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Found 51 clinical trials
Interest of Famotidine in Children With Sickle Cell Disease (FAMODREP)

The purpose of this study is to determine whether oral famotidine, a histamine type 2 receptor antagonist already widely used with very few side effects in other indications in children, is effective in reducing endothelial expression of P-selectin in children with sickle cell disease (SCD). This pilot study will constitute …

voxelotor
vaso-occlusive crisis
glutamine
priapism
chest syndrome
  • 0 views
  • 15 Mar, 2022
The Safety of Repurposing Daratumumab for Relapsed or Refractory Autoimmune Antibody Mediated Hemolytic Anemia (DARA-AIHA)

A single-arm study utilizing a 6 x 4 expansion design using daratumumab SC treatment for patients with refractory Autoimmune Hemolytic Anemia.

  • 0 views
  • 02 Jul, 2022
  • 1 location
The Congenital Dyserythropoietic Anemia Registry (CDAR)

The investigators propose the creation and maintenance of a comprehensive registry for patients with the diagnosis of Congenital Dyserythropoietic Anemia (CDA) in North America. The goal of this registry will be to collect long-term confidential data on patients with CDA in the US, Canada, and Mexico and create a bio-repository …

Accepts healthy volunteers
  • 21 views
  • 24 Feb, 2022
  • 1 location
The Impact of Age-dependent Haptoglobin Deficiency on Plasma Free Hemoglobin Levels During Extracorporeal Membrane Oxygenation Support

circulated throughout the body even if the heart is unable to do so. Unfortunately, ECMO can cause breakdown of the red blood cells (known as hemolysis). For unclear reasons, newborns are at particularly

acute respiratory failure
carbon dioxide
endotracheal extubation
membrane oxygenation
  • 11 views
  • 23 Mar, 2022
  • 1 location
Data Registry of Auto Immune Hemolytic Anemia (DRAIHA)

In autoimmune hemolytic anemia (AIHA) auto-antibodies directed against red blood cells (RBCs) lead to increased RBC clearance (hemolysis). This can result in a potentially life-threatening

Accepts healthy volunteers
  • 4 views
  • 12 Feb, 2022
  • 1 location
G6PD Deficiency in Infarction Patients in Shaanxi Province (GPS-IP)

secondary prevention of cerebral infarction. G6PD deficiency is a rare genetic disorder, patients with this disorder could suffer hemolysis after eating broad beans. Professor Zeng Jinsheng et al found that

  • 0 views
  • 13 May, 2022
Operational Feasibility of Appropriate Radical Cure of Plasmodium Vivax With Tafenoquine or Primaquine After Quantitative G6PD Testing in Brazil (Trust)

, TQ treatment and signs of hemolysis. The retrospective data from all patients will be entered into a new database by the municipality staff during the study period and the relevant data will be

  • 0 views
  • 27 Apr, 2022
  • 4 locations
Screening for Alpha Thalassemia in Healthy Volunteers

Background Alpha thalassemia is a blood disorder. It is caused by genetic deletions. Part of the DNA is missing from a group of genes called alpha globin. Alpha thalassemias are some of the most common genetic deletions. We are testing for alpha thalassemia trait. Alpha thalassemia trait is when someone …

Accepts healthy volunteers
anemia
decitabine
blood disorder
cancer
  • 78 views
  • 28 Jun, 2022
  • 1 location
Heart Arteries and Sickle Cell Disease / Coeur Artères DREpanocytose (CADRE)

The CADRE study is a multinational observational cohort of patients with sickle-cell disease (SCD) in five west and central sub-Saharan African countries. The aim of this project is to describe the incidence and assess the predictive factors of SCD-related micro- and macro-vascular complications in sub-Saharan Africa.

Accepts healthy volunteers
  • 62 views
  • 26 Jan, 2022
  • 10 locations
ERYthrocyte Morphology Using Flow Imaging on ImageSTREAM Cytometer (ERYSTREAM)

anemias for example, it allows the recognition of therapeutic emergencies such as sickle cell disease crisis, malaria-induced hemolysis and thrombotic microangiopathy, the latter being characterized by

  • 0 views
  • 22 Apr, 2022
  • 1 location