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Found 220 clinical trials
Serological Screen and Treat Trial for Plasmodium Vivax (SSAT)

This is a clinical trial to evaluate an experimental serological diagnostic technique intended to identify people at high risk of having dormant malaria parasites in their liver. The study is designed to evaluate the efficacy of serological screening vs. routine care for the prevention of recurrent P. vivax infections. A …

Accepts healthy volunteers
  • 0 views
  • 10 Mar, 2022
  • 1 location
Pilot Study PBSCT With TCRab Depletion For Hemoglobinopathies

This is a single arm pilot study of peripheral stem cell transplantation (PSCT) with ex vivo t-cell receptor alpha beta+(TCRαβ+) T cell and cluster of differentiation 19+ beta (CD19+ B) cell depletion of unrelated donor (URD) grafts using the CliniMACS device in patients with sickle cell disease (SCD) and beta …

blood transfusion
hemoglobin s
hydroxyurea
cell transplantation
hemoglobin ss
  • 0 views
  • 25 Mar, 2022
  • 1 location
Hematopoietic Stem Cell Transplant for High Risk Hemoglobinopathies

This is a study to collect the outcomes of stem cell transplantation for patients with hematologic diseases other than cancer.

anemia
antithymocyte globulin
cyclophosphamide
cell transplantation
total body irradiation
  • 231 views
  • 22 Apr, 2022
  • 1 location
Pre-transplant Immunosuppression and Donor Stem Cell Transplant for the Treatment of Severe Hemoglobinopathies

This clinical trial studies the effect of pre-transplant immunosuppression (PTIS) and donor stem cell transplant in treating patients with severe blood diseases (hemoglobinopathies). PTIS helps

tacrolimus
hemoglobinopathy
electrophoresis
chest syndrome
stroke
  • 0 views
  • 26 Jan, 2022
  • 1 location
EDIT-301 for Autologous HSCT in Subjects With Severe Sickle Cell Disease

The purpose of this study is to evaluate the efficacy, safety and tolerability of treatment with EDIT-301 in adult subjects with severe sickle cell disease (SCD).

busulfan
vaso-occlusive crisis
hydroxyurea
  • 0 views
  • 29 Apr, 2022
  • 11 locations
A Blood Stem Cell Transplant for Sickle Cell Disease

Blood stem cells can produce red blood cells (which carry oxygen), white blood cells of the immune system (which fight infections) and platelets (which help the blood clot). Patients with sickle cell disease produce abnormal red blood cells. A blood stem cell transplant from a donor is a treatment option …

blood transfusion
antithymocyte globulin
hemoglobin s
hydroxyurea
cyclophosphamide
  • 71 views
  • 03 Mar, 2022
  • 1 location
TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Non-Malignant Hematological Disorders in Children

This research is being done to learn if a new type of haploidentical transplantation using TCR alpha beta and CD19 depleted stem cell graft from the donor is safe and effective to treat the patient's underlying condition. This study will use stem cells obtained via peripheral blood or bone marrow …

blood transfusion
anemia
hemoglobin s
gilbert's syndrome
hydroxyurea
  • 0 views
  • 15 Sep, 2021
  • 1 location
Reduced Intensity Conditioning (RIC) Regimen for Patients With Non-malignant Disorders (RIC)

This is a Phase II pilot study to evaluate engraftment and toxicity of patients with non-malignant diseases using a reduced intensity conditioning regimen in the setting of allogeneic transplant for non malignant diseases. Bone Marrow or cord blood will be acceptable as a stem cell source. Recently, reduced intensity conditioning …

histiocytosis
shortening fraction
transplant conditioning
immunodeficiency
fludarabine
  • 1 views
  • 08 Apr, 2022
  • 1 location
Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases

The hypothesis for this study is that a preparative regimen that maximizes host immunosuppression without myeloablation will be well tolerated and sufficient for engraftment of donor hematopoietic cells. It is also to determine major toxicities from these conditioning regimens, within the first 100 days after transplantation.

graft versus host disease
hemoglobin s
hydroxyurea
transplant conditioning
campath
  • 142 views
  • 24 Jan, 2022
  • 20 locations
Second or Greater Allogeneic Hematopoietic Stem Cell Transplant Using Reduced Intensity Conditioning (RIC)

This is a treatment guideline for a second or greater allogeneic hematopoietic stem cell transplant (HSCT) using a reduced intensity conditioning (RIC) in patients with non-malignant or malignant diseases. This regimen, consisting of busulfan, fludarabine, and low dose total body irradiation (TBI), is designed to promote engraftment in patients who …

myeloablative conditioning
granulocyte colony stimulating factor
busulfan
total body irradiation
fludarabine
  • 17 views
  • 21 Jul, 2021
  • 1 location