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Found 9 clinical trials
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Hyperbaric Oxygen Therapy for Hemorrhagic Cystitis Post HSCT

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for many malignant or nonmalignant hematological diseases. Hemorrhagic cystitis (HC) is one of

cell transplantation
hemorrhagic cystitis
acute graft-versus-host disease
tissue damage
clot formation
  • 1 views
  • 18 Sep, 2021
  • 1 location
None
Study to Evaluate Viralym-M (ALVR105) for the Treatment of Virus-Associated Hemorrhagic Cystitis (HC)

A study to evaluate ALVR105 (Viralym-M); an allogeneic, off-the-shelf multi-virus specific T cell therapy that targets six viral pathogens: BK virus, cytomegalovirus, adenovirus, Epstein-Barr virus, human herpesvirus 6 and JC virus.

  • 0 views
  • 20 Oct, 2021
  • 29 locations
None
The Safety Tolerability and Efficacy of LP-10 in Subjects With Refractory Moderate to Severe Hemorrhagic Cystitis

The purpose of this study is to assess the safety and tolerability of three doses of LP-10 (intravesical tacrolimus). Twelve subjects meeting the inclusion and exclusion criteria will be enrolled and treated in a prospective and multi-center trial with LP-10. The proposed trial will recruit 12 subjects in a dose-escalation …

  • 0 views
  • 10 Nov, 2021
  • 4 locations
None
Trial Evaluating the Efficacy of Systemic Mesenchymal Stromal Cell (MSC) Injections for the Treatment of Severe and Chronic Radiotherapy-induced Abdomino-pelvic Complications (Pelvic Radiation Disease PRD) Refractory to Standard Therapy

treat hemorrhagic cystitis, proctopathy have demonstrated the feasibility to used MSCs in these pathologies : MSCs successfully repair hemorrhagic cystitis, and perforated colon in

  • 0 views
  • 11 Aug, 2021
  • 2 locations
None
HBOT in the Treatment and Prevention of aGVHD

effective and economical therapeutic modality for hemorrhagic cystitis (HC) whether induced by infection or acute graft-versus-host disease (aGVHD) for transplant recipients. However, little is known about

  • 0 views
  • 21 Oct, 2021
  • 1 location
None
Clinical Study of MMF in Treatment of IIM-ILD and Its Effect on Peripheral Blood Treg Cells

and side effects. It is prone to gonadal inhibition, infection, tumor, hemorrhagic cystitis and other risks. At present, Mycophenolate mofetil (MMF) has been widly used in the treatment of IIM

myopathy
forced vital capacity
ciclosporin
fibrosis
azathioprine
  • 0 views
  • 30 Nov, 2021
  • 1 location
None
Adoptive Cord Blood Immunotherapy for EBV CMV BKV and Adenovirus Reactivation/Infection or Prophylaxis

This Phase I-II dose-finding trial to determine the optimal dose of intravenous (IV) injection dose of donor-derived cytotoxic T lymphocytes (CTLs) specific for CMV, EBV, BKV and Adenovirus. A maximum of 36 patients will be treated in up to 18 cohorts each of size 2, with the first cohort treated …

absolute neutrophil count
nephropathy
cmv infection
  • 63 views
  • 15 Aug, 2021
  • 2 locations
None
T-Lymphocytes for Prevention or Treatment of Viral Infections Following Hematopoietic Stem Cell Transplantation

This Phase I dose-escalation trial is designed to evaluate the safety of rapidly generated multivirus-specific T-cell products with antiviral activity against CMV, EBV, adenovirus, HHV6, BK virus, JC virus, and human parainfluenza-3 (HPIV3), derived from eligible HSCT donors. In this trial, we will utilize a rapid generation protocol for broad …

antiviral drugs
stem cell transplantation
prednisone
parainfluenza
cmv infection
  • 54 views
  • 22 Oct, 2021
  • 1 location
None
Target Busulfan Exposure in Children With HSCT in China

Objectives To evaluate the correlation between BU exposure and post-transplant clinical results (efficacy and safety) to establish the optimal BU treatment window for myeloablative conditioning in Chinese pediatrics, provide theoretical basis and the new strategy for BU individualized dosage, further optimize transplant treatment and reduce drug-related toxicity. Population 500 participants …

  • 0 views
  • 19 Mar, 2021
  • 1 location