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Found 1344 clinical trials
Determination of Insulin-stimulated Hepatic Glucose Uptake by PET-CT Measurements (ISGU)

In the absence of excessive alcohol consumption, increased levels of fat in the liver (>5%) are diagnosed as non-alcoholic fatty liver (NAFL). It has been shown that NAFL is strongly associated with impairments in metabolic health such as hepatic and whole-body insulin resistance. Insulin resistance is seen as the earliest …

Accepts healthy volunteers
  • 0 views
  • 05 May, 2022
  • 1 location
Tumor Cell and DNA Detection in the Blood, Urine and Bone Marrow of Patients With Solid Cancers

Patients with resectable solid primary cancers and even limited number of metastases are potentially curable. However, most patients develop recurrences despite surgery. Circulating and disseminated tumor cell (CTC/DTC) and circulating cell-free (cf) DNA isolation from the blood, urine and bone marrow will increase understanding of cancer spread and advance knowledge …

x-rays
Accepts healthy volunteers
skin cancer
metastasis
cancer surgery
  • 68 views
  • 23 Feb, 2022
  • 1 location
Volume Resuscitation in Cirrhosis With Sepsis Induced Hypotension

In critically ill patients with liver disease like cirrhosis or ACLF, fluid therapy needs to be instituted after identification of patients who will be fluid responsive and initiate appropriate inotropes early to prevent the mortality associated with fluid overload. The parameters and methodology used for assessing fluid responsiveness have been …

resuscitation
systolic blood pressure
liver disease
  • 0 views
  • 06 Jun, 2022
  • 2 locations
A Model Based on Computed Tomography Imaging Parameters to Predict Poor Survival in Patients With Liver Cirrhosis

Cirrhosis, as the end stage of most chronic liver diseases, is an important clinical landmark portending high risk of death. Early identification and accurate prognostic scores is critical issue to improve survival rate. Loss of muscle mass and other body features, which can be determined from CT, have been associated …

carcinoma
Accepts healthy volunteers
  • 0 views
  • 03 May, 2022
  • 2 locations
The Use of Novel Diagnostic Tools to Increase Detection of Early Fibrosis in Cystic Fibrosis Related Liver Disease to Improve Clinical Management

Cystic Fibrosis (CF) is a genetic condition which affects 1 in 2500 newborn infants and is the commonest genetic condition in the UK. 1 in 25 of the white population carry the mutation. The genetic defect prevents the movement of fluids from cells, leading to thickened secretions and injury. With …

liver transplant
genetic disorder
Accepts healthy volunteers
liver disease
fibroscan
  • 0 views
  • 27 Feb, 2022
  • 1 location
Clinical Decision and Prognosis Prediction of Hepatocellular Carcinoma by Deep Learning

Developing a deep learning model based on contrast-enhanced ultrasound (CEUS) to predict the prognosis of hepatocellular carcinoma (HCC) and aid choose operation decisions

cancer
  • 0 views
  • 16 Mar, 2022
  • 1 location
Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Hepatorenal Syndrome-Acute Kidney Injury

Point-of-care echocardiography (POC-Echo) is used to determine left ventricular systolic and diastolic dysfunction (LVDD), inferior vena cava (IVC) dynamics and volume status in cirrhosis and Acute-on-chronic liver failure ACLF accurately. We will assess IVC dynamics, LV systolic function [LV ejection fraction (EF) & cardiac output (CO)], and diastolic dysfunction (E/e', …

hepatorenal syndrome
cystatin c
terlipressin
  • 0 views
  • 14 Jul, 2022
  • 1 location
Advanced Therapies for Liver Metastases (LiMeT)

Liver metastases (MTS) are the main cause of death for patients affected by colorectal carcinoma (CRC) and pancreatic ductal adenocarcinoma (PDAC), thus representing the major unmet clinical need for these malignancies. Based on preliminary and published data, the investigators hypothesize that innovative immune, gene and cell therapy approaches might overcome …

Accepts healthy volunteers
  • 0 views
  • 24 Apr, 2022
  • 1 location
Multiparametric Cardio-hepatic MRI in Patients With Noncirrhotic Portal Hypertension

The aim of this study is to use multiparametric MRI to investigate any differences in myocardial structure and function in patients with noncirrhotic portal hypertension compared with a control group with liver cirrhosis.

hypertension
MRI
  • 0 views
  • 23 Sep, 2021
  • 1 location
Bariatric Surgery Effect Nonalcoholic Fatty Liver Disease

This is a prospective cohort study, which subjects were obese patients requiring bariatric surgery. The bariatric procedures include laparoscopic sleeve gastrectomy (LSG), laparoscopic Roux-en-Y gastric bypass (LRYGB), and one anastomosis gastric bypass-mini gastric bypass (OAGB-MGB). The main observation is the cure rate of NAFLD:percentage of liver fat content <5% of …

MRI
liver disease
body mass index
hemoglobin a1c
type 2 diabetes mellitus
  • 0 views
  • 05 Mar, 2022
  • 1 location