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Found 51 clinical trials
Safety and Efficacy of Different Regimens of Primaquine on Vivax Malaria Treatment in G6PD Deficient Patients

treatment safety among groups. All groups will be actively monitored for hemolysis during treatment and will have six-month follow-up period to assess treatment efficacy.

glucose-6-phosphate dehydrogenase
g6pd deficiency
primaquine
hemolysis
chloroquine
  • 37 views
  • 12 Apr, 2022
  • 2 locations
Effect of Exercise on Biomarkers in SCT

This study measures the effect of exercise on a variety of biomarkers in blood and urine selected to evaluate the physiological pathways of hemolysis, myolysis, thrombosis, inflammation, and

sickle cell trait
hemolysis
Accepts healthy volunteers
  • 0 views
  • 22 Mar, 2022
  • 1 location
The Use of Eculizumab in HELLP Syndrome

This research study is being performed to see if women diagnosed with early preterm Hemolysis, Elevated Liver Enzymes, Low Platelets (HELLP) syndrome (estimated gestational ages of 23-30 weeks

  • 0 views
  • 22 Jun, 2021
  • 1 location
Efficacy of Prolonged Anticoagulation for Primary Prevention of Venous Thromboembolic Disease in Autoimmune Hemolytic Anemia: a Prospective, Phase II, Randomized, Multicenter Study (API-AHAI)

highest during the period of hemolysis, especially during the first 3 months after the diagnosis of AIHA. This risk is 7.5 [4.7; 12.0] times greater than in the general population. No clinical predictive

cancer
  • 0 views
  • 22 Mar, 2022
  • 1 location
Effect of Iron-fortified Pea Powder on Exercise Performance

Female endurance athletes are susceptible to iron deficiency and this can impact their exercise performance. This study assesses the impact of an pea protein supplement with high iron bio-availability on iron status and exercise performance.

Accepts healthy volunteers
  • 0 views
  • 25 May, 2022
  • 1 location
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat

Background Sickle cell disease (SCD) is a disorder that causes episodes of acute pain and progressive organ damage. Ways to manage SCD have evolved slowly. Treatments do not always work. Researchers want to see if a drug called mitapivat can help people with SCD. Objective To test the long-term tolerability …

glomerular filtration rate
blood transfusion
absolute neutrophil count
a hemoglobin
hemolysis
  • 0 views
  • 18 Jun, 2022
  • 1 location
Effects of Prolonged Delivery of Nitric Oxide Gas on Plasma Reduction-Oxidation Reactions in Cardiac Surgical Patients

This study is an ancillary (add-on) study to the clinical trial entitled "Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction", which has Clinical Trials.gov identifier NCT02836899. NCT02836899 trial randomizes cardiac surgical patients to receive either Nitric Oxide (NO) or a placebo during and after cardiac surgery. This …

cardiopulmonary bypass
nitric oxide
endothelial dysfunction
cardiac surgery
  • 0 views
  • 13 Feb, 2022
Red Blood Cell Survival in Sickle Cell Disease

This is a single-arm, mechanistic clinical trial to measure predictors of senescence and the in vivo survival of transfused red blood cells (RBCs) in individuals with sickle cell disease (SCD) receiving chronic transfusion therapy (CTT). Chronic transfusion in patients with SCD is a common treatment. The efficacy of RBC transfusion …

sickle hemoglobin
thalassemia
blood transfusion
  • 0 views
  • 26 Jan, 2022
  • 3 locations
TRC102 and Temozolomide for Relapsed Solid Tumors and Lymphomas

Background TRC102 is a new cancer treatment drug that may help improve the results of chemotherapy. It blocks tumor cells' attempts to repair damaged DNA, which may allow chemotherapy to kill the cells more easily. Researchers want to see how well it works with temozolomide, a chemotherapy drug that is …

bisphosphonate
liver metastasis
cancer treatment
blood transfusion
nitrosoureas
  • 13 views
  • 01 Jul, 2022
  • 1 location
Low Dose Iron Chelation as TReatment of Oxidative Damage in Sickle Cell Disease (TROS)

Objective To study the safety and efficacy of deferasirox as treatment of oxidative stress in adult subjects with sickle cell disease. Endpoints The investigators will determine whether treatment with iron chelators results in decreased sickling of RBCs, oxidative stress, neutrophil activation, inflammation, endothelial activation and hypercoagulability and ultimately reduced disease …

iron
thalassemia
thal
  • 0 views
  • 05 Jun, 2022