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Found 44 clinical trials
PROGRESSive Withdrawal Esomeprazole and Acid-related Symptoms (PROGRESS)

could theoretically lead to acid-related symptoms such as heartburn, acid regurgitation, or dyspepsia that might result in resumption of therapy. A plausible physiologic theory for the rebound

esomeprazole 40 mg
rebound phenomenon
gastrointestinal symptoms
proton pump inhibitors
  • 25 Mar, 2022
  • 2 locations
Anterior Gastropexy vs. No Anterior Gastropexy for Paraesophageal Hernia Repair

This study evaluates the effect of anterior gastropexy (one or more sutures fixing the stomach to the inner abdominal wall) on improving durability of paraesophageal hernia repair. Half of participants will receive anterior gastropexy, while the other half will not. The hypothesis is that anterior gastropexy will help to prevent …

  • 25 Mar, 2022
  • 1 location
Effects of Intraoperative Vagal Block on Reducing the Postoperative Cough After Thoracic Surgery

Randomized controlled study to investigate the role of intraoperative vagal nerve block for preventing the postoperative cough in patients who received the pulmonary resection for lung cancer

  • 29 Jan, 2021
  • 1 location
Individualized Diagnosis and Treatment of Extraesophageal Reflux in Patients With Chronic Cough

Chronic cough is a very unpleasant symptom, significantly reduces the patient's quality of life, and bothers the neighborhood. A very common cause or co-factor of chronic cough is extraesophageal reflux (EER). The aim of the project is the precise diagnosis of EER in patients with chronic cough (in patients with …

  • 06 Aug, 2021
  • 1 location
Esophagogastric Junction Distensibility During Hiatal Hernia Repair

The investigators aim to ascertain the effects of hiatal hernia repair and fundoplication on the distensibility of the esophagogastric junction (EGJ) as measured by FLIP topography/impedance planimetry. The investigators also aim to assess for any correlation between values of EGJ distensibility and GERD related quality of life (QOL) and dysphagia …

  • 07 Oct, 2022
  • 1 location
Modulate Cellular Stress in the Immune Cells to Reduce Rate of Symptomatic Viral Infection

To determine the efficacy of metformin in reducing the rate of symptomatic YF17D infection, and to elucidate the effects of metformin on YF17D viremia and the downstream adaptive immune response, we hereby propose a randomised, double-blind, placebo-controlled clinical trial that is coupled with a system biology approach. We plan to …

Accepts healthy volunteers
body mass index
  • 26 May, 2022
  • 1 location
Is in Vitro Maturation of Oocytes Influenced by the Origin of Gonadotropins Used in Maturation Medium: is There a Difference in Efficiency When Using Urinary Versus Recombinant Produced Follicle Stimulating Hormone and Human Chorionic Gonadotropin (IVM-FSHhCG)

Standard IVM currently contains urinary purified hormones which might contain contaminants possibly affecting maturation of embryo development. The investigators will test if the efficiency in terms of oocyte maturation after IVM of recombinant (without contaminants) is equivalent to urinary gonadotropins. Urinary and recombinant FSH and hCG will be used in …

  • 25 May, 2022
  • 1 location
Blood And Clot Thrombectomy Registry And Collaboration (BACTRAC)

This is a prospective open enrollment registry to evaluate arterial blood and thrombus removed during the standard thrombectomy procedure, which will then be used for the purposes of identifying biological markers, inflammatory cell infiltrates, and biological states in large vessel occlusive stroke in the human condition. The primary objectives are …

  • 19 Jun, 2022
  • 1 location
Peroral Endoscopic Myotomy (POEM) for the Treatment of Achalasia (POEM)

preferences and local expertise. Surgical myotomy provides long lasting improvement in dysphagia but even when done laparoscopically is invasive and complex. Extensive acid reflux resulting in significant

balloon dilatation
peroral endoscopic myotomy
chest pain
chronic disease
  • 03 Jun, 2022
  • 1 location
The WATS3D (Wide Area Transepithelial Sample Biopsy With 3-Dimensional Computer-Assisted Analysis) U.S. Registry

, or both can predict which patients with heartburn develop Barrett's esophagus, (an abnormality in the esophagus that may lead to cancer), and which patients with Barrett's esophagus develop precancer

radiofrequency ablation
  • 04 Oct, 2022
  • 1 location