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Found 45 clinical trials
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A Phase 1/2 Multiple Expansion Cohort Trial of MRTX849 in Patients With Advanced Solid Tumors With KRAS G12C Mutation

Evaluates the safety, tolerability, pharmacokinetics, metabolites, pharmacodynamics, and clinical activity of MRTX849 in patients with advanced solid tumors with a KRAS G12C mutation. MRTX849 is an orally-available small molecule inhibitor of KRAS G12C.

advanced solid tumor
malignant solid tumor
solid tumor
  • 538 views
  • 22 Nov, 2021
  • 62 locations
Risk of GAstric Adenocarcinoma After Cephalic Duodenopancreatectomy (RAGAD)

the patient will be considered as a "new case" on the date of histological diagnosis of cancer. Of the patients included in the cohort, some will be eligible to perform the endoscopy added for

  • 0 views
  • 02 Mar, 2022
  • 1 location
An International Clinical Program for the Diagnosis and Treatment of Children With Ependymoma

The overall aim of this project is to improve the outcome of patients diagnosed with ependymoma by improving and harmonising the staging and the standard of care of this patient population and to improve the investigators understanding of the underlying biology thereby informing future treatment. The program will evaluate new …

  • 53 views
  • 21 Oct, 2021
  • 64 locations
Preoperative Preparation With Lugol Solution in Patients With Graves-Basedow Disease. (LIGRADIS)

>Anatomopathological variables: histological diagnosis compatible with GD and existence of parathyroid glands in the surgical specimen. Long-term complications: hypocalcemia and/or permanent vocal cord

body mass index
calcium
antibiotic prophylaxis
methimazole
hyperthyroidism
  • 7 views
  • 28 Feb, 2022
  • 19 locations
Intra-operative Ultrasound Guided Laparoscopic Ovarian Cystectomy as a Method of Fertility Preservation (UGLOC)

Title Intra-operative ultrasound guided laparoscopic ovarian cystectomy (UGLOC) as a method of fertility preservation in the management of benign ovarian cysts. Background Approximately 10% of women in the United Kingdom (UK) will undergo surgery for the presence of an ovarian mass during their lifetime. Ovarian surgery, however, is not without …

Accepts healthy volunteers
  • 8 views
  • 19 Apr, 2022
  • 1 location
Concomitant Immune Check Point Inhibitor With Radiochemotherapy in Head And Neck Cancer

Background: Locally advanced head and neck cancer (HNC) is a challenge as, in spite of initial good control with chemoradiation, the majority of patients fails systemically. In the last 2 years, immune check points inhibitors (mainly Programmed Death (PD)-1 inhibitors) were approved for metastatic/recurrent HNC. The favorable toxicity profile and …

  • 55 views
  • 15 Feb, 2022
  • 1 location
Clinical Trial Evaluating External Evaluation and Training on the Incomplete Resection (POLIPEVA Study) (POLIPEVA)

Introduction It has been shown that some quality indicators in endoscopy can be improved through educational interventions. There are marked differences in the proportion of incomplete polypectomies among endoscopists. The effectiveness of measures to improve it has not been evaluated. objective The main objective is to evaluate whether a training …

polypectomy
cold
endoscopy
colonoscopy
colorectal polyps
  • 0 views
  • 04 Oct, 2022
  • 1 location
Benefit of Enhanced Contact Endoscopy in Pre-histological Diagnosis of Laryngeal and Hypopharyngeal Mucosal Lesions

The focus of the study is to verify the role of enhanced contact endoscopy in early identification of high-risk vascular patterns of precancerous and malignant mucosal changes in ear-nose-throat (ENT) patients, in comparison with other standard imaging techniques.

  • 0 views
  • 08 Jul, 2021
  • 2 locations
Impact of Real-time Notification of Colonoscopic Optical Diagnosis on Patients' Anxiety and Depression After Polypectomy

The accuracy of endoscopic optical diagnosis for colorectal polyps has been approaching histological diagnosis after implementation of image enhancement endoscopic technologies. The real-time

polypectomy
endoscopic resection
depressed mood
colonoscopy
colorectal polyps
  • 0 views
  • 07 Oct, 2022
  • 1 location
  • 0 views
  • 15 Oct, 2022
  • 3 locations