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Found 88 clinical trials
Human Solute Carrier Family 5 Member 2 (SLC5A2) Deficiency and the Glucagon-Incretin Axis

Sodium-glucose-cotransporter 2 (SGLT2) are a new type of oral antidiabetic drugs. SGLT2 inhibitors increase the urinary glucose excretion and thereby decrease blood glucose levels. Beside their glucose lowering effects SGLT2 inhibitors showed beneficial effects on the cardiovascular health. But several studies in cell culture and mice showed that the physiological …

antidiabetic agents
  • 23 Jan, 2021
  • 1 location
Pilot Study-Magnetic Resonance Imaging for Global Atherosclerosis Risk Assessment

Cardiovascular disease (CVD) remains the leading cause of death in the United States, and improved CVD risk assessment is needed for personalized medicine. Atherosclerosis measures including plaque volume and adverse plaque features have prognostic value. Novel techniques have been developed for assessing carotid, coronary, and femoral atherosclerosis using magnetic resonance …

cardiovascular disease
coronary disease
  • 25 Jan, 2021
  • 1 location
Eliminating the Need for Pancreas Biopsy Using Peripheral Blood Cell-free DNA

Donor-derived cell-free DNA (dd-cfDNA) has shown promise as an early marker for cellular injury caused by rejection. dd-cfDNA changes may also indicate other injuries that lead to progressive decline in transplant organ function associated with, in the case of kidney transplantation, the presence of interstitial fibrosis (IF) and tubular atrophy …

  • 07 May, 2021
  • 1 location
Heritability of Fatty Liver as Measured by MRI: a Cross Sectional Study of Twins and Family Members

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the United States. The cause of NAFLD is poorly defined but is thought to involve complex interactions of genetic and environmental factors. NAFLD is often associated with the traits of the metabolic syndrome including diabetes, high cholesterol or …

  • 15 May, 2021
  • 1 location
Biofilm Modified Macrophage Phenotype and Function in Diabetic Wound Healing

The purpose of this study is to learn more about biofilm and to see how it affects diabetic wounds. A biofilm can occur if a chronic infection causes bacteria to grow in a slime enclosed group. This grouping of bacteria is called a biofilm.

hemoglobin a1c
glycosylated hemoglobin
negative pressure wound therapy
chronic infection
  • 05 Mar, 2021
  • 2 locations
Ultrasound Characterization of Ovarian Follicle Dynamics in Women With Amenorrhea

In women with regular menstrual cycles, antral follicles have been shown to grow in synchronous cohorts, called waves, 2-3 times in a menstrual cycle. It is unknown whether these waves of follicle growth also occur in women with amenorrhea or if there is abnormal/absent follicle growth. Further, oligo- or amenorrhea …

regular menstrual cycles
pelvic examination
insulin resistance
  • 26 Jan, 2021
  • 1 location
Cutaneous Denervation in Alcoholic Neuropathy

Peripheral neuropathy is a frequent neurological complication of chronic alcoholism. Most studies evaluated large-fiber involvement by nerve conduction studies (NCS). Since previous studies document the predominant injury of small myelinated and unmyelinated fibers in patients with alcoholic neuropathy, it will be imperative to know their prevalence and clinical significance. Moreover, …

skin biopsy
protein gene product
peripheral nerve disease
nerve conduction studies
  • 07 Nov, 2020
  • 1 location
Comorbidities and Coinfections in Latent TB

Approximately 2 billion people worldwide are infected with Mycobacterium tuberculosis (TB), with 90% of individuals having latent infection (LTBI). The control of TB requires clearly delineated helper T cell (Th) 1 responses and, to a lesser extent, Th17 responses, which both play important roles in the induction and maintenance of …

hemoglobin a1c
  • 27 Jun, 2021
  • 1 location