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Found 9 clinical trials
PCSK9 Inhibitor Treatment for Patients With SPG5

Spastic paraplegia type 5 (SPG5) is a rare subtype of hereditary spastic paraplegia, a highly heterogeneous group of neurodegenerative disorders defined by progressive neurodegeneration of the

  • 9 views
  • 16 Feb, 2022
  • 1 location
Spinal Cord Stimulation Therapy for Hereditary Spastic Paraplegias Patients

function and gait in patients with pure Hereditary Spastic Paraplegias.

  • 0 views
  • 22 Mar, 2022
  • 1 location
The Pre-SPG4 Study

Study goals Prospective longitudinal data on progression in the natural course of SPG4 in presymptomatic mutation carriers prior to clinical disease onset and in early stages of disease Biomarkers providing objective measures of disease activity

  • 17 views
  • 07 Oct, 2021
  • 2 locations
Phenotypes, Biomarkers and Pathophysiology in Hereditary Spastic Paraplegias and Related Disorders (HSP-PBP)

The aim of this study is to determine the clinical spectrum and natural progression of Hereditary Spastic Paraplegias (HSP) and related disorders in a prospective multicenter natural history

Accepts healthy volunteers
  • 8 views
  • 28 Feb, 2022
  • 5 locations
Genetic and Physical Study of Childhood Nerve and Muscle Disorders

Background Some nerve and muscle disorders that start early in life (before age 25), like some forms of muscular dystrophy, can run in families. However, the genetic causes of these disorders are not known. Also, doctors do not fully understand how symptoms of these disorders change over time. Researchers want …

x-rays
Accepts healthy volunteers
myopathy
  • 52 views
  • 28 Jul, 2022
  • 1 location
Swiss Cerebral Palsy Registry

The Swiss-CP-Reg is a national patient registry that collects information on diagnosis, symptoms, treatment and follow-up of patients with cerebral palsy (CP) in Switzerland. It was first implemented in 2017 in the paediatric clinics in Basel, Bellinzona, Bern, Geneva, Lausanne, St. Gallen and Zurich. It will be extended to all …

  • 0 views
  • 11 Aug, 2021
  • 8 locations
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)

The purpose of the HSP Sequencing Initiative is to better understand the role of genetics in hereditary spastic paraplegia (HSP) and related disorders. The HSPs are a group of more than 80

spasticity
genetic testing
  • 0 views
  • 16 May, 2022
  • 1 location
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia (HSP)

The Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia (HSP) is focused on gathering longitudinal clinical data as well as biological samples (skin and/or blood and

Accepts healthy volunteers
  • 4 views
  • 21 Jul, 2022
  • 1 location
Phenotype, Genotype and Biomarkers 2 (PGB2)

sclerosis (PLS), hereditary spastic paraplegia (HSP), progressive muscular atrophy (PMA) and multisystem proteinopathy (MSP). More precisely, the investigator wants to identify the links that exist between

atrophy
dementia
hereditary spastic paraplegia
frontotemporal dementia
amyotrophic lateral sclerosis
  • 0 views
  • 10 Jul, 2022
  • 4 locations