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Found 40 clinical trials
Pancreatic Cancer Evolution Upon Treatment

valuable source of cancer cells, both for the histological diagnosis and as the source of tumor macromolecules, including DNA and RNA. Study design This is a prospective study enrolling patients

adenocarcinoma
fine needle biopsy
pdac
pancreatic ductal adenocarcinoma
cancer chemotherapy
  • 0 views
  • 04 Oct, 2022
  • 1 location
Early Detection of Tumors of the Digestive Tract by Confocal Endomicroscopy

epithelium in vivo and histological diagnosis during endoscopy. Among the applications already established for its use, stand out diagnosis of Barrett's esophagus, gastric atrophy and intestinal metaplasia

adenocarcinoma
neck cancer
esophageal adenocarcinoma
adenocarcinoma of esophagus
metaplasia
  • 14 views
  • 12 Feb, 2022
  • 1 location
An Italian Multicenter Phase II Trial of Metronomic Temozolomide in Unfit Patients With Advanced Neuroendocrine Neoplasms (NENs): MeTe Study (MeTe)

analysed. Eligible study population: Patients with histological diagnosis of low grade advanced NEN treated unfit for systemic treatments, for one year from the start of the accrual. Endpoints and

  • 0 views
  • 13 Oct, 2022
  • 1 location
In Vivo PARP-1 Expression With 18F-FTT PET/CT in Pancreatic Cancer

The investigators plan to enroll 30 evaluable patients with (1) a histological diagnosis of advanced pancreatic ductal adenocarcinoma who have demonstrated at least stable disease following 16

adenocarcinoma
pancreatic ductal adenocarcinoma
cancer chemotherapy
pancreatic adenocarcinoma
breast ductal carcinoma
  • 8 views
  • 02 Mar, 2022
  • 1 location
Phase 1/2 Study of MRTX1719 in Solid Tumors With MTAP Deletion

This is a Phase 1/2, open-label, multicenter, study of the safety, tolerability, PK, PD, and anti-tumor activity of MRTX1719 patients with advanced, unresectable or metastatic solid tumor malignancy with homozygous deletion of the MTAP gene.

measurable disease
  • 0 views
  • 04 Oct, 2022
  • 4 locations
Combined Active Treatment in Type 2 Diabetes With NASH (COMBATT2NASH)

The aim of this multicentre, prospective, placebo-controlled, double-blind, randomized, 3-arm parallel group, interventional study is to assess for the first time the effects of either a combined therapy with the antihyperglycemic drugs semaglutide and empagliflozin or empagliflozin monotherapy compared to placebo as potential treatments for non-alcoholic steatohepatitis (NASH) in patients …

hypoglycemic agents
semaglutide
hemoglobin a1c
  • 0 views
  • 07 Oct, 2022
  • 16 locations
Neoadjuvant Immunotherapy With Chemotherapy for Stage I-IIIB Non-Small Cell Lung Cancer Patients

A phase II, single-arm, open-label study that assesses feasibility, safety and efficacy of combined neoadjuvant chemotherapy and immunotherapy with PD-(L)1 inhibitor in stage I-IIIB NSCLC adult patients followed by adjuvant PD-(L)1 inhibitor treatment for up to 1 year

lung carcinoma
measurable disease
cancer chemotherapy
pd-1 inhibitor
  • 0 views
  • 05 Jul, 2021
  • 1 location
PROTECT: On-line Adaptive Proton Therapy for Cervical Cancer (PROTECT)

This prospective, multicenter, nonrandomized phase-II-trial investigates in clinical practice the differences between intensity modulated proton therapy (IMPT) and standard intensity-modulated radiation therapy (IMRT) or volumetric-modulated arc therapy (VMAT) in the effects on dose-volume parameters and treatment-related morbidity for women with locally advanced cervical cancer undergoing chemoradiation.

adenocarcinoma
brachytherapy
metastasis
squamous cell carcinoma
adenosquamous carcinoma
  • 0 views
  • 16 Jun, 2022
  • 1 location
A Longitudinal Assessment of Tumor Evolution in Patients With Brain Cancer

The purpose of this study is to test the safety and tolerability of the research study drugs nivolumab, ipilimumab, lomustine, bevacizumab, and temozolomide when used following surgery and before standard therapy with radiation and temozolomide in patients with newly diagnosed high grade glioma. Additional aims of the study are to: …

  • 2 views
  • 06 Jun, 2022
  • 1 location
Multicentered Prospective Randomized Controlled Trial For Solid Pancreatic Lesions

Endoscopic ultrasound (EUS) is an indispensable tool for tissue acquisition for pancreatic lesions. Fine needle aspiration (FNA) is once considered as the first line diagnostic method especially when rapid on-site evaluation (ROSE) by cytopathologist is available. However, FNA alone has several limitations including inadequate acquisition of cells, and unable to …

fine needle biopsy
endoscopic ultrasound
fine needle aspiration
  • 0 views
  • 14 Aug, 2021
  • 1 location