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Found 351 clinical trials
Early Feasibility Study of the PLAR Implant and Delivery System to Treat Functional Mitral Regurgitation ( EXPLORE FMR ) (EXPLORE FMR)

An early feasibility study to evaluate the safety and feasibility of the PLAR Implant and Delivery System to treat severe functional mitral regurgitation and to gather preliminary data on its performance thereby providing guidance for future clinical development. The study is a single-arm registry with the last follow-up visit at …

  • 23 Mar, 2022
Angiotensin II as a First-line Vasopressor for Distributive Shock During or After Heart Transplantation or Durable Left Ventricular Assist Device Implantation: A Pilot Study

This is a single-center, randomized, double-blind, placebo-controlled pilot study. A total of 40 patients who develop distributive shock, intra-operatively or post-operatively within 48 hours of heart transplant or left ventricular assist device placement will be enrolled. Participants will be randomized to Angiotensin II (Giapreza) vs. placebo plus standard of care, …

  • 21 Oct, 2022
  • 1 location
Enhancement of the Haemostatic Effect of Platelets in the Presence of High Normal Concentrations of Von Willebrand Factor (Will-Plate)

Assessment of high-normal dosage of Wilate ® compared to placebo administered in combination with platelets to assess reduction of amount of blood loss, need of transfusion products and outcome (length of stay, mortality) in patients with bleeding in comparison.

coagulation factor
  • 07 Oct, 2022
  • 1 location
Wheat Beer for Prevention of Delirium in Intensive Care Patients (BABE-D)

The investigators hypothesise that the daily administration of 0.5L alcohol-containing wheat beer at 8 pm over a study period of 6 days in a row leads to a lower prevalence of delirium compared to water following the same administration scheme.

  • 19 Aug, 2023
  • 1 location
Evaluating of Role of Myeloperoxidase in Prediction of Outcomes of Cardiac Surgery Procedures.

The main objection is to investigate molecular biology of myocardial damage during cardiac surgery procedures.

heart disease
bypass graft
heart surgery
  • 22 Nov, 2021
  • 1 location
Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery (TRICS-IV)

younger undergoing cardiac surgery on cardiopulmonary bypass, using a superiority trial design.

cardiopulmonary bypass
  • 12 Mar, 2022
  • 6 locations
Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients (CODEX)

, many patients have persistent memory impairment for weeks to months after surgery. Cardiac surgery appears to carry the highest risk of postoperative cognitive dysfunction (POCD). These cognitive

cognitive impairment
postoperative cognitive dysfunction
cardiac surgery
coronary artery bypass graft
  • 28 Feb, 2022
  • 1 location
Acute Normovolemic Hemodilution in High Risk Cardiac Surgery Patients. (ANH)

Transfusions are one of the most overused treatments in modern medicine, and saving blood is one important issue all around the world. Cardiac surgery makes up a large percentage of the overall

  • 09 Jul, 2022
  • 12 locations
Multisite Tissue Oxygenation Guided Perioperative Care in Cardiac Surgery

The BOTTOMLINE-CS trial is an international, open, single-center, pragmatic, randomised controlled trial to investigate whether multisite tissue oxygen saturation monitoring-guided perioperative care reduces composite complications within 30 days of randomization in off-pump coronary artery bypass grafting.

  • 13 Nov, 2021
  • 1 location
  • 23 Feb, 2022
  • 1 location