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Found 17 clinical trials
CHOICES3: Sickle Cell Disease Parenting CHOICES (CHOICES3)

The study will use web-based data collection (SCKnowIQ) and intervention delivery strategies enhanced by nudges and tailored boosters in a sample of 430 adult men and women, aged 18-35 yr with SCD or SCT, at-risk, and planning within 2 years to have a child free of SCD.

electrophoresis
thalassemia
  • 0 views
  • 13 Jun, 2022
  • 1 location
Effect of Exercise on Biomarkers in SCT

This study measures the effect of exercise on a variety of biomarkers in blood and urine selected to evaluate the physiological pathways of hemolysis, myolysis, thrombosis, inflammation, and renal function in subjects with sickle cell trait. These pathways have been shown to be associated with adverse events in athletes and …

Accepts healthy volunteers
hemolysis
sickle cell trait
  • 0 views
  • 22 Mar, 2022
  • 1 location
A Program to Increase Sickle Cell Trait Knowledge Among Parent of Young Children Identified in Newborn Screening (SCTaware)

This is a study for parents of young children with Sickle Cell Trait (SCT) identified by newborn screening who are referred and present for in person SCT education at the Institution. The study will determine the feasibility of implementing a SCT education program (SCTaware) that is appropriate for all parents, …

Accepts healthy volunteers
sickle hemoglobin
hemoglobin s
sickle cell trait
  • 2 views
  • 15 May, 2022
  • 1 location
Sleep Apnea in Sickle Cell Disease (DREPAPNEE)

with OSA could trigger hemoglobin S polymerization and red blood cell (RBC) sickling, leading to further blood rheological alterations, hence increasing the risks for VOC. Moreover, OSA has been

blood transfusion
sickle hemoglobin
hemoglobin s
vaso-occlusive crisis
sickle cell trait
  • 10 views
  • 01 Feb, 2022
  • 3 locations
Peripheral Blood Stem Cell Collection From Patients With Sickle Cell Disease (SCD) Using Plerixafor

With recent advances in gene editing, gene therapy is becoming a viable curative treatment option for sickle cell disease. In order to do genetic manipulation, investigators need to collect hematopoietic stem cells from patients with sickle cell disease. In this study, investigators want to study the safety and feasibility of …

conjugated bilirubin
blood transfusion
plerixafor
apheresis
hydroxyurea
  • 0 views
  • 09 Aug, 2022
  • 1 location
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat

Background Sickle cell disease (SCD) is a disorder that causes episodes of acute pain and progressive organ damage. Ways to manage SCD have evolved slowly. Treatments do not always work. Researchers want to see if a drug called mitapivat can help people with SCD. Objective To test the long-term tolerability …

absolute neutrophil count
blood transfusion
acute pain
a hemoglobin
platelet count
  • 0 views
  • 27 Jul, 2022
  • 1 location
Interest of Famotidine in Children With Sickle Cell Disease (FAMODREP)

The purpose of this study is to determine whether oral famotidine, a histamine type 2 receptor antagonist already widely used with very few side effects in other indications in children, is effective in reducing endothelial expression of P-selectin in children with sickle cell disease (SCD). This pilot study will constitute …

vaso-occlusive crisis
voxelotor
priapism
chest syndrome
splenic sequestration
  • 0 views
  • 15 Mar, 2022
A Trial to Assess Haploidentical T-depleted Stem Cell Transplantation in Patients With SCD

HSCT is currently the only curative option for SCD but less than 20% of SCD patients have a MD donor available. So far, all curative approaches beyond a MSD HSCT at young age are non-satisfactory. With the lack of a suitable donor for the vast majority of patients, the major …

sickle hemoglobin
hemoglobin s
priapism
osteonecrosis
chest syndrome
  • 0 views
  • 29 May, 2022
  • 4 locations
Low Dose Iron Chelation as TReatment of Oxidative Damage in Sickle Cell Disease (TROS)

Objective To study the safety and efficacy of deferasirox as treatment of oxidative stress in adult subjects with sickle cell disease. Endpoints The investigators will determine whether treatment with iron chelators results in decreased sickling of RBCs, oxidative stress, neutrophil activation, inflammation, endothelial activation and hypercoagulability and ultimately reduced disease …

thal
thalassemia
iron
  • 0 views
  • 05 Jun, 2022
Collection and Storage of Umbilical Cord Stem Cells for Treatment of Sickle Cell Disease

This study will determine the best ways to collect, process and store umbilical cord blood from babies with sickle cell disease, sickle cell trait and unaffected babies. Sickle cell disease is an abnormality of the hemoglobin in red blood cells that causes the cells to change shape and clump together, …

blood test
sickle hemoglobin
hemoglobin s
cell transplantation
anemia
  • 41 views
  • 26 Jul, 2022
  • 1 location