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Found 598 clinical trials
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Effects of Carvedilol on Cardiotoxicity in Cancer Patients Submitted to Anthracycline Therapy

failure) are related to the use of anthracyclines. Anthracyclines are part of the chemotherapy regimen for solid tumors and hematological neoplasms in children and adults, and are associated with an

primary cancer
treatment regimen
anthracyclines
  • 0 views
  • 08 Oct, 2021
  • 1 location
None
Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Lemzoparlimab (TJ011133) With or Without Oral/IV Dexamethasone and in Combination With Oral/IV/Subcutaneous Anti-Myeloma Regimens in Adult Participants With Multiple Myeloma

Multiple myeloma (MM) accounts for more than 10% of all blood cancers and 1% of all cancers. The purpose of this study is to assess how safe lemzoparlimab (TJ01133) is and how lemzoparlimab

lenalidomide
measurable disease
progressive disease
dexamethasone
carfilzomib
  • 0 views
  • 17 Oct, 2021
  • 31 locations
None
Prospective Biobanking Study in Ovarian Breast and Head and Neck Cancer Patients Aiming at Better Understand the Link Between the Molecular Alterations of the Tumor Itself Its Microenvironment and Immune Response (SCANDARE)

SCANDARE is a prospective biobanking study on tumor (+/- nodes), plasma and blood samples at different time points in ovarian, triple negative breast and head and neck cancer patients. This study will allowed to identify new molecular and/or immunological biomarkers associated with clinical and biological features of the tumors. All …

immunomodulator
cancer chemotherapy
ovarian cancer
cancer of the ovary
breast cancer
  • 3 views
  • 28 Jan, 2021
  • 2 locations
None
Inpatient Palliative Care for Patients Undergoing Hematopoietic Stem Cell Transplantation

This research study is evaluating the impact of early involvement of a palliative care team working with the transplant oncology team will have on the quality of life, symptoms, and mood of patients undergoing stem cell transplantation.

cell transplantation
hematologic malignancy
  • 8 views
  • 11 Jun, 2021
  • 2 locations
None
A Study of JNJ-75276617 in Participants With Acute Leukemia

The purpose of this study is to determine the recommended Phase 2 dose(s) (RP2D[s]) of JNJ-75276617 in Part 1 (Dose Escalation) and to determine safety and tolerability at the RP2D(s) in Part 2 (Dose Expansion).

direct bilirubin
gilbert's syndrome
hydroxyurea
serum bilirubin level
acute leukemia
  • 4 views
  • 05 Dec, 2021
  • 27 locations
None
A Study of Subcutaneous Daratumumab Regimens in Combination With Bispecific T Cell Redirection Antibodies for the Treatment of Participants With Multiple Myeloma

The purpose of this study is to identify recommended Phase 2 doses (RP2Ds) for each treatment combination (between daratumumab plus talquetamab and teclistamab plus daratumumab with or without pomalidomide) and to characterize the safety of each RP2D for selected treatment combinations.

measurable disease
immunoglobulins
daratumumab
human chorionic gonadotropin
proteasome inhibitor
  • 54 views
  • 05 Dec, 2021
  • 25 locations
None
Daratumumab Retreatment in Participants With Multiple Myeloma Who Have Been Previously Treated With Daratumumab

The purpose of this study is to compare the efficacy (rate of very good partial response [VGPR] or better as best response as defined by the International Myeloma Working Group [IMWG] criteria) of daratumumab subcutaneous (Dara-SC) in combination with carfilzomib and dexamethasone (Kd) with the efficacy of Kd in participants …

corticosteroids
dexamethasone
carfilzomib
cell transplantation
daratumumab
  • 23 views
  • 05 Dec, 2021
  • 165 locations
None
A Study of the Combination of Talquetamab and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

The purpose of this study is to identify the recommended Phase 2 regimen(s) (RP2R[s]) and schedule for the study treatment (Part 1) and to characterize the safety of the RP2R(s) for the study treatment (Part 2). The RP2R(s) will describe the combination doses and schedules of (tal+tec+dara) the treatment combinations …

lenalidomide
human chorionic gonadotropin
refractory multiple myeloma
bortezomib
carfilzomib
  • 0 views
  • 12 Nov, 2021
  • 14 locations
None
Study on Tailored Treatment in Elderly Patients With Newly Diagnosed Primary Lymphoma of Central Nervous System

Primary central nervous system lymphomas are rare aggressive malignancies, usually treated in two steps: an induction phase (where a combination of chemotherapy is given) followed by a consolidation phase (where patients usually receive one of the following: whole-brain irradiation, chemotherapy supported by autologous stem-cell transplantation, other type of chemotherapy, or …

lenalidomide
maintenance treatment
nervous
whole-brain radiotherapy
methotrexate
  • 0 views
  • 05 Dec, 2021
  • 42 locations
None
A Study of CC-95251 a Monoclonal Antibody Directed Against SIRP in Subjects With Advanced Solid and Hematologic Cancers

Study CC-95251-ST-001 is an open-label, Phase 1, dose escalation (Part A) and expansion (Parts B and C), first-in-human clinical study of CC-95251 in subjects with advanced cancers.

solid neoplasm
measurable disease
monoclonal antibodies
cetuximab
conventional treatment
  • 63 views
  • 31 Oct, 2021
  • 42 locations