Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 201 clinical trials
Interferon and Ribavirin Treatment in Patients With Hemoglobinopathies

Worldwide, several studies report that 4.4% to 85.4% of thalassemia patients were positive for anti hepatitis C antibodies. Recently, three different studies reported the efficacy and the safety of combination therapy with pegylated interferon and ribavirin in thalassemic patients. This study is carried ahead to assess the impact of combination …

hepatitis b
ribavirin
thalassemia
  • 0 views
  • 07 Nov, 2020
  • 1 location
A Safety and Efficacy Study Evaluating CTX001 in Subjects With Severe Sickle Cell Disease

This is a single-arm, open-label, multi-site, single-dose Phase 1/2 study in subjects with severe sickle cell disease (SCD). The study will evaluate the safety and efficacy of autologous CRISPR-Cas9 Modified CD34+ Human Hematopoietic Stem and Progenitor Cells (hHSPCs) using CTX001.

vaso-occlusive crisis
busulfan
ctx001
stem cell transplantation
  • 82 views
  • 27 Jan, 2021
  • 14 locations
A Safety and Efficacy Study Evaluating CTX001 in Subjects With Transfusion-Dependent -Thalassemia

This is a single-arm, open-label, multi-site, single-dose Phase 1/2 study in subjects with transfusion-dependent -thalassemia (TDT). The study will evaluate the safety and efficacy of autologous CRISPR-Cas9 Modified CD34+ Human Hematopoietic Stem and Progenitor Cells (hHSPCs) using CTX001.

stem cell transplantation
ctx001
thalassemia
beta thalassemia
busulfan
  • 74 views
  • 22 Feb, 2021
  • 12 locations
INTERCEPT Blood System for RBCs Study in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections

Stage A: To evaluate the safety and efficacy of red blood cells (RBCs) prepared with the INTERCEPT Blood System for Red Blood Cells Pathogen Reduction Treatment (PRT) in comparison to conventional RBCs in patients who require RBC transfusion support. Stage B: To provide early access to the INTERCEPT pathogen reduction …

sepsis
blood transfusion
  • 196 views
  • 10 Apr, 2021
  • 11 locations
Pilot Study PBSCT With TCRab Depletion For Hemoglobinopathies

This is a single arm pilot study of peripheral stem cell transplantation (PSCT) with ex vivo t-cell receptor alpha beta+(TCR+) T cell and cluster of differentiation 19+ beta (CD19+ B) cell depletion of unrelated donor (URD) grafts using the CliniMACS device in patients with sickle cell disease (SCD) and beta …

thalassemia
hemoglobin c disease
beta thalassemia
hemoglobin s
hemoglobin ss
  • 0 views
  • 26 Jan, 2021
  • 1 location
Hematopoietic Stem Cell Transplant for High Risk Hemoglobinopathies

This is a study to collect the outcomes of stem cell transplantation for patients with hematologic diseases other than cancer.

anti-thymocyte globulin
thalassemia
cancer
fludarabine
sickle cell anemia
  • 99 views
  • 26 Jan, 2021
  • 1 location
Pre-transplant Immunosuppression and Donor Stem Cell Transplant for the Treatment of Severe Hemoglobinopathies

This clinical trial studies the effect of pre-transplant immunosuppression (PTIS) and donor stem cell transplant in treating patients with severe blood diseases (hemoglobinopathies). PTIS helps

  • 0 views
  • 18 Mar, 2021
  • 1 location
EDIT-301 for Autologous HSCT in Subjects With Severe Sickle Cell Disease

The purpose of this study is to evaluate the efficacy, safety and tolerability of treatment with EDIT-301 in adult subjects with severe sickle cell disease (SCD).

  • 0 views
  • 05 May, 2021
  • 1 location
A Blood Stem Cell Transplant for Sickle Cell Disease

Blood stem cells can produce red blood cells (which carry oxygen), white blood cells of the immune system (which fight infections) and platelets (which help the blood clot). Patients with sickle cell disease produce abnormal red blood cells. A blood stem cell transplant from a donor is a treatment option …

osteonecrosis
anti-thymocyte globulin
thalassemia
transcranial doppler ultrasonography
asthma
  • 71 views
  • 13 Mar, 2021
  • 1 location
TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Non-Malignant Hematological Disorders in Children

This research is being done to learn if a new type of haploidentical transplantation using TCR alpha beta and CD19 depleted stem cell graft from the donor is safe and effective to treat the patient's underlying condition. This study will use stem cells obtained via peripheral blood or bone marrow …

hematologic disorders
bone marrow failure syndromes
thrombasthenia
oximetry
thalassemia
  • 0 views
  • 24 Jan, 2021
  • 1 location