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Found 14 clinical trials
A Program to Increase Sickle Cell Trait Knowledge Among Parent of Young Children Identified in Newborn Screening

This is a study for parents of young children with Sickle Cell Trait (SCT) identified by newborn screening who are referred and present for in person SCT education at the Institution. The study will determine the feasibility of implementing a SCT education program (SCTaware) that is appropriate for all parents, …

  • 2 views
  • 01 Feb, 2021
  • 1 location
Sleep Apnea in Sickle Cell Disease

with OSA could trigger hemoglobin S polymerization and red blood cell (RBC) sickling, leading to further blood rheological alterations, hence increasing the risks for VOC. Moreover, OSA has been

sickle cell trait
sickle hemoglobin
vaso-occlusive crisis
blood transfusion
hemoglobin s
  • 10 views
  • 28 Jan, 2021
  • 5 locations
Precision Exercise in Children With Malignant Hemopathies

In the early years of life and during adolescence, physical activity is crucial for good development of motor skills. It is even more so for those children and young people who are forced to undergo anti-cancer therapies and therefore undergo long periods of hospitalization (often bedridden) and prolonged periods of …

  • 0 views
  • 23 Jan, 2021
Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects With Stable Sickle Cell Disease

Background Sickle cell disease (SCD) is an inherited hemoglobin disorder. People with SCD have an increased chance for getting blood clots. Researchers want to see if a dietary supplement called Isoquercetin can decrease levels of inflammation and blood clotting in people with SCD. Objective To see how Isoquercetin works in …

thalassemia
hydroxyurea
vaso-occlusive crisis
blood transfusion
electrophoresis
  • 0 views
  • 02 Aug, 2021
  • 1 location
Peripheral Blood Stem Cell Collection From Patients With Sickle Cell Disease (SCD) Using Plerixafor

With recent advances in gene editing, gene therapy is becoming a viable curative treatment option for sickle cell disease. In order to do genetic manipulation, investigators need to collect hematopoietic stem cells from patients with sickle cell disease. In this study, investigators want to study the safety and feasibility of …

plerixafor
apheresis
hydroxyurea
conjugated bilirubin
blood transfusion
  • 0 views
  • 02 Aug, 2021
  • 1 location
Safety Tolerability Pharmacokinetics and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat

Background Sickle cell disease (SCD) is a disorder that causes episodes of acute pain and progressive organ damage. Ways to manage SCD have evolved slowly. Treatments do not always work. Researchers want to see if a drug called mitapivat can help people with SCD. Objective To test the long-term tolerability …

  • 0 views
  • 18 Mar, 2021
  • 1 location
DREPAMASSE Study - Evaluation of a Newborn Screening for Sickle Cell Disease by Tandem Mass Spectrometry

Three methods are actually used in newborn screening for sickle cell disease (SCD) in France: isoelectric focusing, high performance liquid chromatography and capillary electrophoresis. New technologies are currently under development such as Matrix Assisted Laser Desorption Ionisation - Time of Flight (MALDI-TOF) and tandem mass spectrometry (MS/MS) using the SpOtOn …

  • 0 views
  • 29 Mar, 2021
  • 3 locations
Collection and Storage of Umbilical Cord Stem Cells for Treatment of Sickle Cell Disease

This study will determine the best ways to collect, process and store umbilical cord blood from babies with sickle cell disease, sickle cell trait and unaffected babies. Sickle cell disease is an abnormality of the hemoglobin in red blood cells that causes the cells to change shape and clump together, …

anemia
hemoglobin s
cell transplantation
thalassemia
sickle cell trait
  • 41 views
  • 10 Jul, 2021
  • 1 location
At-Home Research Study for Patients With Autoimmune Inflammatory Genetic Hematological Infectious Neurological CNS Oncological Respiratory Metabolic Conditions

We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research. We make it easy for patients to contribute to research for medical conditions that matter most to them, regardless of their location or ability to travel.

  • 88 views
  • 23 Jan, 2021
  • 1 location
Links Between Cognitive Functions and Clinical Biological and Neuroradiological Outcomes in Adults With Sickle Cell Disease.

Sickle cell disease (SCD) is an inherited blood disorder. Symptoms include acute and chronic complications. Due to progress in SCD care, patients with SCD are living longer than before and we focus more attention in chronic complications. Children with SCD experience worse cognitive functions than healthy children, and fewer is …

anemia
blood disorder
transcranial doppler ultrasonography
vaso-occlusive crisis
chest syndrome
  • 0 views
  • 26 Jan, 2021
  • 1 location