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Found 51 clinical trials
Paroxysmal Nocturnal Hemoglobinuria in ESUS & ETUS

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired clonal hematological disorder, which can cause arterial or venous thrombosis. The frequency of PNH in young patients (< 50 years old) with embolic stroke (ESUS), transient ischemic attack (ETUS) or superior sagittal sinus cerebral venous thrombosis (SSS-CVTUS) of undetermined source, is currently …

embolism
ischemia
diffusion weighted imaging
deficit
paroxysmal nocturnal hemoglobinuria
  • 3 views
  • 26 May, 2022
  • 1 location
Registry on the EXperience of Extracorporeal CO2 Removal in Intensive Care Units (REXECOR)

Investigators will aim to conduct an observational study in order to assess very thoroughly all patients implanted by Extracorporeal carbon dioxide removal (ECCO2R) in 10 critical care units of Paris and its surburb (APHP, Assistance Publique des hpitaux de Paris). Secondary objectives will be: to assess efficacy and safety of …

Accepts healthy volunteers
  • 0 views
  • 13 Feb, 2022
  • 1 location
Incidence of Snakebite Associated Thrombotic Microangiopathy & Role of Peripheral Blood Smear as a Predictor of Clinical Outcome

The aim of this study is to find the overall incidence of thrombotic microangiopathy in snakebite victims. As we know snakebite is a common in tropical regions. Many a times the early diagnosis of TMA is missed and precious time which could have helped in improving the patient prognosis is …

  • 0 views
  • 24 Jun, 2021
  • 1 location
Adding Azathioprine/Hydroxyurea Preconditioning to Alemtuzumab/TBI to Reduce Risk of Graft Failure in MSD HSCT in Adult SCD Patients

In this study the investigators will prospectively investigate whether the addition of a 3-months long preconditioning with azathioprine to the alemtuzumab/TBI non-myeloablative conditioning results in improved disease-free survival and donor chimerism after allo-SCT in SCD patients. Furthermore, the investigators will evaluate whether azathioprine/hydroxyurea preconditioning leads to more patients being able …

hydroxyurea
alemtuzumab
sirolimus
thalassemia
cell transplantation
  • 0 views
  • 15 Mar, 2022
  • 1 location
The Pharmacokinetics and Pharmacodynamics of Eculizumab in Patients With Paroxysmal Nocturnal Hemoglobinuria

Because of the inter and intra individual variability in pharmacokinetics and pharmacodynamics of eculizumab in PNH patients, a tailored treatment approach for the individual is probably preferable. The starting point of a robust tailored dosing approach for eculizumab is the development of a population pharmacokinetic-pharmacodynamic model. In this cross-sectional observational …

eculizumab
  • 0 views
  • 02 Jul, 2021
  • 1 location
Prospective Observational Study of Long-term Pathogenic Treatment of Elizaria® (NAP)

This is prospective observational study of long-term pathogenic treatment of Elizaria® in patients with paroxysmal nocturnal hemoglobinuria.

  • 0 views
  • 26 Mar, 2022
  • 8 locations
Dynamics of Platelet Activation in Patients With Ventricular Assist Device (VAD) (PASVAD)

Consenting patients with end-stage heart failure that are implanted with/candidates for implant of a short-term/durable mechanical circulatory support device (e.g.: percutaneous microaxial pumps (Impella), extracorporeal membrane oxygenator (ECMO), Ventricular Assist Device (VAD) will be enrolled in the study. Aim of the study is to evaluate the patients' haemostatic and coagulation …

hemostatic
coagulation test
heart failure
Accepts healthy volunteers
  • 0 views
  • 17 May, 2022
  • 1 location
Cerebrovascular Reserve and White Matter Disease in Patients With Chronic Anemia (CVR)

This is primarily an observational trial in patients with chronic anemia syndromes (sickle cell disease and thalassemia) and control subjects. The key purpose is to understand how brain blood flow reserve (the ability of the brain to increase its flow in response to stress) is altered in patients with chronic …

hydroxyurea
anemia
acetazolamide
Accepts healthy volunteers
blood transfusion
  • 18 views
  • 15 Feb, 2022
  • 1 location
Transfusion Treatment in Patients With SCD

The "National Transfusion Treatment Survey in patients with sickle cell disease (SCD)" is a prospective longitudinal systemic study that was created in order to evaluate the therapeutic approach, mainly transfusional, in patients affected by SCD throughout Italy and to improve the quality of care and implement research. The survey will …

  • 0 views
  • 11 May, 2022
  • 1 location
Destiny: D-dimer. Investigating D-dimer Levels Using Point-of-Care (POC) Testing at Primary Care.

DESTINY D-Dimer is an observational feasibility study, and a collaboration between the University of South Wales and Cwm Taf Morgannwg University Health Board (CTMUHB). The study is based at St. John's Medical Practice in Aberdare, where participant recruitment will take place. Blood D-dimer data will be collected from CTMUHB Pathology …

cancer
d-dimer
clot
  • 0 views
  • 15 Nov, 2021
  • 2 locations