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Found 88 clinical trials
Quantitative Assessment of Diffusion Spectrum Imaging in Breast Cancer

(PR), human epidermal growth factor 2 (HER-2), Ki-67, and lymphatic vessel invasion (LVI) status in breast cancer. (3) routine MRI and DSI scans were performed within one week before the pathologic

  • 0 views
  • 24 Dec, 2021
  • 1 location
Combination Neoadjuvant Chemotherapy With or Without Apatinib for HER2 Negative Breast Cancer (APP)

nonmetastatic HER2-negative breast cancer. PURPOSE To explore the efficacy and safety of apatinib added to weekly paclitaxel and cisplatin neoadjuvant therapy for HER-2

adjuvant therapy
paclitaxel
erbb2
breast adenocarcinoma
growth factor
  • 6 views
  • 26 Mar, 2022
  • 1 location
Safety of XELOX Combined With GLS-010 and Lenvatinib in Advanced AFP-positive Gastric Cancer Patients

Cancer Institute and Hospital. In this study, patients with AFP-positive and HER-2-negative advanced gastric cancer who had not received palliative systematic treatment in the past will be enrolled

  • 0 views
  • 24 Mar, 2022
  • 1 location
Leflunomide in Previously Treated Metastatic Triple Negative Cancers

Triple negative breast cancer (TNBC) represents about 15% of breast cancers and is characterized by the lack of expression of estrogen receptor (ER), progesterone receptor (PR), and HER-2 non

metastasis
progesterone
erbb2
estrogen
stage iv breast cancer
  • 10 views
  • 16 Jun, 2022
  • 3 locations
Olaparib With or Without Durvalumab for DDR Gene Mutated Biliary Tract Cancer Following Platinum-based Chemotherapy (OPTIMUM)

metastatic HER-2 negative BRCA mutated breast cancer. For DDR gene mutated advanced biliary tract cancer, olaparib plus durvalumab combination may show synergistic effect with better efficacy than olaparib

  • 0 views
  • 19 Apr, 2022
  • 1 location
ISPY-P1.01:Evaluating the Safety of Weekly Paclitaxel With Trastuzumab Duocarmazine (SYD985) in Patients With Metastatic Cancer

This is an open-label, single-arm, multi-site phase I/Ib trial with SYD985, an antibody-drug conjugate (ADC) targeting HER2 on the cell membrane, combined with paclitaxel.

EGFR
epidermal growth factor
paclitaxel
erbb2
neuropathy
  • 0 views
  • 05 Nov, 2021
  • 24 locations
CAR-macrophages for the Treatment of HER2 Overexpressing Solid Tumors

Phase 1, first-in-human, open label study of CAR macrophages in HER2 overexpressing solid tumors.

bone marrow procedure
cancer
erbb2
HER2
primary cancer
  • 0 views
  • 24 Mar, 2022
  • 5 locations
Oxaliplatin and Liposomal Irinotecan (Plus Trastuzumab for HER2-positive Disease) in Advanced Esophageal and Gastric Adenocarcinoma

This is an open label, phase II, multi-site trial evaluating the efficacy and safety of the combination of 5-FU, oxaliplatin, nal-IRI, and immunotherapy (plus trastuzumab for HER2-positive tumors) as first-line therapy for participants with advanced Esophageal and Gastric Adenocarcinoma (EGA). The investigators hypothesize that this drug combination will be better …

fluorouracil
blood transfusion
oxaliplatin
adenocarcinoma
anticoagulants
  • 0 views
  • 13 May, 2022
  • 1 location
Vaccine Therapy in Treating Patients With Metastatic Solid Tumors

This phase I trial studies the side effects and best dose of vaccine therapy in treating patients with metastatic solid tumors. Vaccines made from antibodies and peptides combined with tumor cells may help the body build an effective immune response to kill tumor cells.

EGFR
metastasis
epidermal growth factor
erbb2
neuropathy
  • 37 views
  • 03 Nov, 2021
  • 1 location
A Study to Investigate Fadraciclib (CYC065), in Subjects With Advanced Solid Tumors and Lymphoma

This is a 2-part, phase 1/2, open-label, multicenter study designed to evaluate the safety, tolerability, PK, pharmacodynamics, PGx, and efficacy of fadraciclib administered orally BID. This study consists of Phase 1 and Phase 2 components in subjects with advanced solid tumors and lymphoma who have progressed despite having standard therapy …

lymphoma
advanced cancer
cancer
  • 2 views
  • 26 Apr, 2022
  • 4 locations