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Found 29 clinical trials
A Multi-institutional Study for Treatment of Children With Newly Diagnosed Hepatoblastoma Using a Modified PHITT Strategy

A Phase 3 multi-institutional study for treatment of children with newly diagnosed hepatoblastoma using a modified Paediatric Hepatic International Tumour Trial (PHITT) strategy incorporating a

renal function
cancer therapy
metastatic disease
cancer
glomerular filtration rate
  • 0 views
  • 27 Mar, 2021
  • 1 location
Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery

This partially randomized phase II/III trial studies how well, in combination with surgery, cisplatin and combination chemotherapy works in treating children and young adults with hepatoblastoma

carcinoma
oxaliplatin
cancer therapy
glomerular filtration rate
cancer
  • 191 views
  • 02 Jul, 2022
  • 130 locations
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists …

tipifarnib
blood transfusion
cytotoxic chemotherapy
iobenguane
sarcoma
  • 1032 views
  • 01 Jul, 2022
  • 106 locations
ET140203 T Cells in Pediatric Subjects With Hepatoblastoma HCN-NOS or Hepatocellular Carcinoma

Open-label, dose escalation, multi-center, Phase I/II clinical trial to assess the safety/tolerability and determine the recommended Phase II Dose (RP2D) of ET140203 T-cells in pediatric subjects who are AFP-positive/HLA-A2-positive and have relapsed/refractory HB, HCN-NOS, or HCC.

carcinoma
measurable disease
  • 0 views
  • 26 Nov, 2021
Paediatric Hepatic International Tumour Trial (PHITT)

The PHITT trial is an over-arching study for patients with Hepatoblastoma (HB) and Hepatocellular Carcinoma (HCC). This trial will use a risk-adapted approach to the treatment of children

carcinoma
oxaliplatin
abdominal compartment syndrome
sorafenib
vincristine
  • 45 views
  • 08 Jun, 2022
  • 2 locations
Flavored Oral Irinotecan VAL-413 (Orotecan ) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors

solid tumors including but not limited to neuroblastoma, rhabdomyosarcoma, Ewing sarcoma, hepatoblastoma and medulloblastoma

temozolomide
antibody therapy
cancer chemotherapy
karnofsky performance status
nitrosourea
  • 9 views
  • 08 Nov, 2021
  • 2 locations
Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies (NYMC195)

Investigators are testing new experimental drug combinations such as the combination of vorinostat, vincristine, irinotecan, and temozolomide in the hopes of finding a drug that may be effective against tumors that have come back or that have not responded to standard therapy. The goals of this study are: To find …

solid tumour
blood transfusion
temozolomide
vincristine
nitrosourea
  • 3 views
  • 01 Mar, 2022
  • 1 location
Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

The phase I portion of this study is designed for children or adolescents and young adults (AYA) with a diagnosis of a solid tumor that has recurred (come back after treatment) or is refractory (never completely went away). The trial will test 2 combinations of therapy and participants will be …

  • 0 views
  • 16 Jun, 2022
  • 2 locations
Neoadjuvant Dual Checkpoint Inhibition and Cryoablation in Relapsed/Refractory Pediatric Solid Tumors

The is a phase II, single arm, open-label, multi-site trial studying the combination of cryoablation therapy and dual checkpoint inhibition with nivolumab (anti-PD-1) and ipilimumab (anti-CTLA-4) given at the recommended phase 2 dose (RP2D) in pediatric and young adult patients with relapsed or refractory solid tumors.

ewing sarcoma family of tumors
antibody therapy
nitrosourea
cytotoxic chemotherapy
cytotoxic t-lymphocyte antigen 4
  • 0 views
  • 19 Apr, 2022
  • 1 location
Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

This phase I/II trial evaluates the highest safe dose, side effects, and possible benefits of tegavivint in treating patients with solid tumors that has come back (recurrent) or does not respond to treatment (refractory). Tegavivint interferes with the binding of beta-catenin to TBL1, which may help stop the growth of …

antibody therapy
vincristine
cytotoxic chemotherapy
iobenguane
stem cell infusion
  • 0 views
  • 09 May, 2022
  • 10 locations