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Found 46 clinical trials
Title: Effect of Opioid Receptor Modulation on Alcohol Self-Administration and Neural Response to Alcohol Cues in Heavy Drinkers: Role of OPRM1 Gene Variation

Background Drugs like nalmefene interfere with opioid receptors. This might reduce drinking. The gene OPRM1 determines opioid receptor functions. Researchers want to see if nalmefene affects people s responses to alcohol cues. They also want to compare how nalmefene affects people with different forms of OPRM1. Objectives To test nalmefene …

Accepts healthy volunteers
  • 9 views
  • 27 Jun, 2022
  • 1 location
Pioglitazone for the Treatment of Alcohol Use Disorder (PAUSE)

Alcohol Use Disorder (AUD) is common among Veterans but medication treatment is used infrequently and the impact of these treatments are small to moderate at best. Pioglitazone, a medication FDA approved for diabetes, has been shown in pre-clinical studies to reduce alcohol. The proposed study will test the efficacy of …

antidepressants
scid
diabetes
heavy drinking
  • 29 views
  • 01 May, 2022
  • 2 locations
Mobile Mindfulness for Alcohol Use and PTSD Among Veterans

The purpose of the present study is to develop and test a mobile mindfulness intervention for Alcohol Use Disorder and PTSD among OEF/OIF veterans

Accepts healthy volunteers
  • 0 views
  • 12 May, 2022
  • 1 location
Virtual Reality-Assisted Cognitive Behavioral Therapy for Alcohol Dependence (CRAVR)

The study is a single-blinded, randomized, controlled, 12 months clinical trial. The objective is to investigate the feasibility, effects and side-effects of virtual reality-assisted cognitive behavioral therapy (VR-CBT) vs. cognitive behavioral therapy (CBT) in patients with a diagnosis of alcohol dependence.

  • 0 views
  • 21 Nov, 2021
  • 1 location
AAT-App Outpatient Trial (AAT-App)

Cognitive biases contribute to the difficulty experienced by heavy drinkers wishing to reduce their alcohol use. Recent interventions designed to reduce cognitive biases demonstrate efficacy for Approach Bias Modification (ApBM). Reductions in the likelihood of relapse have been found after ApBM in Alcohol Use Disorder (AUD) patients during residential treatment. …

  • 0 views
  • 30 May, 2022
  • 1 location
Comparison of ALD NASH and Healthy Control Patients

The availability of biological samples from individuals with alcoholic liver disease (ALD), as well as samples from appropriate heavy drinking, yet healthy controls and non-drinking healthy

liver disease
alcohol use disorder
fibrosis
noac
cirrhosis
  • 22 views
  • 18 Sep, 2021
  • 1 location