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Found 1365 clinical trials
A Prospective Cohort Study of Patients With Hepatobiliary Cancer Treated With Immune Checkpoint Inhibitors

Although immune checkpoint inhibitors including nivolumab and pembrolizumab are now available for the management of hepatobiliary cancers in Korea, there is a lack of data for the efficacy and safety of these agents in the real-world setting. This study aims to prospectively evaluate the efficacy of safety of nivolumab and …

extrahepatic cholangiocarcinoma
biliary tract cancer
  • 14 Feb, 2022
  • 1 location
The Use of Novel Diagnostic Tools to Increase Detection of Early Fibrosis in Cystic Fibrosis Related Liver Disease to Improve Clinical Management

Cystic Fibrosis (CF) is a genetic condition which affects 1 in 2500 newborn infants and is the commonest genetic condition in the UK. 1 in 25 of the white population carry the mutation. The genetic defect prevents the movement of fluids from cells, leading to thickened secretions and injury. With …

Accepts healthy volunteers
genetic disorder
liver transplant
  • 27 Feb, 2022
  • 1 location
Bariatric Surgery Effect Nonalcoholic Fatty Liver Disease

This is a prospective cohort study, which subjects were obese patients requiring bariatric surgery. The bariatric procedures include laparoscopic sleeve gastrectomy (LSG), laparoscopic Roux-en-Y gastric bypass (LRYGB), and one anastomosis gastric bypass-mini gastric bypass (OAGB-MGB). The main observation is the cure rate of NAFLD:percentage of liver fat content <5% of …

body mass index
fatty liver
hemoglobin a1c
  • 05 Mar, 2022
  • 1 location
Advanced Therapies for Liver Metastases (LiMeT)

Liver metastases (MTS) are the main cause of death for patients affected by colorectal carcinoma (CRC) and pancreatic ductal adenocarcinoma (PDAC), thus representing the major unmet clinical need for these malignancies. Based on preliminary and published data, the investigators hypothesize that innovative immune, gene and cell therapy approaches might overcome …

Accepts healthy volunteers
  • 24 Apr, 2022
  • 1 location
Prospective Cohort Study of Changes in Circulatory MicroRNA of Resected Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the 4th most common cause of cancer death globally but only 20% are diagnosed in its early stages where curative treatment can be carried out. Current standard-of-care surveillance of patients at high risk of developing HCC with 6-monthly serum alpha-fetoprotein (AFP) and ultrasound imaging (US) has …

  • 18 Dec, 2021
  • 6 locations
Clinical Decision and Prognosis Prediction of Hepatocellular Carcinoma by Deep Learning

Developing a deep learning model based on contrast-enhanced ultrasound (CEUS) to predict the prognosis of hepatocellular carcinoma (HCC) and aid choose operation decisions

  • 16 Mar, 2022
  • 1 location
Urinary Tract Infections in Cirrhosis

Evaluate the prevalence and types of urinary tract infections, the features of the gut and urinary tract microbiota in cirrhosis, to assess its importance in the development of complications and outcomes of cirrhosis.

  • 29 Apr, 2022
Determination of Insulin-stimulated Hepatic Glucose Uptake by PET-CT Measurements (ISGU)

In the absence of excessive alcohol consumption, increased levels of fat in the liver (>5%) are diagnosed as non-alcoholic fatty liver (NAFL). It has been shown that NAFL is strongly associated with impairments in metabolic health such as hepatic and whole-body insulin resistance. Insulin resistance is seen as the earliest …

Accepts healthy volunteers
  • 05 May, 2022
  • 1 location
A Long-term Study Evaluating Hepatotoxicity Associated With TURALIO™ (Pexidartinib) Treatment

A study to evaluate the long-term risk of hepatic failure with TURALIO™ (pexidartinib) and the mechanism of liver injury based upon liver biopsy information among patients who received or are receiving TURALIO™ (pexidartinib) and experience hepatotoxicity.

  • 20 Jun, 2022
  • 5 locations
Volume Resuscitation in Cirrhosis With Sepsis Induced Hypotension

In critically ill patients with liver disease like cirrhosis or ACLF, fluid therapy needs to be instituted after identification of patients who will be fluid responsive and initiate appropriate inotropes early to prevent the mortality associated with fluid overload. The parameters and methodology used for assessing fluid responsiveness have been …

liver disease
systolic blood pressure
  • 06 Jun, 2022
  • 2 locations