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Found 562 clinical trials
Liver Toxicity in Lung Cancer Patients Treated With Immune-checkpoint Inhibitors.

Immune-checkpoint inhibitors have recently become available as a new therapy for a variety of cancers. This drugs function by boosting the anti-cancer immune response, but unfortunately, may cause off-target, non-specific immune activation, resulting in liver and gut toxicity. In order to understand the development of liver immune-related adverse events we …

lung carcinoma
cancer chemotherapy
advanced lung cancer
  • 26 Jan, 2021
  • 3 locations
Enhancing Access to Care for Chronic Hepatitis C Infected Populations in Hong Kong

In the current era of highly effective direct acting antiviral (DAA) therapy, the remaining obstacles to elimination of chronic HCV infection are identification of the high-risk groups, linkage to continued care and prevention of re-infection. It is estimated that 70-80% of patients with chronic HCV are unaware of their infection. …

  • 23 Jan, 2021
Pharmacogenomics of Interferon and Ribavirin Treatment in Patients With Chronic Hepatitis C Virus Infection

The purpose of this study is to examine gene expression profiles by DNA microarray in patients who are responders and non-responders to interferon and ribavirin treatment for hepatitis C virus (HCV). Genes involved in inflammation and fibrosis and mediators of the Th-1 lymphocyte response will be looked for. It is …

chronic hepatitis
  • 07 Nov, 2020
  • 1 location
Methacetin Breath Test in HCV Patients With Normal and Near-Normal ALT

A relatively large proportion of patients with chronic HCV infection have normal or mildly elevated ALT. Many of these patients are not being treated, and are not being sent for a liver biopsy. The present study will determine the ability of Methcetin BreathID Test(MBIT) to detect those patients who will …

  • 07 Nov, 2020
  • 1 location
An US Mathematical Model in Predicting Renal Transplant Rejection

The purpose of this study is to establish an ultrasound mathematical model using acoustic radiation force impulse (ARFI) and contrast-enhanced ultrasonography (CEUS) for diagnosing the status of renal allografts.

contrast-enhanced ultrasound
renal transplant rejection
  • 26 Mar, 2021
  • 1 location
HCV Reinfection in in HIV/HCV-coinfected Patients Achieving SVR by Antiviral Therapy

Chronic hepatitis C virus (HCV) infection remains a health burden in people living with human immunodeficiency virus (HIV). Interferon (IFN)-based therapy is the treatment of choice for HCV infection for HIV coinfected patients in earlier years. However, the treatment responses are far from ideal and the treatment-emergent adverse events (AEs) …

  • 05 Mar, 2021
  • 7 locations
Thrombospondin-4 Levels and Peripheral Arterial Disease in Hemodialysis Patients

Background Peripheral arterial disease (PAD) a condition characterized by atherosclerotic occlusive disease of the lower extremities is commonly observed in patients with chronic kidney disease (CKD) patients, particularly those on dialysis. The investigators conducted detailed biomarkers such as thrombospondin and related inflammatory biomarkers for the risk of developing and presence …

  • 21 Apr, 2021
  • 1 location
'Understanding the Electrophysiological Substrate Underlying Persistent Atrial Fibrillation Study II (USURP AF- Study II)'

Atrial fibrillation (AF) is the most common type of chronic heart rhythm disease worldwide, with significant associated co-morbidities. Although there have been advances in understanding the mechanisms of AF, the underlying cause of AF and factors which perpetuate it remain incompletely understood. This is particularly the case for persistent AF …

persistent atrial fibrillation
catheter ablation
paroxysmal atrial fibrillation
  • 10 May, 2021
  • 1 location
Romanian Kidney Transplant Cardiovascular Risk Registry

Kidney transplantation (KT) represents the best treatment for patients with end-stage kidney disease, being associated with improved outcomes and reduced mortality. Although the survival benefit with KT is mostly attributable to reduction in cardiovascular (CV) disease, KT recipients continue to remain at higher risk for CV-related morbidity and mortality when …

myocardial infarction
kidney transplant
chronic renal failure
  • 24 Jan, 2021
  • 1 location
LiverMultiScan Analysis of MRI Scans in HCC

This project is a pilot study to interrogate the potential of LMS as a predictive tool for the selection of therapy for HCC patients. The reliability of LMS to predict patients' response following HCC therapy will leverage on an algorithm that is built from the pool of MRI scans from …

systemic therapy
primary liver cancer
platelet count
  • 24 Jan, 2021