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Found 520 clinical trials
Pneumonia in the ImmunoCompromised - Use of the Karius Test for the Detection of Undiagnosed Pathogens

Given the need for a more sensitive pathogen detection test in patients with immunocompromised pneumonia, this study will evaluate the performance of the Karius Test, a novel NGS blood test for the diagnosis of infectious diseases. We will compare the performance of the Karius Test to the results of microbiologic …

hematologic malignancies
blood test
multiple myeloma (mm)
  • 26 Jan, 2021
  • 7 locations
The Influence of CYP2C19 Polymorphisms on the Safety and Efficacy of Voriconazole

Voriconazole is a drug used to treat invasive fungal infections. The amount of voriconazole in a person's blood helps to determine how effectively it treats an infection, and how safe it is. Patients respond differently when receiving the same dose - some clearly benefit, other patients experience side effects, and …

  • 26 Jan, 2021
  • 1 location
Investigation of the B- and T-cell Repertoire and Immune Response in Patients With Acute and Resolved COVID-19 Infection

Background People who get infected with COVID-19 have an unpredictable risk to worsen and die. This makes it hard to decide who can quarantine at home and who should be treated at a hospital. Researchers think the risk may be related to how a person s B and T cells …

  • 28 Jul, 2021
  • 5 locations
Collection of Peripheral Blood Mononuclear Cells (PBMCs) From Healthy People for the Expansion of T Cells for Adoptive Cell Therapy

Title: Collection of Peripheral Blood Mononuclear Cells (PBMCs) from Healthy People for the Expansion of T Cells for Adoptive Cell Therapy Background New therapies are being developed that use a person s own immune system to fight tumors. Some of the tumors being studied include cancers caused by viruses. Researchers …

systolic blood pressure
diastolic blood pressure
hepatitis b
  • 19 Mar, 2021
  • 1 location
Pharmacokinetics of Venetoclax in Patients With Acute Myeloid Leukemia

Venetoclax is a treatment for chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). However, the pharmacokinetic data in Chinese population, as well as the change of venetoclax plasma concentration while taking CYP enzyme inducers or inhibitors, remained unknown so far. Therefore, the aim of this study is to investigate …

  • 26 Jan, 2021
  • 1 location
TRACERx Renal CAPTURE Sub-study

TRACERx Renal: This is a translational study, which, aims to develop prognostic and predictive biomarkers for patients with renal cell carcinoma (RCC). CAPTURE Sub-study: Covid-19 antiviral response in a pan-tumour immune monitoring study

primary cancer
cancer diagnosis
  • 24 Jan, 2021
  • 4 locations
Acquisition of Blood and Tumor Tissue Samples From Patients With Gastrointestinal Cancer

Background Gastrointestinal cancers can occur in the throat, stomach, gallbladder, liver, pancreas, and colon. Researchers are interested in evaluating how active the immune system is in trying to fight the cancer by studying blood and tumor tissue donated from individuals who have been diagnosed with gastrointestinal cancers. Objectives To collect …

treatment regimen
colon cancer
  • 30 Apr, 2021
  • 1 location
Metabolic Syndrome in Childhood Cancer Survivors

The research is devoted to studying the features of the metabolic syndrome in cancer survivors in childhood is supposed to answer the following questions: How can metabolic syndrome be diagnosed in the Russian population of survivors of acute lymphoblastic leukemia and non-Hodgkin's lymphomas? What are the features of the clinical …

  • 22 Jan, 2021
  • 1 location
Platelets Function and Cardiovascular Events in Patients With End Stage Renal Disease

The purpose of this study is to perform a prospective evaluation regarding the relationship between platelets function and cardiovascular events in patients with ESRD. The study will include 100-200 patients with ESRD, age 18 years or older, treated in the nephrology division of Assaf Harofeh medical center. The primary end …

coronary disease
  • 07 Nov, 2020
  • 1 location
Ocular Surface Disease in Chronic Graft-Versus-Host Disease (GVHD) Patients

This study aims to profile the ocular surface inflammation of chronic Graft-Versus-Host Disease patients by investigating conjunctival cells, and clinical imaging for conjunctival redness and tear stability. Hence, the investigators expect to find an increased in inflammatory cell population in GVHD conjunctival samples.

chronic graft versus host disease
graft versus host disease
ocular surface disease
  • 28 Mar, 2021
  • 1 location