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Found 852 clinical trials
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Eltrombopag Added to Standard Immunosuppression in Treatment-Naive Severe Aplastic Anemia

Background: Severe aplastic anemia is a rare and serious blood disorder. It happens when the immune system starts to attack the bone marrow cells. This causes the bone marrow to stop making red blood cells, platelets, and white blood cells. Standard treatment for this disease is horse-ATG and cyclosporine, which …

anemia studies
myelodysplastic syndromes
myelodysplastic syndrome (mds)
aplastic anemia
anemia
  • 172 views
  • 22 Dec, 2020
  • 1 location
Study of Ravulizumab in Pediatric Participants With HSCT-TMA

of age, with HSCT-TMA. The treatment period is 26 weeks, followed by a 26-week off-treatment follow-up period.

  • 8 views
  • 23 May, 2022
  • 51 locations
A Study to Compare T-Guard vs Ruxolitinib for Treatment of Steroid-Refractory Acute Graft-vs-Host Disease (BMT CTN 2002) (2002)

This is an open-label, randomized, Phase 3, multicenter trial, which has been designed to compare the efficacy and safety of T-Guard to ruxolitinib in patients with Grade III or IV Steroid-Refractory acute Graft-Versus-Host Disease (SR-aGVHD). The primary hypothesis is that T-Guard treatment will improve the Day 28 complete response (CR) …

  • 0 views
  • 27 Jun, 2022
  • 5 locations
Azole-echinocandin Combination Therapy for Invasive Aspergillosis

The goals of this study are 3-fold: First, the main study and the primary endpoint will evaluate if the overall mortality can be decreased with initial azole-echinocandin combination therapy compared with triazole monotherapy in patients with IA and documented voriconazole susceptibility. Second, the study design described will also allow to …

  • 0 views
  • 16 Oct, 2021
  • 4 locations
Remote Ischemic Conditioning in HSCT

determine tolerability and safety of remote ischemic conditioning in pediatric and adolescent patients undergoing HSCT, with the goal of a larger trial of efficacy to follow. The secondary purpose is to

  • 0 views
  • 17 Sep, 2021
  • 1 location
Adult B-ALL Treated by CART Cell Bridging Allogeneic Hematopoietic Stem Cell Transplantation

/R) adult acute lymphoblastic leukemia bridging allogeneic hematopoietic stem cell transplantation.

  • 0 views
  • 26 Jan, 2021
  • 1 location
Individualized Dose Study of ATG in Haploidentical Hematopoietic Stem Cell Transplantation

haploidentical peripheral blood stem cell transplantation (haplo-PBSCT).

  • 0 views
  • 24 Mar, 2022
  • 1 location
Individualized Dose Study of ATG in Haploidentical Hematopoietic Stem Cell Transplantation

haploidentical peripheral blood stem cell transplantation (haplo-PBSCT).

  • 0 views
  • 04 Jun, 2022
  • 1 location
  • 0 views
  • 03 May, 2022
  • 5 locations
Flotetuzumab for Relapsed Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Following Allogeneic Hematopoietic Cell Transplantation (Allo-HCT)

The investigators hypothesize that flotetuzumab for relapsed AML following allo-HCT will be safe, tolerable and may facilitate preferential immune effector cell retargeting of leukemic cells

  • 0 views
  • 26 Apr, 2022
  • 1 location