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Found 131 clinical trials
Featured trial
A Phase 4, Randomized, Open-label, Multicenter Efficacy and Safety Study of Standard Dose of Radium-223 Dichloride vs. Standard Doses of Novel Anti-hormonal Therapy (NAH) in Patients With Bone Dominant Metastatic Castration Resistant Prostate Cancer (mCRPC) Progressing on/After One Line of NAH

Researchers in this study want to compare how well drug radium-223 dichloride (Xofigo) and new (novel) anti-hormonal (NAH) therapy work in participants with prostate gland cancer which has spread to the bone and progressed on or after one line of NAH therapy. Meanwhile researchers want to compare the safety of …

  • 13 views
  • 08 Feb, 2022
  • 20 locations
Featured trial
A multicenter clinical study of the Sonablate® 500 (Sonablate) for the TreAtment of locally Recurrent prostate cancer with HIFU(STAR Trial)

A multicenter clinical study of the Sonablate® 500 (Sonablate) for the TreAtment of locally Recurrent prostate cancer with HIFU(STAR Trial)

  • 229 views
  • 25 Mar, 2021
  • 1 location
Featured trial
PROSTATE CANCER RESEARCH STUDY

PROSTATE CANCER RESEARCH STUDY

  • 86 views
  • 08 Nov, 2020
  • 1 location
PreOperative Endocrine Therapy for Individualised Care With Abemaciclib (POETIC-A)

POETIC-A is a phase 3 trial which targets post-menopausal primary breast cancer patients with a high 5-year risk of relapse as determined by a high Ki67 after 2 weeks aromatase inhibitor therapy pre-surgery. Eligible patients will be randomised to standard adjuvant endocrine therapy alone or standard adjuvant endocrine therapy with …

  • 0 views
  • 25 Mar, 2022
  • 23 locations
Effect of Gender Affirming Hormone Therapy on Glucose Metabolism

The study will test: whether estrogen treatment in transwomen is associated with improved insulin sensitivity and beta cell function whether testosterone treatment in transmen is associated with worsening insulin sensitivity and beta cell function whether estrogen therapy leads to enhanced immune response in older transwormen

Accepts healthy volunteers
  • 18 views
  • 23 Mar, 2022
  • 1 location
Lu-177-PSMA-I&T for Metastatic Castration-Resistant Prostate Cancer

A Multi-Center, Open-Label, Randomized Phase 3 Trial Comparing the Safety and Efficacy of 177Lu-PSMA-I&T versus Hormone Therapy in Patients with Metastatic Castration-Resistant Prostate

  • 0 views
  • 17 Mar, 2022
  • 6 locations
Menopause Effects on Vascular Function

impact of ovarian hormones on the mechanisms that regulate vascular function in women to provide a better understanding of the cardiovascular efficacy of hormone therapy.

heart disease
Accepts healthy volunteers
estrogen
cancer
diabetes
  • 40 views
  • 24 Feb, 2022
  • 1 location
Exercise Treatment With Standard Therapy for Metastatic Breast Cancer

exercise helps delay the development of resistance to hormone therapy while slowing the growth of tumors.

  • 3 views
  • 18 Apr, 2022
  • 8 locations
Exemestane Letrozole or Anastrozole in Treating Postmenopausal Women With Clinical Stage II and III Estrogen Receptor Positive Breast Cancer

before surgery. In this research study 3 drugs called hormone therapy (a drug used to lower the level of the hormone estrogen) will be tested. The hormone therapies being tested in this study

anastrozole
letrozole
exemestane
estrogen
estrogen receptor
  • 33 views
  • 07 Nov, 2020
  • 1 location
SBRT in Early Breast Cancer in Elderly Women

-called primary endocrinotherapy. In Italy the recent AIOM guidelines of 2019 exclude, in patients with hormone-sensitive disease and age older than 70, the omission of surgery in favor of hormone

  • 0 views
  • 16 Oct, 2021
  • 1 location