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Found 90 clinical trials
Featured trial
HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma

Gene transfer is a new cancer therapy takes white blood cells from a person and grows them in a lab. The cells are changed with a virus to attack tumor cells, then returned to the person. Researchers want to see if this therapy fights kidney cancer cells. Metastatic renal cell …

clear cell renal cell carcinoma
primary cancer
carcinoma
clear cell carcinoma
renal cell cancer
  • 144 views
  • 22 Dec, 2020
  • 1 location
None
Histocompatibility Leukocyte Antigen (HLA)-A*0201 Restricted Peptide Vaccine Therapy in Patients With Non-Small Cell Lung Cancer

The purpose of this study is to evaluate the safety and time to progression of HLA-A*0201 restricted epitope peptides URLC10, VEGFR1 and VEGFR2 emulsified with Montanide ISA 51.

VEGFR2
platelet count
  • 32 views
  • 07 Nov, 2020
  • 1 location
None
Histocompatibility Leukocyte Antigen (HLA)-A*2402 Restricted Peptide Vaccine Therapy in Patients With Non-Small Cell Lung Cancer

The purpose of this study is to evaluate the safety and time to progression of HLA-A*2402 restricted epitope peptides URLC10, TTK and KOC1 emulsified with Montanide ISA 51.

platelet count
  • 15 views
  • 07 Nov, 2020
  • 1 location
None
Study of SQZ-AAC-HPV in Patients With HPV16+ Recurrent Locally Advanced or Metastatic Solid Tumors

with immune checkpoint inhibitors in HLA-A*02+ patients with recurrent, locally advanced or metastatic human papillomavirus strain 16 positive (HPV16+) solid tumors. The study includes patients with

  • 4 views
  • 08 Sep, 2021
  • 1 location
None
Study of SQZ-PBMC-HPV in Patients With HPV16+ Recurrent Locally Advanced or Metastatic Solid Tumors

with atezolizumab or other immune checkpoint inhibitors in HLA-A*02+ patients with recurrent, locally advanced or metastatic human papillomavirus strain 16 positive (HPV16+) solid tumors. The study

solid tumour
measurable disease
cancer
  • 7 views
  • 31 Jul, 2021
  • 12 locations
None
The Efficacy of Immunosuppressive Therapy Combined With Cord Blood Transfusion in Treatment of Severe Aplastic Anemia

(Thymoglobuline, Genzyme) 3.5mg/kg/d5d plus oral cyclosporine A (CSA) Cord blood transfusion group: In addition to the same dose and course of ATG and CSA , one unit of cord blood having no more than 2 HLA-A, B

paroxysmal nocturnal hemoglobinuria
immunosuppressant
immunosuppression
aplastic anemia
cyclosporine
  • 13 views
  • 17 Oct, 2021
  • 1 location
None
Intra Bone Marrow Injection Of Unrelated Cord Blood Cells

Compared to other stemcell sources cord blood (CB) is easier and safer to procure, has no donor attrition, a limitless supply, reduced viral transmission, less acute & chronic GVHD, is rich in hematopoietic progenitor cells, and immaturity of T-cell-mediated immunity. CB has delayed neutrophil and platelet engraftment, a prolonged immune …

neutrophil count
graft versus host disease
hematologic malignancy
cancer
anemia
  • 15 views
  • 07 Nov, 2020
  • 1 location
None
EBV-TCR-T Cells for EB Virus Infection After HSCT

This is a single center, single arm, open-label, phase I study to evaluate the safety and efficacy of EBV-TCR-T cells in patients with EB virus infection after HSCT.

  • 0 views
  • 24 Jan, 2021
  • 1 location
None
CMV-TCR-T Cells for CM Virus Infection After HSCT

This is a single cente, single arm, open-label, phase I study to evaluate the safety and effectiveness of CMV-TCR-T cell immunotherapy in treating CMV virus infection after HSCT.

  • 0 views
  • 17 Feb, 2021
  • 2 locations
None
Combination of Chemoradiation Therapy and Epitope Peptide Vaccine Therapy in Treating Patients With Esophageal Cancer

The purpose of this study is to evaluate the safety and immune response of multiple peptides (URLC10, TTK, KOC1 VEGFR1, and VEGFR2) emulsified with Montanide ISA51 in combination with chemotherapy (CDDP, 5-FU) plus radiation therapy in treating patients with unresectable, advanced or recurrent esophageal cancer.

vaccine therapy
esophageal cancer
recurrent esophageal cancer
measurable disease
fluorouracil
  • 11 views
  • 07 Nov, 2020
  • 1 location