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Found 85 clinical trials
Pyrotinib in Combination With Letrozole in Patients With HER2-Positive ER-Positive Metastatic Breast Cancer

This is a prospective, single-arm, multi-center clinical study of pyrotinib in combination With letrozole in patients With HER2-Positive, ER-Positive metastatic breast cancer. Our aim was to explore the efficacy and safety of pyrotinib combined with letrozole in patients with HER2-positive, ER-positive metastatic breast cancer.

hormone therapy
metastasis
endocrine therapy
measurable disease
pertuzumab
  • 0 views
  • 22 Oct, 2021
  • 1 location
Neoadjuvant Multi-epitope HER2 Peptide Vaccine in Patients With HER2-expressing DCIS

This interventional clinical study will examine the safety and efficacy of a degenerate subdominant HER2 specific helper T cell epitope vaccine (H2NVAC) in patients with HER2-expressing ductal carcinoma in situ (DCIS). The ultimate goal of this vaccine is to prevent future invasive breast cancer among patients who are diagnosed with …

cancer
hormone therapy
platelet count
endocrine therapy
raloxifene
  • 20 views
  • 18 Jul, 2021
  • 2 locations
Study of Sequential Systemic Therapy + Intraperitoneal Paclitaxel in Gastric/GEJ Peritoneal Carcinomatosis

This is a phase II clinical trial assessing the safety and efficacy of sequential systemic and intraperitoneal (IP) chemotherapy in patients with primary gastric/gastroesophageal junction cancer with cytology positive peritoneal lavage and/or peritoneal carcinomatosis.

  • 0 views
  • 16 Mar, 2021
  • 1 location
PD-1 Antibody Combined With Modified FLOT Regimen in the Treatment of Unresectable Locally Advanced or Limited Metastatic Gastric Cancer

This study is to evaluate the efficacy and safety of domestic programmed death 1 PD-1 antibody (Camrelizumab for injection) combined with fluorouracil plus leucovorin, oxaliplatin, and albumin bound paclitaxel (modified FLOT, mFLOT) regimen in the treatment of patients with unresectable locally advanced or limited metastatic gastric cancer. The primary efficacy …

oxaliplatin
metastasis
paclitaxel
fluorouracil
leucovorin
  • 0 views
  • 25 Jan, 2021
  • 1 location
Rifaximin for the Treatment of Gastrointestinal Toxicities Related to Pertuzumab-Based Therapy in Patients With Stage I-III HER2 Positive Breast Cancer

This phase II trial studies how well rifaximin works for the treatment of gastrointestinal toxicities related to pertuzumab-based therapy in patients with stage I-III HER2 positive breast cancer. Rifaximin may reduce the incidence and severity of pertuzumab induced gastrointestinal toxicities without interrupting or delaying the chemotherapy schedule.

cancer
platelet count
serum pregnancy test
serum or plasma
docetaxel
  • 0 views
  • 19 Sep, 2021
  • 1 location
The PROMISE Study: Duavee in Women With DCIS

The main purpose of this study is to determine if taking the study drug, conjugated estrogens/bazedoxifene (Duavee) causes any changes in the proliferation markers within the breast tissue of the study subjects. The study drug is approved by the US Food and Drug Administration in healthy postmenopausal women to treat …

cancer
breast cancer
progesterone
hysterectomy
core needle biopsy
  • 264 views
  • 26 Jan, 2022
  • 10 locations
Vinorelbine, Cisplatin, Disulfiram and Copper in CTC_EMT Positive Refractory Metastatic Breast Cancer.

This is a proof-of-concept study to define efficacy of vinorelbine, cisplatin, disulfiram and copper in CTC_EMT positive refractory metastatic hormone receptor positive, HER2 negative breast cancer.

hormone therapy
platelet count
growth factor
breast cancer
liver metastasis
  • 37 views
  • 26 Feb, 2022
  • 1 location
Feasibility of a New Technology for Isolating Circulating Tumour Cells

This is a prospective interventional single-site research with a collection of biological samples. The primary objective of the trial is to assess the ability of the "new technology" to isolating circulating tumor cells (CTC) in selected cancer patients. Five groups will be constitued: at first the Group 0: Healthy volunteers …

cancer
cancer chemotherapy
tumor cells
metastasis
Accepts healthy volunteers
  • 0 views
  • 20 Oct, 2021
  • 1 location
Albumin-bound Paclitaxel and Carboplatin Versus Epirubicin and Docetaxel for Triple-negative Breast Cancer

To investigate the efficacy of albumin-bound paclitaxel combined with carboplatin versus epirubicin combined with docetaxel as neoadjuvant therapy for triple-negative breast cancer.

epirubicin
progesterone
docetaxel
paclitaxel
estrogen receptor
  • 0 views
  • 31 Jul, 2021
  • 7 locations
Albumin-Bound Paclitaxel Combined With Antiangiogenic Agents in First-line Treatment of Relapsed or Metastatic TNBC

This is a prospective, randomized, open-label clinical study. 128 patients with relapsed or metastatic triple-negative breast cancer (TNBC) who had not been systematically treated are going to be enrolled and randomly assigned to 3 groups. Group A: albumin-bound paclitaxel (260mg/m2, intravenous infusion, once every 3 weeks). Group B: albumin-bound paclitaxel …

metastasis
growth factor
measurable disease
paclitaxel
mammogram
  • 0 views
  • 20 Apr, 2022
  • 1 location