteers
  • 18 Oct, 2021
  • 1 location
Mayo AVC Registry and Biobank

Arrhythmogenic ventricular cardiomyopathy (AVC) is a genetic condition which affects the heart and can lead to heart failure and rhythm problems, of which, sudden cardiac arrest or death is the most tragic and dangerous. Diagnosis and screening of blood-relatives is very difficult as the disease process can be subtle, but …

heart failure
genetic condition
  • 11 May, 2022
  • 2 locations
An Investigation of Pituitary Tumors and Related Hypothalmic Disorders

There is a variety of tumors affecting the pituitary gland in childhood; some of these tumors (eg craniopharyngioma) are included among the most common central nervous system tumors in childhood. The gene(s) involved in the pathogenesis of these tumors are largely not known; their possible association with other developmental defects …

Accepts healthy volunteers
linkage analysis
central nervous system tumors
cushing's syndrome
  • 23 May, 2022
  • 1 location
Adipose Tissue and Circulating Markers of Inflammation in GH Deficiency and Changes With GH Therapy

will also obtain adipose tissue biopsies from healthy subjects matched to the growth hormone deficiency (GHD) subjects. Adipose tissue specimens will be analyzed for adipose tissue morphology

insulin tolerance
somatomedin c
  • 29 Jan, 2022
  • 1 location
Urethral Stricture After Transurethral Resection of the Prostate/Bladder: a Prospective Study of Risk Factors

There is currently no prognostic or predictive risk marker for this urethral stricture disease. The most conservative standard treatment for urethral stricture (internal urethrotomy) has a very high recurrence rate (greater than 75%) and, on many occasions, reconstructive urologists have to choose within a great variety of further complex interventions. …

  • 19 Mar, 2021
  • 1 location
Assessment of Adherence Quality of Life Clinical Response and Safety of Daily and Long-Acting Growth Hormone Therapy

children with growth hormone deficiency (GHD). These objectives will be evaluated every 6 months for subjects prior to switch from DGH to LAGH, and 6 months after.

  • 16 Oct, 2021
  • 1 location
Skeletal Muscle Effects of GH in Boys

The purpose of the study is to measure the functional effects of recombinant GH in skeletal muscle, in addition to growth promotion, in short prepubertal boys with either growth hormone

short stature
hormone deficiency
Accepts healthy volunteers
  • 06 May, 2022
  • 1 location
Will Autologous Platelet Rich Plasma Able To Restore Ovarian Function?

A-PRP (Autologous Platelet Rich Plasma) is becoming widely used in a variety of medical procedures seeking tissue remodeling and/or healing as an intervention. To date, applications in orthopedics, wound healing, dermatology and plastic surgery have gained general acceptance, primarily as the role of platelets and their activation in tissue repair …

follicle stimulating hormone
Accepts healthy volunteers
anti-mullerian hormone
  • 29 Oct, 2021
  • 1 location