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Found 15 clinical trials
Efficacy and Safety of Rapamycin to Complex Vascular Anomalies in Pediatric Patients

KHE and TA are rare tumors and some of the cases may lead to life-threatening complications including Kasabach-Merritt Phenomenon. Typically treated with steroids and vincristine, a majority of the cases do not have good prognosis. Complex vascular malformations are always managed by surgery,sclerotherapy and embolization therapy. While many of the …

  • 0 views
  • 18 Nov, 2021
  • 1 location
Efficacy and Safety of Different Concentrations of Sirolimus in the Treatment of Kaposiform Hemangioendothelioma.

The purpose of this study is to compare the efficacy and safety of different concentration gradients of sirolimus in the treatment of Kaposiform hemangioendothelioma.

  • 0 views
  • 05 May, 2022
  • 1 location
Different Doses of Sirolimus for the Maintenance Treatment of Kaposiform Hemangioendothelioma

The purpose of this study is to compare the efficacy and safety of different doses of sirolimus in the maintenance treatment of kaposiform hemangioendothelioma.

hemangioendotheliomas
  • 0 views
  • 11 May, 2022
  • 1 location
Prospective Identification of Predictive Biomarkers of Trabectedin Efficacy in Non-L Soft-tissue Sarcoma Patients (PIPER)

This is a biology driven, monocentric study, designed to identify biomarkers of activity of trabectedin in patients with advanced non-L soft-tissue sarcoma. The aim of this study is to implement high-throughput profiling technologies to identify predictive biomarkers of trabectedin efficacy through sequential tumor biopsies and blood sample collection in sarcoma …

measurable disease
trabectedin
metastases
liposarcoma
leiomyosarcoma
  • 0 views
  • 22 Mar, 2022
  • 1 location
Tacrolimus for the Treatment of Superficial Kaposiform Hemangioendothelioma and Tufted Angioma

The aim of this study was to evaluate the efficacy and safety of topical application of tacrolimus for superficial Kaposiform hemangioendothelioma (KHE) and tufted angioma (TA).

  • 0 views
  • 22 Mar, 2022
  • 1 location
Safety and Efficacy of Low-dose Sirolimus to Kaposiform Hemangioendothelioma

to evaluate the safety and efficacy of Low-dose sirolimus in Kaposiform Hemangioendothelioma in Chinese children by a prospective, randomized open trial.

hemangioendotheliomas
kasabach-merritt phenomenon
  • 0 views
  • 09 Aug, 2022
  • 1 location
Eribulin in Angiosarcoma and Epithelioid Hemangioendothelioma (EHE)

This research study is studying a drug as a possible treatment for Angiosarcoma or Epithelioid hemangioendothelioma (EHE). -The drug involved in this study is Eribulin

ct scan
measurable disease
tumor cells
cancer
angiosarcoma
  • 122 views
  • 25 Mar, 2022
Guided Discontinuation Versus Maintenance Treatment of Sirolimus in Pediatric Patients With Kaposiform Hemangioendothelioma

This randomized controlled trial aims to compare guided discontinuation with maintenance treatment of sirolimus in pediatric patients with KHE.

  • 0 views
  • 16 Aug, 2021
  • 1 location
Percutaneous Administration of Sirolimus in the Treatment of Superficial Complicated Vascular Anomalies

In this study, we investigate the safety and efficacy of topical sirolimus in the treatment of superficial complicated vascular anomolies.

  • 0 views
  • 21 Mar, 2022
  • 1 location
Oral TEAD Inhibitor Targeting the Hippo Pathway in Subjects With Advanced Solid Tumors

This is a Phase 1, first-in-human (FIH) clinical study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antitumor activity of IK-930, an oral TEAD inhibitor, administered orally (PO) as monotherapy in subjects with advanced solid tumors with or without gene alterations in the Hippo pathway for whom …

cancer
formalin-fixed paraffin-embedded
thymoma
  • 0 views
  • 20 Jun, 2022
  • 4 locations