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Found 31 clinical trials
Zanubrutinib for HLH

This study is a prospective single-arm clinical study, focusing on Hemophagocytic lymphohistocytosis,to evaluate the clinical efficacy and safety of zanubrutinib.

  • 0 views
  • 27 Apr, 2022
  • 1 location
  • 0 views
  • 16 Mar, 2022
  • 1 location
Use Of A Response-Adapted Ruxolitinib-Containing Regimen For The Treatment Of Hemophagocytic Lymphohistiocytosis

etoposide as Frontline therapy for patients with newly diagnosed hemophagocytic lymphohistiocytosis (HLH) or as Salvage therapy for patients with relapsed/refractory HLH. Primary Objective

  • 6 views
  • 04 Oct, 2022
  • 10 locations
Efficacy and Safety of Venetoclax Combined With Dexamethasone and Etoposide in the Treatment of Hemophagocytic Lymphohistiocytosis

This study aimed to investigate the efficacy and safety of venetoclax combined with dexamethasone and etoposide as a salvage therapy for hemophagocytic lymphohistiocytosis.

  • 0 views
  • 17 Oct, 2022
  • 1 location
Evaluation of the Safety and Efficacy of ELA026 in Patients With Secondary Hemophagocytic Lymphohistiocytosis

Hemophagocytic lymphohistiocytosis is a rare, aggressive and life-threatening syndrome of excessive immune activation. ELA026 is a fully human IgG1 SIRP-directed monoclonal antibody designed to

  • 0 views
  • 04 Oct, 2022
  • 3 locations
Treatment of Non Severe Hemophagocytosis Lymphohistiocytosis With ITACITINIB (HLH-JAK)

This project aims to test the effectiveness of ITACITINIB in sporadic Hemophagocytosis Lymphohistiocytosis (HLHs)

  • 0 views
  • 04 Oct, 2022
  • 1 location
Rec-LH PD and Safety Profile in Hypogonadotropic Hypogonadism Men (RHYTHM)

Objectives The overall clinical question is whether LH supplementation to men in indication for FSH according to the AIFA note 74, or with HH, will improve spermatogenesis and pregnancy rate (spontaneous or after ART) over FSH alone or FSH+hCG. However, since LH has never been used in men so far, …

  • 0 views
  • 05 Mar, 2022
An Open-label, Single-arm, Multicohort, Phase 2 Study to Assess the Efficacy and Safety of Tabelecleucel in Subjects With Epstein-Barr Virus-associated Diseases

The purpose of this study is to assess the efficacy and safety of tabelecleucel in participants with Epstein-Barr virus (EBV) associated diseases.

measurable disease
cancer
cancer chemotherapy
colony stimulating factor
systemic disease
  • 1 views
  • 11 Oct, 2022
  • 37 locations
Evaluate Efficacy, Safety and Tolerability, PK and PD of Emapalumab in Children and Adults With MAS in Still's or SLE (EMERALD)

The purpose of this study is to assess the safety, tolerability and efficacy of emapalumab in children and adults with macrophage activation syndrome (sHLH/MAS) in Still's disease (including systemic juvenile idiopathic arthritis and adult onset Still's disease) or with sHLH/MAS in systemic lupus erythematous, resenting an inadequate response to high …

lupus
arthritis
  • 0 views
  • 07 Oct, 2022
  • 26 locations
Chidamide Combines With VP-16 and Methylprednisolone in the Treatment of HLH

Chidamide combines with VP-16 and methylprednisolone in HLH

  • 0 views
  • 05 Dec, 2021
  • 1 location