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Found 13 clinical trials
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A Phase 2 Study to Investigate the Safety and Efficacy of ABBV-105 and Upadacitinib Given Alone or in Combination (ABBV-599 Combination) in Subjects with Moderately to Severely Active Systemic Lupus Erythematosus

The purpose of this study is to see if the study drugs, ABBV-105, upadacitinib (ABT-494), or both ABBV-105 and upadacitinib (ABT-494) in combination (ABBV-599) are safe, tolerable, and effective in treating your moderately to severely active systemic lupus erythematosus (SLE).  

  • 23 Nov, 2020
  • 1 location
Extended-Release Buprenorphine vs. Sublingual Buprenorphine for the Treatment of Opioid Use Disorder

more helpful in treating opiate use for individuals testing positive for fentanyl and related high potency drugs (HPSO). Those receiving Sublocade will have it administered monthly and dosing will be

  • 07 Aug, 2021
  • 1 location
Tenofovir Alafenamide Switching Therapy in Kidney or Liver Transplant Recipients With Chronic HBV Infection

tenofovir alafenamide (TAF) has been approved to be highly effective and safe in patients with chronic hepatitis B (CHB), therefore TAF may be a good option in kidney or liver transplant patients with chronic HBV infection. The aim of this prospective cohort study is to assess the safety, efficacy, and …

  • 29 Jun, 2022
  • 1 location
Buprenorphine Induction for Fentanyl Dependent Opioid Users

The overall goal of this pilot study is to characterize illicit fentanyl and combination fentanyl and opioid dependence explicitly, by assessing physiologic barriers to effective buprenorphine induction. Results from this pilot study may make a case for a larger feasibility study to be conducted through the Clinical Trials Network at …

Accepts healthy volunteers
  • 04 Jun, 2022
StrataCTX as a Steroid Sparing Device

The purpose is to determine if StrataCTX can be used as a steroid sparing agent for the treatment of cutaneous reactions related to, cutaneous T Cell lymphoma (CTCL) and chemotherapy/immunotherapy treatments than the current standard treatment - topical steroids in people who are receiving treatment for CTCL, or chemotherapy/immunotherapy for …

topical steroids
  • 20 Aug, 2021
A Phase II Study of Chiauranib in Combine With Capecitabine in TNBC

This study is to evaluate the preliminary efficacy and safety of chiauranib in combine with capecitabine in advanced triple-negative breast cancer failed to prior anthracyclines and taxanes therapy

  • 30 Apr, 2022
  • 1 location
Chiauranib Plus Weekly Paclitaxel in Patients With Platinum-refractory or Platinum-resistant Recurrent Ovarian Cancer (CHIPRO)

This randomized, double-blind, 2-arm study will evaluate the efficacy and safety of Chiauranib plus weekly paclitaxel versus placebo plus weekly paclitaxel in patients with Platinum-refractory or Platinum-resistant Recurrent ovarian cancer.

peritoneal carcinoma
neutrophil count
recurrent ovarian cancer
ovarian epithelial carcinoma
  • 09 Apr, 2022
  • 1 location
Phase Ib/II Study of Chiauranib in Patients With Small Cell Lung Cancer

Chiauranib , which simultaneously targets against VEGFR/Aurora B/CSF-1R, several key kinases involved in tumor angiogenesis, tumor cell mitosis, and chronic inflammatory microenvironment.

international normalized ratio
neutrophil count
cancer chemotherapy
measurable disease
  • 06 Apr, 2022
  • 1 location
Phase 3 Clinical Study of Chiauranib Capsule in Patients With Small-cell Lung Cancer

Chiauranib , which simultaneously targets against VEGFR/Aurora B/CSF-1R, several key kinases involved in tumor angiogenesis, tumor cell mitosis, and chronic inflammatory microenvironment.

  • 18 May, 2022
  • 1 location
Effect of Theta Burst Stimulation on Alcohol Cue Reactivity

Alcohol Use Disorder (AUD) is prevalent, devastating, and difficult to treat. The intransigence of AUD is readily apparent in the Trauma Unit of Wake Forest University Baptist Hospital, wherein 23% of trauma related admissions are associated with alcohol - higher than the national average of 16%. Of these trauma related …

alcohol use disorder
  • 13 May, 2022
  • 1 location