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Found 13 clinical trials
Letrozole in Clomiphene Resistant Infertile Women With Polycystic Ovarian Syndrome

complaint of hirsutism, treatment-resistant acne, menstrual irregularity, acanthosis nigricans, and/or obesity

cardiovascular disease
polycystic ovary syndrome
clomiphene
endometrial carcinoma
letrozole
  • 271 views
  • 26 May, 2022
  • 1 location
Spironolactone Therapy In Young Women With NASH

was selected because it is has been commonly prescribed for decades with good safety profile and tolerability to treat symptoms of high androgens, like acne and hirsutism in young women. Though

testosterone
fatty liver
cirrhosis
  • 37 views
  • 07 Oct, 2022
  • 1 location
Effects of Fasting Mimicking Diet (FMD) in Women With Polycystic Ovary Syndrome (PCOS)

is characterized by hyperandrogenism and/or chronic anovulation which can manifest with a range of symptoms (e.g., hirsutism, acne, oligomenorrhea, and infertility) and is associated with increased

hyperandrogenism
infertility
impaired glucose tolerance
testosterone level
insulin
  • 48 views
  • 22 Mar, 2022
Does Treatment of Androgen Excess Using Spironolactone Improve Ovulatory Rates in Girls With Androgen Excess? (CBS009)

Adolescent girls with androgen excess have a higher rate of irregular periods and decreased ovulation rates compared to normal girls, and are considered at-risk for developing polycystic ovary syndrome (PCOS). This pilot study will look at whether giving spironolactone might improve ovulation rates in girls with androgen excess, ages 13-19. …

hyperandrogenism
infertility
testosterone
hirsutism
testosterone level
  • 1 views
  • 04 Oct, 2022
  • 1 location
The Effect of Polycystic Ovary Syndrome Treatment on Metabolomics

The aim of this study is to determine the effect of the treatment of polycystic ovary syndrome with two different oral contraceptives that contain cyproterone acetate and drospirenone

cyproterone
yasmin
drospirenone
  • 54 views
  • 04 Jun, 2022
  • 1 location
Relative Desirability of Metformin vs. Birth Control Pill in Treating PCOS in Women of Later Reproductive Age (SHK002)

The goal of this study is to determine the relative desirability of metformin vs. oral combined hormonal contraceptives (OCs) in treating Polycystic Ovary Syndrome (PCOS) in women of later reproductive age. Polycystic Ovary Syndrome Questionnaire (PCOSQ) score will be used as a proxy for patient satisfaction. In light of their …

hyperandrogenism
Accepts healthy volunteers
estradiol
diabetes
insulin sensitivity
  • 197 views
  • 15 Feb, 2022
  • 1 location
Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?

The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism (HA), androgen-receptor blockade (spironolactone) alone normalizes sleep-wake luteinizing hormone (LH) pulse frequency (primary endpoint) and overall LH and follicle-stimulating hormone secretion (secondary endpoints).

  • 8 views
  • 04 Oct, 2022
  • 1 location
Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment

The aim of this double-blinded, three-armed randomized controlled trial (RCT) is to evaluate the effects of a 6 months treatment with inositol alone or inositol associated with alpha-lipoic acid in women with polycystic ovary syndrome (PCOS). The study population is composed of 90 women with PCOS (diagnosed according to the …

fasting
insulin
progesterone
testosterone
folic acid
  • 42 views
  • 02 Jun, 2021
  • 1 location
Androgen Excess as a Cause for Adipogenic Dysfunction in PCOS Women

The purpose of this research study is to collect specimen samples and study medical information from women with Polycystic Ovary Syndrome (PCOS) and women without PCOS. The goal is to learn more about the changes that take place in the body that result in PCOS. We anticipate that 32 women …

Accepts healthy volunteers
flutamide
acne
glucose tolerance test
hirsutism
  • 1045 views
  • 23 May, 2022
  • 1 location
Ultrasound Characterization of Ovarian Follicle Dynamics During Weight Loss

The objective of this study is to explore the effects of weight loss on body composition, metabolic status, reproductive hormones, and ovarian follicle development in obese women with regular menstrual cycles versus obese women with irregular menstrual cycles and/or polycystic ovary syndrome (PCOS).

Accepts healthy volunteers
diabetes
reproductive hormones
regular menstrual cycles
insulin
  • 284 views
  • 16 Oct, 2022
  • 1 location